Details of the Drug

General Information of Drug (ID: DMRV7H0)

Drug Name

Bumetanide

Synonyms

Aquazone; Bumedyl; Bumetanida; Bumetanidum; Bumethanide; Bumex; Burine; Burinex; Butinat; Cambiex; Diurama; Drenural; Fontego; Fordiuran; Lixil; Lunetoron; Miccil; Segurex; Yurinex; AstraZeneca Brand of Bumetanide; Atlantis Brand of Bumetanide; Bumetanide AstraZeneca Brand; Bumetanide Atlantis Brand; Bumetanide Farmacusi Brand; Bumetanide Grossmann Brand; Bumetanide Leo Brand; Bumetanide Roche Brand; Bumetanide Senosiain Brand; Farmacusi Brand of Bumetanide; Grossmann Brand of Bumetanide; Leo Brand of Bumetanide; Roche Brand of Bumetanide; Senosiain Brand of Bumetanide; B 3023; PF 1593; PF1593; Bumetanida [INN-Spanish]; Bumetanidum [INN-Latin]; Bumex (TN); Bumex, Bumetanide; Lixil-Leo; PF-1593; Ro 10-6338; Bumetanide (JP15/USP); Ro-10-6338; Bumetanide (JP15/USP/INN); Bumetanide [USAN:BAN:INN:JAN]; 3-(Aminosulfonyl)-5-(butylamino)-4-phenoxybenzoic acid; 3-(Butylamino)-4-phenoxy-5-sulfamoylbenzoic acid; 3-(aminosulfonyl)-5-(butylamino)-4-(phenyloxy)benzoic acid; 3-butylamino-4-(phenoxy)-5-sulfamoylbenzoic acid

Indication

Disease Entry	ICD 11	Status	REF
Congestive heart failure	BD10	Approved	[1]
Edema	MG29	Approved	[2]
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Therapeutic Class

Diuretics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

#Ro5 Violations (Lipinski): 0

Molecular Weight (mw)

364.4

Logarithm of the Partition Coefficient (xlogp)

2.8

Rotatable Bond Count (rotbonds)

Hydrogen Bond Donor Count (hbonddonor)

Hydrogen Bond Acceptor Count (hbondacc)

ADMET Property

BDDCS Class: Biopharmaceutics Drug Disposition Classification System (BDDCS) Class 3: high solubility and low permeability [3]
Bioavailability: 90% of drug becomes completely available to its intended biological destination(s) [4]
Clearance: The drug present in the plasma can be removed from the body at the rate of 2.5 mL/min/kg [5]
Elimination: 45% of drug is excreted from urine in the unchanged form [3]
Half-life: The concentration or amount of drug in body reduced by one-half in 60 - 90 minutes [5]
Metabolism: The drug is metabolized via oxidation of the N-butyl side chain []
MRTD: The Maximum Recommended Therapeutic Dose (MRTD) of drug that ensured maximising efficacy and moderate side effect is 0.45826 micromolar/kg/day [6]
Unbound Fraction: The unbound fraction of drug in plasma is 0.031% [5]
Vd: Fluid volume that would be required to contain the amount of drug present in the body at the same concentration as in the plasma 0.16 L/kg [5]
Water Solubility: The ability of drug to dissolve in water is measured as 0.1 mg/mL [3]

Chemical Identifiers

Formula: C17H20N2O5S
IUPAC Name: 3-(butylamino)-4-phenoxy-5-sulfamoylbenzoic acid
Canonical SMILES: CCCCNC1=C(C(=CC(=C1)C(=O)O)S(=O)(=O)N)OC2=CC=CC=C2
InChI: InChI=1S/C17H20N2O5S/c1-2-3-9-19-14-10-12(17(20)21)11-15(25(18,22)23)16(14)24-13-7-5-4-6-8-13/h4-8,10-11,19H,2-3,9H2,1H3,(H,20,21)(H2,18,22,23)
InChIKey: MAEIEVLCKWDQJH-UHFFFAOYSA-N

Cross-matching ID

PubChem CID: 2471
ChEBI ID: CHEBI:3213
CAS Number: 28395-03-1
DrugBank ID: DB00887
TTD ID: D0R7HO
VARIDT ID: DR00272
ACDINA ID: D00081

Combinatorial Drugs (CBD)

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Repurposed Drugs (RPD)

