Details of the Drug Combinations

General Information of This Drug (ID: DMSOURV)

• Drug Name: Formoterol (DMSOURV)
• Synonyms: Foradile; Formoterol tartrate; Oxeze Turbuhaler Foradil; MOLI000351; Atimos (TN); Atock (TN); Foradil (TN); Foradile (TN); Formoterol (INN); Modulite (TN); Oxeze (TN); Oxis (TN); Perforomist (TN); Formoterol, ((R*,R*)-(+-)-)-isomer; N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide; N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide; N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2S)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide; (+-)-2'-Hydroxy-5'-((RS)-1-hydroxy-2-(((RS)-p-methoxy-alpha-methylphenethyl)amino)ethyl)formanilide; 3-formylamino-4-hydroxy-alpha-(N-1-methyl-2-p-methoxyphenethylaminomethyl)benzyl alcohol.hemifumarate

Indication

Allergic asthma; ICD 11: CA23.0; Status: Approved [1]; Asthma; ICD 11: CA23; Status: Approved [2]; Intrinsic asthma; ICD 11: N.A.; Status: Approved [1]; Pulmonary emphysema; ICD 11: CA21.Z; Status: Approved [1]

• Therapeutic Class: Sympathomimetics
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

4 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Lactose + Formoterol	DCVICBD	Lactose	COPD	[3]
Salmeterol + Formoterol	DC5LFA0	Salmeterol	Asthma	[4]
Budesonide + Formoterol	DCIRMI3	Budesonide	Coronavirus Disease 2019 (COVID-19)	[5]
Revefenacin + Formoterol	DC6BKN1	Revefenacin	Chronic Obstructive Pulmonary Disease (COPD)	[6]

5 Approved Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Formoterol + Aclidinium	DCD5U0C	Aclidinium	Chronic obstructive pulmonary disease	[7]
Budesonide + Formoterol	DC45N8S	Budesonide	Asthma	[8]
Formoterol + QMF149	DC4RXC2	QMF149	Asthma	[9]
Formoterol + QMF149	DCRK2PZ	QMF149	Asthma	[10]
Glycopyrrolate + Formoterol	DCXWGE9	Glycopyrrolate	Cough	[9]

References

• [1] Formoterol FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 3465).
• [3] ClinicalTrials.gov (NCT01748279) The Effects of Atorvastatin Treatment in COPD Patients
• [4] ClinicalTrials.gov (NCT01290874) Blacks and Exacerbations on Long Acting Beta Agonists (LABA) vs. Tiotropium (BELT)
• [5] ClinicalTrials.gov (NCT04331470) Evaluation of Efficacy of Levamisole and Formoterol+Budesonide in Treatment of COVID-19. U.S. National Institutes of Health.
• [6] ClinicalTrials.gov (NCT03573817) A 42-day Parallel Group Safety Study of Revefenacin and Formoterol, Administered in Sequence and as a Combination, in Participants With COPD
• [7] Duaklir Genuair approved in the European Union for chronic obstructive pulmonary disease
• [8] Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
• [9] UniProt: the universal protein knowledgebase. Nucleic Acids Res. 2017 Jan 4;45(D1):D158-D169. (ID: O95477)
• [10] ClinicalTrials.gov (NCT02045875) Improving Asthma Control in the Real World: A Systematic Approach to Improving Dulera Adherence. U.S. National Institutes of Health.