Details of the Drug Combination

General Information of Drug Combination (ID: DC48P9H)

Drug Combination Name
Hydrocortisone PF-562271
Indication
Disease Entry Status REF
Diffuse large B cell lymphoma Investigative [1]
Component Drugs Hydrocortisone   DMGEMB7 PF-562271   DMSLE03
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL
High-throughput Screening Result Testing Cell Line: TMD8
Zero Interaction Potency (ZIP) Score: 17
Bliss Independence Score: 21.55
Loewe Additivity Score: 4.33
LHighest Single Agent (HSA) Score: 9.88

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Hydrocortisone
Disease Entry ICD 11 Status REF
Acne vulgaris ED80 Approved [2]
Acute adrenal insufficiency N.A. Approved [2]
Addison disease 5A74.0 Approved [2]
Allergic rhinitis CA08.0 Approved [2]
Angioedema 4A00.15 Approved [2]
Aspiration pneumonitis N.A. Approved [2]
Autoimmune haemolytic anaemia 3A20 Approved [2]
Blepharoconjunctivitis N.A. Approved [2]
Bursitis N.A. Approved [2]
Cerebral edema 8D60.1 Approved [2]
Corneal abrasion NA06.4 Approved [2]
Corneal ulcer 9A76 Approved [2]
Crohn disease DD70 Approved [2]
Dermatitis herpetiformis EB44 Approved [2]
Diamond-Blackfan anemia N.A. Approved [2]
Disorder of orbital region N.A. Approved [2]
Erythema multiforme N.A. Approved [2]
Exanthem N.A. Approved [2]
Gingival disorder N.A. Approved [2]
Granuloma annulare N.A. Approved [2]
Inflammation 1A00-CA43.1 Approved [3]
Inflammatory bowel disease DD72 Approved [2]
Keratitis N.A. Approved [2]
Malignant otitis externa caused by Pseudomonas aeruginosa N.A. Approved [2]
Multiple sclerosis 8A40 Approved [2]
Mycosis fungoides 2B01 Approved [2]
Primary cutaneous T-cell lymphoma N.A. Approved [2]
Proctitis DB33.Z Approved [2]
Psoriasis EA90 Approved [2]
Psoriatic arthritis FA21 Approved [2]
Rheumatic heart disease N.A. Approved [2]
Rosacea ED90.0 Approved [2]
Sarcoidosis 4B20.5 Approved [2]
Serum sickness N.A. Approved [2]
Severe asthma CA23 Approved [2]
Systemic lupus erythematosus 4A40.0 Approved [2]
Tinea corporis 1F28.Y Approved [2]
Tinea cruris 1F28.3 Approved [2]
Ulcerative colitis DD71 Approved [2]
Viral pneumonia N.A. Approved [2]
Coronavirus Disease 2019 (COVID-19) 1D6Y Phase 3 [4]
Congenital adrenal hyperplasia 5A71.01 Phase 2 [5]
Acquired thrombocytopenia N.A. Investigative [2]
Asthma CA23 Investigative [2]
Beta-thalassemia major N.A. Investigative [2]
Classic Hodgkin lymphoma N.A. Investigative [2]
Iridocyclitis N.A. Investigative [2]
Phobic disorder N.A. Investigative [2]
Rheumatoid arthritis FA20 Investigative [2]
Synovitis N.A. Investigative [2]
Tinea pedis 1F28.2 Investigative [2]
Trichinellosis N.A. Investigative [2]
Uveitis 9A96.Z Investigative [2]
Hydrocortisone Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Glucocorticoid receptor (NR3C1) TTYRL6O GCR_HUMAN Modulator [10]
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Hydrocortisone Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [11]
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Hydrocortisone Interacts with 5 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [12]
Cytochrome P450 3A5 (CYP3A5) DEIBDNY CP3A5_HUMAN Metabolism [13]
Cytochrome P450 3A7 (CYP3A7) DERD86B CP3A7_HUMAN Metabolism [14]