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Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Solute carrier family 12 member 1 (SLC12A1)	TTS087L	S12A1_HUMAN	Blocker	[7]

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Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Thiazide-sensitive sodium-chloride cotransporter (SLC12A3)	DT6MDC9	S12A3_HUMAN	Substrate	[8]
Monocarboxylate transporter 6 (SLC16A5)	DT3I124	MOT6_HUMAN	Substrate	[9]
Organic anion transporter 2 (SLC22A7)	DT0OC1Q	S22A7_HUMAN	Substrate	[10]
Organic anion transporter 4 (SLC22A11)	DT06JWZ	S22AB_HUMAN	Substrate	[11]
Organic anion transporter 3 (SLC22A8)	DTVP67E	S22A8_HUMAN	Substrate	[11]

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Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
ATP-binding cassette sub-family C member 4 (ABCC4)	OTO27PAL	MRP4_HUMAN	Regulation of Drug Effects	[12]
Cystic fibrosis transmembrane conductance regulator (CFTR)	OT6B22QH	CFTR_HUMAN	Gene/Protein Processing	[13]
HLA class I histocompatibility antigen, alpha chain G (HLA-G)	OTMLK1KN	HLAG_HUMAN	Gene/Protein Processing	[14]
Renin (REN)	OT52GZR2	RENI_HUMAN	Gene/Protein Processing	[15]
Sodium-dependent phosphate transport protein 4 (SLC17A3)	OTMJWIBM	NPT4_HUMAN	Regulation of Drug Effects	[16]
Solute carrier family 12 member 2 (SLC12A2)	OT3ZJ3LH	S12A2_HUMAN	Gene/Protein Processing	[17]
Solute carrier family 22 member 7 (SLC22A7)	OTKTNH1W	S22A7_HUMAN	Regulation of Drug Effects	[10]

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Molecular Interaction Atlas (MIA)

MIA Detail

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Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Bumetanide

