Details of the Drug Combinations

General Information of This Drug (ID: DMS3GX2)

• Drug Name: Telmisartan (DMS3GX2)
• Synonyms: Kinzal; Kinzalmono; Micardis; Pritor; Abbott brand of telmisartan; Boehringer Ingelheim brand of telmisartan; Glaxo Wellcome brand of telmisartan; GlaxoSmithKline brand of telmisartan; BIBR 277; BIBR 277SE; BIBR-277; BIBR-277SE; Bay 68-9291; Micardis (TN); Telmisartan [USAN:INN]; YM-086; BIBR-277-SE; Telmisartan (JAN/USAN/INN); Micardis, Targit, Temax, BIBR277, Telmisartan; 2-[4-[[4-methyl-6-(1-methylbenzimidazol-2-yl)-2-propylbenzimidazol-1-yl]methyl]phenyl]benzoic acid; 4'-((1,4'-dimethyl-2'-propyl(2,6'-bi-1H-benzimidazol)-1'-yl)methyl)-(1,1'-biphenyl)-2-carboxylic acid; 4'-((4-Methyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimidazolyl)methyl)-2-biphenylcarboxylic acid; 4'-((4-mehtyl-6-(1-methyl-2-benzimidazolyl)-2-propyl-1-benzimmidazolyl)methyl)-2-biphenylcarboxylic acid; 4'-[(1,4'-dimethyl-2'propyl[2,6'-bi-1H-benzimidazol]-1'-yl)methyl]-[1,1'-biphenyl]-2-carboxylic acid; 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl][1,1'-biphenyl]-2-carboxylic acid; 4'-[(1,7'-dimethyl-2'-propyl-1H,3'H-2,5'-bibenzimidazol-3'-yl)methyl]biphenyl-2-carboxylic acid

Indication

Hypertension; ICD 11: BA00-BA04; Status: Approved [1]; Malignant essential hypertension; ICD 11: BA00; Status: Approved [2]; Coronavirus Disease 2019 (COVID-19); ICD 11: 1D6Y; Status: Phase 3 [3]; Stroke; ICD 11: 8B20; Status: Investigative [2]

• Therapeutic Class: Antihypertensive Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

1 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Telmisartan + Idarubicin	DC4SG82	Idarubicin	Glioblastoma? (Cell Line: T98G)	[4]

12 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Amlodipine + Telmisartan	DC0IVRG	Amlodipine	Hypertension	[5]
Atorvastatin + Telmisartan	DC9KH1T	Atorvastatin	Essential Hypertension	[6]
Atorvastatin + Telmisartan	DCYM3GU	Atorvastatin	Diseases of the Circulatory System	[7]
Chlorthalidone + Telmisartan	DCV9A0T	Chlorthalidone	Hypertension	[8]
Levamlodipine + Telmisartan	DCYARH9	Levamlodipine	Hypertension	[9]
Lisinopril + Telmisartan	DCOC4OX	Lisinopril	Kidney, Polycystic	[10]
Telmisartan + Hydrochlorothiazide	DC0UPA1	Hydrochlorothiazide	Hypertension	[11]
Lisinopril + Telmisartan	DC4QOFN	Lisinopril	Kidney, Polycystic	[12]
Rosuvastatin + Telmisartan	DCSVG4B	Rosuvastatin	Hypertension With Hyperlipidemia	[13]
Clonidine + Telmisartan	DCY8FT8	Clonidine	Hypertension	[14]
Rosuvastatin + Telmisartan	DCYY4KO	Rosuvastatin	Metabolic Syndrome	[15]
Telmisartan + Nifedipine	DCB0Z9Q	Nifedipine	Hypertension	[16]

References

• [1] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 592).
• [2] Telmisartan FDA Label
• [3] ClinicalTrials.gov (NCT04359953) Efficacy of Hydroxychloroquine, Telmisartan and Azithromycin on the Survival of Hospitalized Elderly Patients With COVID-19. U.S. National Institutes of Health.
• [4] Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
• [5] ClinicalTrials.gov (NCT00281580) Telmisartan (Micardis) and Amlodipine (Norvasc) - Factorial Design Study for the Treatment of Hypertension
• [6] ClinicalTrials.gov (NCT01842256) Study to Investigate the Effect of Telmisartan/S-amlodipine on the Pharmacokinetic Properties of Atorvastatin.
• [7] ClinicalTrials.gov (NCT02579356) To Evaluate the Drug-drug Interaction Between Telmisartan and Atorvastatin in Healthy Male Volunteers
• [8] ClinicalTrials.gov (NCT01806363) Pharmacokinetic Interactions and Safety Study of Telmisartan and Chlorthalidone
• [9] ClinicalTrials.gov (NCT02250833) CKD-828 (80/5mg) Pharmacokinetic Study
• [10] ClinicalTrials.gov (NCT00283686) HALT Progression of Polycystic Kidney Disease Study A
• [11] ClinicalTrials.gov (NCT01050062) Post-Marketing Surveillance of Micombi Tablets Survey on the Long-term Use
• [12] ClinicalTrials.gov (NCT01885559) HALT Progression of Polycystic Kidney Disease Study B
• [13] ClinicalTrials.gov (NCT03566316) Efficacy/Safety of Telmisartan/Amlodipine/Rosuvastatin in Hypertensive Patients With Hyperlipidemia
• [14] ClinicalTrials.gov (NCT02177461) Telmisartan Compared With Enalapril in Elderly Patients With Blood Hypertension
• [15] ClinicalTrials.gov (NCT02968160) A Clinical Trial of YMC017 in Hypertensive and Hypercholesterolemic Patients With Metabolic Syndrome
• [16] ClinicalTrials.gov (NCT01830530) HIGH Altitude CArdiovascular REsearch in the ANDES