Details of the Drug Combinations

General Information of This Drug (ID: DMSLE03)

Drug Name
PF-562271   DMSLE03
Synonyms PF-00562271
Indication
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

60 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
ATI-17000 + PF-562271 DCTHF06 ATI-17000 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + PF-562271 DCJ8Y4O Bafilomycin A1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bardoxolone methyl + PF-562271 DCGOS5F Bardoxolone methyl Hodgkin lymphoma (Cell Line: U-HO1) [2]
BMS-754807 + PF-562271 DCCI9RO BMS-754807 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
BMS-754807 + PF-562271 DC9Z4S4 BMS-754807 Embryonal rhabdomyosarcoma (Cell Line: SMS-CTR) [2]
BMS-754807 + PF-562271 DCRX6HS BMS-754807 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
BMS-754807 + PF-562271 DC2706X BMS-754807 Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
CF102 + PF-562271 DCNDUT5 CF102 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Crizotinib + PF-562271 DCU6XJM Crizotinib Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
CUDC-101 + PF-562271 DCE9EZD CUDC-101 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Dactinomycin + PF-562271 DC9DMV6 Dactinomycin Diffuse large B cell lymphoma (Cell Line: TMD8) [3]
Dasatinib + PF-562271 DCS1LT2 Dasatinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Dasatinib + PF-562271 DCEC3HW Dasatinib Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Doxorubicin + PF-562271 DCXZWVE Doxorubicin Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Erlotinib + PF-562271 DC5Y27B Erlotinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Evacetrapib + PF-562271 DC92R11 Evacetrapib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Flavopiridol + PF-562271 DCYZEU4 Flavopiridol Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Gemcitabine + PF-562271 DCY79B5 Gemcitabine Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Hydrocortisone + PF-562271 DC48P9H Hydrocortisone Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Ibrutinib + PF-562271 DCXE3QG Ibrutinib Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Idelalisib + PF-562271 DCQVE76 Idelalisib Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
KU-0060648 + PF-562271 DC2X43F KU-0060648 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Larotrectinib + PF-562271 DCHXM9M Larotrectinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
McN3377 + PF-562271 DCHTURN McN3377 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Mebendazole + PF-562271 DCD2R33 Mebendazole Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Mitomycin + PF-562271 DC0LPCV Mitomycin Hodgkin lymphoma (Cell Line: U-HO1) [3]
MK-1775 + PF-562271 DCBFAPA MK-1775 Hodgkin lymphoma (Cell Line: U-HO1) [2]
MK-2206 + PF-562271 DC8C23A MK-2206 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
MK-2206 + PF-562271 DC2X9Q8 MK-2206 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
MK-2206 + PF-562271 DC87DB0 MK-2206 Hodgkin lymphoma (Cell Line: U-HO1) [2]
Palbociclib + PF-562271 DCQCGGA Palbociclib Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
PD-0325901 + PF-562271 DCFMSWD PD-0325901 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
PD-0325901 + PF-562271 DCOOVFX PD-0325901 Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
PF-03772304 + PF-562271 DCZ9V5Z PF-03772304 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
PF-562271 + Panobinostat DCCHJ3G Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PF-562271 + Eltanexor oral DC1JE83 Eltanexor oral Hodgkin lymphoma (Cell Line: U-HO1) [2]
PF-562271 + THAPSIGARGIN DCR3KU9 THAPSIGARGIN Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
PF-562271 + Etoposide DCYE105 Etoposide Hodgkin lymphoma (Cell Line: U-HO1) [2]
PF-562271 + Marizomib DCEWIV5 Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
PF-562271 + Tamoxifen DCOQBIT Tamoxifen Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
PF-562271 + Idarubicin DCK4YJ1 Idarubicin Glioblastoma? (Cell Line: T98G) [2]
PF-562271 + Nintedanib DCJXHP0 Nintedanib Hodgkin lymphoma (Cell Line: U-HO1) [2]
PF-562271 + Tetrahydrouridine DCO71DN Tetrahydrouridine Hodgkin lymphoma (Cell Line: U-HO1) [2]
PF-562271 + PF-562271 DC3S7F8 PF-562271 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-562271 + PF-562271 DCWICJP PF-562271 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
PF-562271 + MK-2206 DC3DD9Z MK-2206 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PF-562271 + MK-2206 DC4P9AN MK-2206 Embryonal rhabdomyosarcoma (Cell Line: RD) [2]
PF-562271 + MK-2206 DCAN7KC MK-2206 Hodgkin lymphoma (Cell Line: U-HO1) [2]
PF-562271 + Ibrutinib DCEJGF7 Ibrutinib Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
PHA-690509 + PF-562271 DCA5DC5 PHA-690509 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
PHA-793887 + PF-562271 DCHNIUG PHA-793887 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
PI-103 + PF-562271 DCQGGEN PI-103 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
Prochlorperazine + PF-562271 DC27Z5B Prochlorperazine Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
RTB101 + PF-562271 DC5X7EN RTB101 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
RTB101 + PF-562271 DCZ6RQ7 RTB101 Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
RTB101 + PF-562271 DCJ4NFR RTB101 Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
THZ1 + PF-562271 DC8BXG8 THZ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Tosyl-l-arginine methyl ester + PF-562271 DC5Y7B8 Tosyl-l-arginine methyl ester Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Venglustat + PF-562271 DCCPRQN Venglustat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Zarnestra + PF-562271 DCOGN22 Zarnestra Diffuse large B cell lymphoma (Cell Line: TMD8) [2]
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References

1 ClinicalTrials.gov (NCT00666926) Study Of PF-00562271, Including Patients With Pancreatic, Head And Neck, Prostatic Neoplasms. U.S. National Institutes of Health.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.