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Carvedilol	DMHTEAO	Moderate	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Carvedilol.	Heart failure [BD10-BD1Z]	[18]
Digitoxin	DMWVIGP	Moderate	Increased risk of hypomagnesemia by the combination of Bumetanide and Digitoxin.	Heart failure [BD10-BD1Z]	[19]
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Coadministration of a Drug Treating the Disease Different from Bumetanide (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Cefuroxime	DMSIMD8	Moderate	Increased renal excretion of Bumetanide caused by Cefuroxime.	Acute bronchitis [CA42]	[20]
Framycetin	DMF8DNE	Major	Increased risk of nephrotoxicity by the combination of Bumetanide and Framycetin.	Alcoholic liver disease [DB94]	[21]
Cefamandole	DMNEXZF	Moderate	Increased renal excretion of Bumetanide caused by Cefamandole.	Anaerobic bacterial infection [1A00-1A09]	[20]
Dronedarone	DMA8FS5	Major	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Dronedarone.	Angina pectoris [BA40]	[22]
Cefotetan	DM07TX3	Moderate	Increased renal excretion of Bumetanide caused by Cefotetan.	Bacterial infection [1A00-1C4Z]	[20]
Ofloxacin	DM0VQN3	Minor	Decreased elimination of Bumetanide caused by Ofloxacin mediated competitive inhibition of renal tubular secretion.	Bacterial infection [1A00-1C4Z]	[23]
Kanamycin	DM2DMPO	Major	Increased risk of ototoxicity by the combination of Bumetanide and Kanamycin.	Bacterial infection [1A00-1C4Z]	[21]
Ceftizoxime	DM3VOGS	Moderate	Increased renal excretion of Bumetanide caused by Ceftizoxime.	Bacterial infection [1A00-1C4Z]	[20]
Cefoperazone	DM53PV8	Moderate	Increased renal excretion of Bumetanide caused by Cefoperazone.	Bacterial infection [1A00-1C4Z]	[20]
Cefprozil	DM7DSYP	Moderate	Increased renal excretion of Bumetanide caused by Cefprozil.	Bacterial infection [1A00-1C4Z]	[20]
Ceftriaxone	DMCEW64	Moderate	Increased renal excretion of Bumetanide caused by Ceftriaxone.	Bacterial infection [1A00-1C4Z]	[20]
Streptomycin	DME1LQN	Major	Increased risk of nephrotoxicity by the combination of Bumetanide and Streptomycin.	Bacterial infection [1A00-1C4Z]	[21]
Cefepime	DMHVWIK	Moderate	Increased renal excretion of Bumetanide caused by Cefepime.	Bacterial infection [1A00-1C4Z]	[20]
Cefpodoxime	DMJUNY5	Moderate	Increased renal excretion of Bumetanide caused by Cefpodoxime.	Bacterial infection [1A00-1C4Z]	[20]
Cefadroxil	DMMC345	Moderate	Increased renal excretion of Bumetanide caused by Cefadroxil.	Bacterial infection [1A00-1C4Z]	[20]
Rabeprazole	DMMZXIW	Moderate	Increased risk of hypomagnesemia by the combination of Bumetanide and Rabeprazole.	Bacterial infection [1A00-1C4Z]	[24]
Cefazolin	DMPDYFR	Moderate	Increased renal excretion of Bumetanide caused by Cefazolin.	Bacterial infection [1A00-1C4Z]	[20]
Netilmicin	DMRD1QK	Major	Increased risk of nephrotoxicity by the combination of Bumetanide and Netilmicin.	Bacterial infection [1A00-1C4Z]	[21]
Cefditoren	DMSUVM1	Moderate	Increased renal excretion of Bumetanide caused by Cefditoren.	Bacterial infection [1A00-1C4Z]	[20]
Cefonicid	DMTX2BH	Moderate	Increased renal excretion of Bumetanide caused by Cefonicid.	Bacterial infection [1A00-1C4Z]	[20]
Cefradine	DMUNSWV	Moderate	Increased renal excretion of Bumetanide caused by Cefradine.	Bacterial infection [1A00-1C4Z]	[20]
Cefoxitin	DMY8NC4	Moderate	Increased renal excretion of Bumetanide caused by Cefoxitin.	Bacterial infection [1A00-1C4Z]	[20]
Cariprazine	DMJYDVK	Moderate	Additive hypotensive effects by the combination of Bumetanide and Cariprazine.	Bipolar disorder [6A60]	[25]
Etidronic acid	DM1XHYJ	Moderate	Increased risk of hypocalcemia by the combination of Bumetanide and Etidronic acid.	Bone paget disease [FB85]	[26]
Ceftibuten	DMWV2AG	Moderate	Increased renal excretion of Bumetanide caused by Ceftibuten.	Bronchitis [CA20]	[20]
Ketoprofen	DMRKXPT	Moderate	Antagonize the effect of Bumetanide when combined with Ketoprofen.	Chronic pain [MG30]	[27]
Levomilnacipran	DMV26S8	Moderate	Increased risk of hyponatremia by the combination of Bumetanide and Levomilnacipran.	Chronic pain [MG30]	[28]
Sertraline	DM0FB1J	Moderate	Increased risk of hyponatremia by the combination of Bumetanide and Sertraline.	Depression [6A70-6A7Z]	[28]
