Details of the Drug

General Information of Drug (ID: DMSOURV)

• Drug Name: Formoterol
• Synonyms: Foradile; Formoterol tartrate; Oxeze Turbuhaler Foradil; MOLI000351; Atimos (TN); Atock (TN); Foradil (TN); Foradile (TN); Formoterol (INN); Modulite (TN); Oxeze (TN); Oxis (TN); Perforomist (TN); Formoterol, ((R*,R*)-(+-)-)-isomer; N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide; N-[2-hydroxy-5-(1-hydroxy-2-{[1-(4-methoxyphenyl)propan-2-yl]amino}ethyl)phenyl]formamide; N-[2-hydroxy-5-[(1R)-1-hydroxy-2-[[(2S)-1-(4-methoxyphenyl)propan-2-yl]amino]ethyl]phenyl]formamide; (+-)-2'-Hydroxy-5'-((RS)-1-hydroxy-2-(((RS)-p-methoxy-alpha-methylphenethyl)amino)ethyl)formanilide; 3-formylamino-4-hydroxy-alpha-(N-1-methyl-2-p-methoxyphenethylaminomethyl)benzyl alcohol.hemifumarate

Indication

Disease Entry	ICD 11	Status	REF
Allergic asthma	CA23.0	Approved	[1]
Asthma	CA23	Approved	[2]
Intrinsic asthma	N.A.	Approved	[1]
Pulmonary emphysema	CA21.Z	Approved	[1]

• Therapeutic Class: Sympathomimetics
• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 344.4
  Logarithm of the Partition Coefficient (xlogp); 1.8
  Rotatable Bond Count (rotbonds); 8
  Hydrogen Bond Donor Count (hbonddonor); 4
  Hydrogen Bond Acceptor Count (hbondacc); 5
• ADMET Property:
  Absorption AUC: The area under the plot of plasma concentration (AUC) of drug is 0.000081 micromolh/L [3]
  Absorption Tmax: The time to maximum plasma concentration (Tmax) is 0.167-0.5 h [3]
  Bioavailability: The bioavailability of drug is 43% [3]
  Clearance: The renal clearance of drug is 157 mL/min [4]
  Elimination: Following oral administration in 2 healthy subjects, approximately 59-62% and 32-34% of an administered dose was eliminated in the urine and feces, respectively [5]
  Half-life: The concentration or amount of drug in body reduced by one-half in 7 - 10 hours [6]
  Metabolism: The drug is metabolized via the direct glucuronidation of the parent drug and via O-demethylation of the parent drug followed by glucuronidation [4]

Adverse Drug Reaction (ADR)

ADR Term	Variation	Related DOT	DOT ID	REF
Eosinophilic disorders	Not Available	IL5	OTAFPSCO	[7]
Eosinophilic disorders	Not Available	CXCL10 INP10 SCYB10	OTTLQ6S0	[7]
Surgical and medical procedures	Not Available	ADRB2	OTSDOX4Q	[7]

• Chemical Identifiers:
  Formula: C19H24N2O4
  IUPAC Name: N-[2-hydroxy-5-[1-hydroxy-2-[1-(4-methoxyphenyl)propan-2-ylamino]ethyl]phenyl]formamide
  Canonical SMILES: CC(CC1=CC=C(C=C1)OC)NCC(C2=CC(=C(C=C2)O)NC=O)O
  InChI: InChI=1S/C19H24N2O4/c1-13(9-14-3-6-16(25-2)7-4-14)20-11-19(24)15-5-8-18(23)17(10-15)21-12-22/h3-8,10,12-13,19-20,23-24H,9,11H2,1-2H3,(H,21,22)
  InChIKey: BPZSYCZIITTYBL-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 3410
  ChEBI ID: CHEBI:63082
  CAS Number: 73573-87-2
  DrugBank ID: DB00983
  TTD ID: D04KJO
  VARIDT ID: DR01355
  INTEDE ID: DR0744
• Repurposed Drugs (RPD): Click to Jump to the Detailed RPD Information of This Drug

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Adrenergic receptor beta-2 (ADRB2)	TT2CJVK	ADRB2_HUMAN	Agonist	[8]

Drug Transporter (DTP)

DTP Name	DTP ID	UniProt ID	MOA	REF
Organic cation transporter 1 (SLC22A1)	DTT79CX	S22A1_HUMAN	Substrate	[9]

Drug-Metabolizing Enzyme (DME)

DME Name	DME ID	UniProt ID	MOA	REF
Cytochrome P450 2D6 (CYP2D6) Main DME	DECB0K3	CP2D6_HUMAN	Substrate	[10]
Cytochrome P450 2C9 (CYP2C9) Main DME	DE5IED8	CP2C9_HUMAN	Substrate	[11]
Mephenytoin 4-hydroxylase (CYP2C19) Main DME	DEGTFWK	CP2CJ_HUMAN	Substrate	[10]

Drug Off-Target (DOT)