Steroid 11-beta-hydroxylase (CYP11B1) DEPE0RD C11B1_HUMAN Metabolism [15]
Aldosterone synthase (CYP11B2) DE6TYUK C11B2_HUMAN Metabolism [15]
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Hydrocortisone Interacts with 108 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 11B1, mitochondrial (CYP11B1) OTKKL894 C11B1_HUMAN Increases Chemical Synthesis [16]
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases Expression [17]
Cytochrome P450 3A5 (CYP3A5) OTSXFBXB CP3A5_HUMAN Increases Expression [18]
ATP-dependent translocase ABCB1 (ABCB1) OTEJROBO MDR1_HUMAN Increases Secretion [19]
Interleukin-8 (CXCL8) OTS7T5VH IL8_HUMAN Decreases Secretion [20]
Glutathione S-transferase A1 (GSTA1) OTA7K5XA GSTA1_HUMAN Increases Expression [21]
Protein-glutamine gamma-glutamyltransferase K (TGM1) OTB8URRI TGM1_HUMAN Increases Expression [22]
GDH/6PGL endoplasmic bifunctional protein (H6PD) OTO7TNDD G6PE_HUMAN Increases Expression [23]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1) OTO7FJA9 DHI1_HUMAN Increases Expression [23]
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12) OTZKOTDB ADA12_HUMAN Decreases Expression [24]
Mitogen-activated protein kinase kinase kinase 7 (MAP3K7) OTUXEASC M3K7_HUMAN Decreases Expression [24]
Integrin alpha-10 (ITGA10) OTM0V5AO ITA10_HUMAN Increases Expression [24]
Glucocorticoid receptor (NR3C1) OTCI2YDI GCR_HUMAN Decreases Expression [24]
Integrin alpha-5 (ITGA5) OT3RCI67 ITA5_HUMAN Increases Expression [24]
Amine oxidase A (MAOA) OT8NIWMQ AOFA_HUMAN Increases Expression [24]
Insulin-like growth factor-binding protein 5 (IGFBP5) OTRE5V0C IBP5_HUMAN Decreases Expression [24]
Adhesion G protein-coupled receptor E5 (ADGRE5) OTTSB84Q AGRE5_HUMAN Decreases Expression [24]
Metallothionein-1X (MT1X) OT9AKFVS MT1X_HUMAN Increases Expression [24]
Collagen alpha-1(VII) chain (COL7A1) OT3MIRZJ CO7A1_HUMAN Decreases Expression [24]
Forkhead box protein O1 (FOXO1) OTPJRB6D FOXO1_HUMAN Increases Expression [24]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5) OT404F9K FKBP5_HUMAN Increases Expression [24]
Nuclear receptor subfamily 6 group A member 1 (NR6A1) OTFZOOQ9 NR6A1_HUMAN Decreases Expression [24]
Protein prune homolog 2 (PRUNE2) OTGW2974 PRUN2_HUMAN Decreases Expression [24]
Adhesion G-protein coupled receptor G1 (ADGRG1) OTQBB8NT AGRG1_HUMAN Decreases Expression [24]
Cytochrome P450 2S1 (CYP2S1) OTKHX4RF CP2S1_HUMAN Decreases Expression [25]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1) OTNAZVKB 3BHS1_HUMAN Affects Binding [26]
Insulin-like growth factor I (IGF1) OTIIZR61 IGF1_HUMAN Decreases Expression [27]
Insulin-like growth factor 1 receptor (IGF1R) OTXJIF13 IGF1R_HUMAN Affects Expression [27]
CCAAT/enhancer-binding protein beta (CEBPB) OTM9MQIA CEBPB_HUMAN Affects Expression [27]
Steroidogenic acute regulatory protein, mitochondrial (STAR) OTFEZ5AI STAR_HUMAN Decreases Expression [27]
CCAAT/enhancer-binding protein alpha (CEBPA) OTOM9OE4 CEBPA_HUMAN Increases Expression [27]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2) OTHF4H9U DHI2_HUMAN Decreases Expression [27]
Low-density lipoprotein receptor (LDLR) OTH559LU LDLR_HUMAN Decreases Expression [28]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR) OTRT3F3U HMDH_HUMAN Decreases Expression [28]