Vilazodone	DM4LECQ	Moderate	Increased risk of hyponatremia by the combination of Bumetanide and Vilazodone.	Depression [6A70-6A7Z]	[28]
Selegiline	DM6034S	Moderate	Additive hypotensive effects by the combination of Bumetanide and Selegiline.	Depression [6A70-6A7Z]	[29]
Vortioxetine	DM6F1PU	Moderate	Increased risk of hyponatremia by the combination of Bumetanide and Vortioxetine.	Depression [6A70-6A7Z]	[28]
Isocarboxazid	DMAF1NB	Moderate	Additive hypotensive effects by the combination of Bumetanide and Isocarboxazid.	Depression [6A70-6A7Z]	[29]
Milnacipran	DMBFE74	Moderate	Increased risk of hyponatremia by the combination of Bumetanide and Milnacipran.	Depression [6A70-6A7Z]	[28]
Escitalopram	DMFK9HG	Moderate	Increased risk of hyponatremia by the combination of Bumetanide and Escitalopram.	Depression [6A70-6A7Z]	[28]
Desvenlafaxine	DMHD4PE	Moderate	Increased risk of hyponatremia by the combination of Bumetanide and Desvenlafaxine.	Depression [6A70-6A7Z]	[28]
OPC-34712	DMHG57U	Moderate	Additive hypotensive effects by the combination of Bumetanide and OPC-34712.	Depression [6A70-6A7Z]	[25]
Eslicarbazepine	DMZREFQ	Moderate	Increased risk of hyponatremia by the combination of Bumetanide and Eslicarbazepine.	Epilepsy/seizure [8A61-8A6Z]	[30]
Nadolol	DMW6GVL	Moderate	Increased risk of hyperglycemia by the combination of Bumetanide and Nadolol.	Essential hypertension [BA00]	[18]
Dexlansoprazole	DM1DBV5	Moderate	Increased risk of hypomagnesemia by the combination of Bumetanide and Dexlansoprazole.	Gastro-oesophageal reflux disease [DA22]	[24]
Metipranolol	DMJMVKI	Moderate	Increased risk of hypertriglyceridemia by the combination of Bumetanide and Metipranolol.	Glaucoma [9C61]	[18]
Levobetaxolol	DMSREPX	Moderate	Increased risk of hypertriglyceridemia by the combination of Bumetanide and Levobetaxolol.	Glaucoma [9C61]	[18]
Levobunolol	DMTNFCQ	Moderate	Increased risk of hypertriglyceridemia by the combination of Bumetanide and Levobunolol.	Glaucoma [9C61]	[18]
Procarbazine	DMIK367	Moderate	Additive hypotensive effects by the combination of Bumetanide and Procarbazine.	Hodgkin lymphoma [2B30]	[29]
Etelcalcetide	DMHP9BL	Major	Increased risk of hypocalcemia by the combination of Bumetanide and Etelcalcetide.	Hyper-parathyroidism [5A51]	[31]
Acebutolol	DM0TI4U	Moderate	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Acebutolol.	Hypertension [BA00-BA04]	[18]
Captopril	DM458UM	Moderate	Additive hypotensive effects by the combination of Bumetanide and Captopril.	Hypertension [BA00-BA04]	[32]
Penbutolol	DM4ES8F	Moderate	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Penbutolol.	Hypertension [BA00-BA04]	[18]
Nebivolol	DM7F1PA	Moderate	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Nebivolol.	Hypertension [BA00-BA04]	[18]
Pindolol	DMD2NV7	Moderate	Increased risk of hypertriglyceridemia by the combination of Bumetanide and Pindolol.	Hypertension [BA00-BA04]	[18]
Trichlormethiazide	DMHAQCO	Moderate	Increased risk of fluid/electrolyte loss by the combination of Bumetanide and Trichlormethiazide.	Hypertension [BA00-BA04]	[33]
Hydrochlorothiazide	DMUSZHD	Moderate	Increased risk of fluid/electrolyte loss by the combination of Bumetanide and Hydrochlorothiazide.	Hypertension [BA00-BA04]	[33]
Meclofenamic acid	DM05FXR	Moderate	Antagonize the effect of Bumetanide when combined with Meclofenamic acid.	Inflammatory spondyloarthritis [FA92]	[27]
ITI-007	DMUQ1DO	Moderate	Additive hypotensive effects by the combination of Bumetanide and ITI-007.	Insomnia [7A00-7A0Z]	[25]
Arsenic trioxide	DM61TA4	Major	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Arsenic trioxide.	Mature B-cell lymphoma [2A85]	[34]
Ozanimod	DMT6AM2	Moderate	Additive hypotensive effects by the combination of Bumetanide and Ozanimod.	Multiple sclerosis [8A40]	[29]
Promethazine	DM6I5GR	Moderate	Additive hypotensive effects by the combination of Bumetanide and Promethazine.	Nausea/vomiting [MD90]	[25]
Sibutramine	DMFJTDI	Moderate	Increased risk of hyponatremia by the combination of Bumetanide and Sibutramine.	Obesity [5B80-5B81]	[28]
Polythiazide	DMCH80F	Moderate	Increased risk of fluid/electrolyte loss by the combination of Bumetanide and Polythiazide.	Oedema [MG29]	[33]