DOT Name	DOT ID	UniProt ID	Interaction	REF
Beta-2 adrenergic receptor (ADRB2)	OTSDOX4Q	ADRB2_HUMAN	Drug Response	[7]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Drug Response	[7]
Interleukin-5 (IL5)	OTAFPSCO	IL5_HUMAN	Drug Response	[7]

Molecular Expression Atlas of This Drug

• The Studied Disease: Allergic asthma
• ICD Disease Classification: CA23.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	4.88E-01	-0.05	-0.12
Adrenergic receptor beta-2 (ADRB2)	DTT	ADRB2	7.10E-01	0.06	0.09
Organic cation transporter 1 (SLC22A1)	DTP	SLC22A1	1.48E-01	6.33E-02	3.20E-01
Organic cation transporter 1 (SLC22A1)	DTP	SLC22A1	1.74E-02	1.21E-01	4.40E-01
Mephenytoin 4-hydroxylase (CYP2C19)	DME	CYP2C19	4.79E-03	1.32E-01	7.85E-01
Mephenytoin 4-hydroxylase (CYP2C19)	DME	CYP2C19	1.82E-01	-1.71E-02	-9.86E-02
Cytochrome P450 2D6 (CYP2D6)	DME	CYP2D6	8.01E-02	6.73E-02	3.36E-01
Cytochrome P450 2D6 (CYP2D6)	DME	CYP2D6	2.91E-04	1.41E-01	6.14E-01
Cytochrome P450 2C9 (CYP2C9)	DME	CYP2C9	7.33E-02	5.59E-02	2.99E-01
Cytochrome P450 2C9 (CYP2C9)	DME	CYP2C9	5.65E-03	-7.28E-02	-1.24E-01

Drug-Drug Interaction (DDI) Information of This Drug

Coadministration of a Drug Treating the Same Disease as Formoterol

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Disease	REF
Budesonide	DMJIBAW	Minor	Increased risk of hypokalemia by the combination of Formoterol and Budesonide.	Asthma [CA23]	[12]

Coadministration of a Drug Treating the Disease Different from Formoterol (Comorbidity)