Apolipoprotein B-100 (APOB) OTH0UOCZ APOB_HUMAN Decreases Expression [28]
RAC-beta serine/threonine-protein kinase (AKT2) OTBB632K AKT2_HUMAN Decreases Expression [28]
Scavenger receptor class B member 1 (SCARB1) OTAE1UA1 SCRB1_HUMAN Decreases Expression [28]
Toll-like receptor 4 (TLR4) OTP7ML3S TLR4_HUMAN Decreases Expression [29]
Basic helix-loop-helix ARNT-like protein 1 (BMAL1) OTMI12L2 BMAL1_HUMAN Decreases Expression [9]
Dihydroxyacetone phosphate acyltransferase (GNPAT) OTF6LWPO GNPAT_HUMAN Increases Expression [7]
ATP-binding cassette sub-family C member 3 (ABCC3) OTC3IJV4 MRP3_HUMAN Increases Expression [30]
Period circadian protein homolog 1 (PER1) OTVQF3WX PER1_HUMAN Increases Expression [9]
Trehalase (TREH) OTJE0NOY TREA_HUMAN Decreases Activity [31]
Toll-like receptor 2 (TLR2) OTGO5P4R TLR2_HUMAN Increases Expression [29]
Rap guanine nucleotide exchange factor 3 (RAPGEF3) OTMOW4Z4 RPGF3_HUMAN Increases Expression [7]
Renin (REN) OT52GZR2 RENI_HUMAN Decreases Expression [32]
Antithrombin-III (SERPINC1) OTDFATG0 ANT3_HUMAN Increases Expression [33]
Natriuretic peptides A (NPPA) OTMQNTNX ANF_HUMAN Increases Expression [34]
Somatotropin (GH1) OT92RTRD SOMA_HUMAN Increases Expression [35]
Pro-neuropeptide Y (NPY) OT4ICV3P NPY_HUMAN Affects Expression [36]
Insulin (INS) OTZ85PDU INS_HUMAN Increases Expression [34]
Tumor necrosis factor (TNF) OT4IE164 TNFA_HUMAN Decreases Expression [9]
Interleukin-1 alpha (IL1A) OTPSGILV IL1A_HUMAN Decreases Expression [9]
Interleukin-1 beta (IL1B) OT0DWXXB IL1B_HUMAN Decreases Expression [37]
Erythropoietin (EPO) OTZ90CN4 EPO_HUMAN Increases Expression [38]
Annexin A1 (ANXA1) OT5OFDJC ANXA1_HUMAN Increases Expression [7]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1) OT2NV3AN CP11A_HUMAN Decreases Expression [39]
Interleukin-6 (IL6) OTUOSCCU IL6_HUMAN Decreases Expression [33]
Kallikrein-1 (KLK1) OTFGP3UR KLK1_HUMAN Increases Export [34]
Prostate-specific antigen (KLK3) OTFGSBFJ KLK3_HUMAN Increases Expression [40]
Involucrin (IVL) OT4VPNGY INVO_HUMAN Decreases Expression [41]
Pulmonary surfactant-associated protein B (SFTPB) OTOHS07E PSPB_HUMAN Increases Expression [42]
Mineralocorticoid receptor (NR3C2) OT0F2V2Z MCR_HUMAN Increases Activity [43]
Monocyte differentiation antigen CD14 (CD14) OT83GJ47 CD14_HUMAN Decreases Expression [29]
C-C motif chemokine 3 (CCL3) OTW2H3ND CCL3_HUMAN Increases Expression [44]
Androgen receptor (AR) OTUBKAZZ ANDR_HUMAN Affects Activity [45]
Pulmonary surfactant-associated protein C (SFTPC) OTIZJD09 PSPC_HUMAN Increases Expression [42]
Proliferating cell nuclear antigen (PCNA) OTHZ1RIA PCNA_HUMAN Decreases Expression [8]
C-C motif chemokine 4 (CCL4) OT6B8P25 CCL4_HUMAN Increases Expression [44]
C-C motif chemokine 2 (CCL2) OTAD2HEL CCL2_HUMAN Decreases Expression [44]
Hepatocyte growth factor (HGF) OTGHUA23 HGF_HUMAN Decreases Expression [46]
Filaggrin (FLG) OTE9QDV6 FILA_HUMAN Decreases Expression [41]
Loricrin (LORICRIN) OTFRPVEO LORI_HUMAN Decreases Expression [41]
NF-kappa-B inhibitor alpha (NFKBIA) OTFT924M IKBA_HUMAN Increases Expression [7]
Dual specificity protein phosphatase 1 (DUSP1) OTN6BR75 DUS1_HUMAN Increases Expression [9]
Cadherin-5 (CDH5) OTVX0E1Q CADH5_HUMAN Increases Localization [7]