Levomethadyl Acetate	DM06HG5	Major	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Levomethadyl Acetate.	Opioid use disorder [6C43]	[35]
Carboplatin	DMG281S	Moderate	Increased risk of ototoxicity by the combination of Bumetanide and Carboplatin.	Ovarian cancer [2C73]	[36]
Ibuprofen	DM8VCBE	Moderate	Antagonize the effect of Bumetanide when combined with Ibuprofen.	Pain [MG30-MG3Z]	[27]
Safinamide	DM0YWJC	Moderate	Additive hypotensive effects by the combination of Bumetanide and Safinamide.	Parkinsonism [8A00]	[29]
Rasagiline	DM3WKQ4	Moderate	Additive hypotensive effects by the combination of Bumetanide and Rasagiline.	Parkinsonism [8A00]	[29]
Bromfenac	DMKB79O	Moderate	Antagonize the effect of Bumetanide when combined with Bromfenac.	Postoperative inflammation [1A00-CA43]	[27]
Levomepromazine	DMIKFEL	Moderate	Additive hypotensive effects by the combination of Bumetanide and Levomepromazine.	Psychotic disorder [6A20-6A25]	[25]
Oxaprozin	DM9UB0P	Moderate	Antagonize the effect of Bumetanide when combined with Oxaprozin.	Rheumatoid arthritis [FA20]	[27]
Quetiapine	DM1N62C	Moderate	Additive hypotensive effects by the combination of Bumetanide and Quetiapine.	Schizophrenia [6A20]	[25]
Mesoridazine	DM2ZGAN	Moderate	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Mesoridazine.	Schizophrenia [6A20]	[36]
Aripiprazole	DM3NUMH	Moderate	Additive hypotensive effects by the combination of Bumetanide and Aripiprazole.	Schizophrenia [6A20]	[25]
Iloperidone	DM6AUFY	Moderate	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Iloperidone.	Schizophrenia [6A20]	[36]
Paliperidone	DM7NPJS	Moderate	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Paliperidone.	Schizophrenia [6A20]	[36]
Molindone	DMAH70G	Moderate	Additive hypotensive effects by the combination of Bumetanide and Molindone.	Schizophrenia [6A20]	[25]
Thiothixene	DMDINC4	Moderate	Additive hypotensive effects by the combination of Bumetanide and Thiothixene.	Schizophrenia [6A20]	[25]
Amisulpride	DMSJVAM	Moderate	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Amisulpride.	Schizophrenia [6A20]	[36]
Asenapine	DMSQZE2	Moderate	Additive hypotensive effects by the combination of Bumetanide and Asenapine.	Schizophrenia [6A20]	[25]
Pimozide	DMW83TP	Major	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Pimozide.	Schizophrenia [6A20]	[37]
Cephapirin	DMV2JNY	Moderate	Increased renal excretion of Bumetanide caused by Cephapirin.	Sepsis [1G40-1G41]	[20]
Plazomicin	DMKMBES	Major	Increased risk of ototoxicity by the combination of Bumetanide and Plazomicin.	Urinary tract infection [GC08]	[21]
Methdilazine	DMAUHQX	Moderate	Additive hypotensive effects by the combination of Bumetanide and Methdilazine.	Vasomotor/allergic rhinitis [CA08]	[25]
Trimeprazine	DMEMV9D	Moderate	Additive hypotensive effects by the combination of Bumetanide and Trimeprazine.	Vasomotor/allergic rhinitis [CA08]	[38]
Amiodarone	DMUTEX3	Major	Increased risk of ventricular arrhythmias by the combination of Bumetanide and Amiodarone.	Ventricular tachyarrhythmia [BC71]	[39]
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⏷ Show the Full List of 81 DDI Information of This Drug

Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug

DIG

DIG Name	DIG ID	PubChem CID	Functional Classification
Allura red AC dye	E00338	33258	Colorant
FD&C blue no. 1	E00263	19700	Colorant
Quinoline yellow WS	E00309	24671	Colorant
Beta-D-lactose	E00099	6134	Diluent; Dry powder inhaler carrier; Lyophilization aid
Eisenoxyd	E00585	56841934	Colorant
Ferric hydroxide oxide yellow	E00539	23320441	Colorant
Ferrosoferric oxide	E00231	14789	Colorant
Magnesium stearate	E00208	11177	lubricant
Talc	E00520	16211421	Anticaking agent; Diluent; Glidant; lubricant
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⏷ Show the Full List of 9 Pharmaceutical Excipients of This Drug

Pharmaceutical Formulation

Formulation Name	Drug Dosage	Dosage Form	Route
Bumetanide 0.5 mg tablet	0.5 mg	Oral Tablet	Oral
Bumetanide 1 mg tablet	1 mg	Oral Tablet	Oral
Bumetanide 2 mg tablet	2 mg	Oral Tablet	Oral

Jump to Detail Pharmaceutical Formulation Page of This Drug

References

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