T-lymphocyte activation antigen CD80 (CD80) OTJBLUQE CD80_HUMAN Decreases Expression [47]
Catenin beta-1 (CTNNB1) OTZ932A3 CTNB1_HUMAN Increases Localization [7]
Nuclear receptor ROR-alpha (RORA) OTGQT12P RORA_HUMAN Increases Expression [9]
Sterol regulatory element-binding protein 1 (SREBF1) OTWBRPAI SRBP1_HUMAN Increases Expression [48]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A) OTE2KVZV SCNNA_HUMAN Increases Expression [49]
T-lymphocyte activation antigen CD86 (CD86) OTJCSBPC CD86_HUMAN Decreases Expression [47]
Fatty acid synthase (FASN) OTFII9KG FAS_HUMAN Increases Expression [48]
Carnitine O-palmitoyltransferase 1, liver isoform (CPT1A) OTI862QH CPT1A_HUMAN Decreases Expression [48]
Amiloride-sensitive sodium channel subunit beta (SCNN1B) OT61QQTL SCNNB_HUMAN Increases Expression [49]
Amiloride-sensitive sodium channel subunit gamma (SCNN1G) OTSJYQVQ SCNNG_HUMAN Increases Expression [49]
ATP-citrate synthase (ACLY) OTRL9ZRP ACLY_HUMAN Increases Expression [48]
Ras-related protein Rap-1A (RAP1A) OT5RH6TI RAP1A_HUMAN Increases Expression [7]
Tight junction protein ZO-1 (TJP1) OTBDCUPK ZO1_HUMAN Increases Localization [7]
Acetyl-CoA carboxylase 1 (ACACA) OT5CQPZY ACACA_HUMAN Increases Expression [48]
Histone deacetylase 1 (HDAC1) OTQDNOXZ HDAC1_HUMAN Increases Expression [39]
Splicing factor 1 (SF1) OTLEDM2S SF01_HUMAN Decreases Expression [39]
Cryptochrome-1 (CRY1) OTTGAJT0 CRY1_HUMAN Increases Expression [9]
Atypical chemokine receptor 1 (ACKR1) OT9M11LX ACKR1_HUMAN Increases Expression [7]
Occludin (OCLN) OTSUTVWL OCLN_HUMAN Increases Expression [7]
Patatin-like phospholipase domain-containing protein 2 (PNPLA2) OTR3ERMR PLPL2_HUMAN Decreases Expression [48]
NAD-dependent protein deacetylase sirtuin-1 (SIRT1) OTAYZMOY SIR1_HUMAN Decreases Expression [48]
TSC22 domain family protein 3 (TSC22D3) OT03UM03 T22D3_HUMAN Increases Expression [7]
Corticoliberin (CRH) OT2MOC4T CRF_HUMAN Increases Abundance [50]
Oxytocin-neurophysin 1 (OXT) OT48M72Z NEU1_HUMAN Affects Abundance [51]
Aldo-keto reductase family 1 member D1 (AKR1D1) OTBDJ6RL AK1D1_HUMAN Increases Reduction [52]
Angiotensinogen (AGT) OTBZLYR3 ANGT_HUMAN Increases Secretion [53]
Insulin-like growth factor II (IGF2) OTJ4O6MW IGF2_HUMAN Increases Secretion [54]
Histone-binding protein RBBP7 (RBBP7) OTLB56HX RBBP7_HUMAN Affects Response To Substance [55]
Glycodelin (PAEP) OTQA0NV4 PAEP_HUMAN Increases Metabolism [56]
Pro-opiomelanocortin (POMC) OTV41F7T COLI_HUMAN Increases Abundance [57]
T-box transcription factor TBX19 (TBX19) OTXEMR2U TBX19_HUMAN Decreases Abundance [58]
Interferon beta (IFNB1) OTYQGUB5 IFNB_HUMAN Decreases Secretion [54]
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⏷ Show the Full List of 108 DOT(s)
Indication(s) of PF-562271
Disease Entry ICD 11 Status REF
Solid tumour/cancer 2A00-2F9Z Phase 1 [6]
PF-562271 Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Focal adhesion kinase 1 (FAK) TTON5IT FAK1_HUMAN Inhibitor [59]
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2 Hydrocortisone FDA Label
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5 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
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