DDI Drug Name	DDI Drug ID	Severity	Mechanism	Comorbidity	REF
Methylene blue	DMJAPE7	Moderate	Additive hypertensive effects by the combination of Formoterol and Methylene blue.	Acquired methaemoglobinaemia [3A93]	[13]
Ivosidenib	DM8S6T7	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Ivosidenib.	Acute myeloid leukaemia [2A60]	[14]
Midostaurin	DMI6E0R	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Midostaurin.	Acute myeloid leukaemia [2A60]	[14]
Idarubicin	DMM0XGL	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Idarubicin.	Acute myeloid leukaemia [2A60]	[14]
Arn-509	DMT81LZ	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Arn-509.	Acute myeloid leukaemia [2A60]	[14]
Gilteritinib	DMTI0ZO	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Gilteritinib.	Acute myeloid leukaemia [2A60]	[14]
Oliceridine	DM6MDCF	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Oliceridine.	Acute pain [MG31]	[14]
Ivabradine	DM0L594	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Ivabradine.	Angina pectoris [BA40]	[14]
Bepridil	DM0RKS4	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Bepridil.	Angina pectoris [BA40]	[14]
Bedaquiline	DM3906J	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Bedaquiline.	Antimicrobial drug resistance [MG50-MG52]	[14]
Cilostazol	DMZMSCT	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Cilostazol.	Arterial occlusive disease [BD40]	[14]
Posaconazole	DMUL5EW	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Posaconazole.	Aspergillosis [1F20]	[14]
Lisdexamfetamine	DM6W8V5	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Lisdexamfetamine.	Attention deficit hyperactivity disorder [6A05]	[14]
Droxidopa	DM5YF4M	Moderate	Additive hypertensive effects by the combination of Formoterol and Droxidopa.	Autonomic nervous system disorder [8D87]	[15]
Ofloxacin	DM0VQN3	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Ofloxacin.	Bacterial infection [1A00-1C4Z]	[14]
Clarithromycin	DM4M1SG	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Clarithromycin.	Bacterial infection [1A00-1C4Z]	[14]
Gemifloxacin	DMHT34O	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Gemifloxacin.	Bacterial infection [1A00-1C4Z]	[14]
Norfloxacin	DMIZ6W2	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Norfloxacin.	Bacterial infection [1A00-1C4Z]	[14]
Levofloxacin	DMS60RB	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Levofloxacin.	Bacterial infection [1A00-1C4Z]	[14]
Retigabine	DMGNYIH	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Retigabine.	Behcet disease [4A62]	[14]
Eribulin	DM1DX4Q	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Eribulin.	Breast cancer [2C60-2C6Y]	[14]
Lapatinib	DM3BH1Y	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Lapatinib.	Breast cancer [2C60-2C6Y]	[14]
Bosutinib	DMTI8YE	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Bosutinib.	Breast cancer [2C60-2C6Y]	[14]
Corticotropin	DMP9TWZ	Minor	Increased risk of hypokalemia by the combination of Formoterol and Corticotropin.	Chronic kidney disease [GB61]	[12]
PF-04449913	DMSB068	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and PF-04449913.	Chronic myelomonocytic leukaemia [2A40]	[14]
Levomilnacipran	DMV26S8	Moderate	Additive hypertensive effects by the combination of Formoterol and Levomilnacipran.	Chronic pain [MG30]	[16]
Halothane	DM80OZ5	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Halothane.	Corneal disease [9A76-9A78]	[14]
Sevoflurane	DMC9O43	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Sevoflurane.	Corneal disease [9A76-9A78]	[14]
Probucol	DMVZQ2M	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Probucol.	Coronary atherosclerosis [BA80]	[14]
Pasireotide	DMHM7JS	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Pasireotide.	Cushing syndrome [5A70]	[14]
Osilodrostat	DMIJC9X	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Osilodrostat.	Cushing syndrome [5A70]	[14]
Sertraline	DM0FB1J	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Sertraline.	Depression [6A70-6A7Z]	[14]
Selegiline	DM6034S	Moderate	Additive hypertensive effects by the combination of Formoterol and Selegiline.	Depression [6A70-6A7Z]	[13]
Isocarboxazid	DMAF1NB	Moderate	Additive hypertensive effects by the combination of Formoterol and Isocarboxazid.	Depression [6A70-6A7Z]	[13]
Milnacipran	DMBFE74	Moderate	Increased risk of rapid heart rate by the combination of Formoterol and Milnacipran.	Depression [6A70-6A7Z]	[16]
Escitalopram	DMFK9HG	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Escitalopram.	Depression [6A70-6A7Z]	[14]
Desvenlafaxine	DMHD4PE	Moderate	Increased risk of rapid heart rate by the combination of Formoterol and Desvenlafaxine.	Depression [6A70-6A7Z]	[16]
Tetrabenazine	DMYWQ0O	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Tetrabenazine.	Dissociative neurological symptom disorder [6B60]	[14]
Deutetrabenazine	DMUPFLI	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Deutetrabenazine.	Dystonic disorder [8A02]	[14]
Ingrezza	DMVPLNC	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Ingrezza.	Dystonic disorder [8A02]	[14]
Solifenacin	DMG592Q	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Solifenacin.	Functional bladder disorder [GC50]	[14]
Ketoconazole	DMPZI3Q	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Ketoconazole.	Fungal infection [1F29-1F2F]	[14]
Sunitinib	DMCBJSR	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Sunitinib.	Gastrointestinal stromal tumour [2B5B]	[14]
Procarbazine	DMIK367	Moderate	Additive hypertensive effects by the combination of Formoterol and Procarbazine.	Hodgkin lymphoma [2B30]	[13]
Saquinavir	DMG814N	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Saquinavir.	Human immunodeficiency virus disease [1C60-1C62]	[14]
Lopinavir	DMITQS0	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Lopinavir.	Human immunodeficiency virus disease [1C60-1C62]	[17]
Rilpivirine	DMJ0QOW	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Rilpivirine.	Human immunodeficiency virus disease [1C60-1C62]	[14]
Crizotinib	DM4F29C	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Crizotinib.	Lung cancer [2C25]	[14]
Ceritinib	DMB920Z	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Ceritinib.	Lung cancer [2C25]	[14]
Osimertinib	DMRJLAT	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Osimertinib.	Lung cancer [2C25]	[14]
Selpercatinib	DMZR15V	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Selpercatinib.	Lung cancer [2C25]	[14]
Lumefantrine	DM29GAD	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Lumefantrine.	Malaria [1F40-1F45]	[17]
Halofantrine	DMOMK1V	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Halofantrine.	Malaria [1F40-1F45]	[14]
Hydroxychloroquine	DMSIVND	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Hydroxychloroquine.	Malaria [1F40-1F45]	[14]
Primaquine	DMWQ16I	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Primaquine.	Malaria [1F40-1F45]	[14]
Inotuzumab ozogamicin	DMAC130	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Inotuzumab ozogamicin.	Malignant haematopoietic neoplasm [2B33]	[14]
Arsenic trioxide	DM61TA4	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Arsenic trioxide.	Mature B-cell lymphoma [2A85]	[14]
Vemurafenib	DM62UG5	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Vemurafenib.	Melanoma [2C30]	[14]
LGX818	DMNQXV8	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and LGX818.	Melanoma [2C30]	[14]
Panobinostat	DM58WKG	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Panobinostat.	Multiple myeloma [2A83]	[14]
Siponimod	DM2R86O	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Siponimod.	Multiple sclerosis [8A40]	[14]
Fingolimod	DM5JVAN	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Fingolimod.	Multiple sclerosis [8A40]	[14]
Ozanimod	DMT6AM2	Major	Increased risk of ventricular arrhythmias by the combination of Formoterol and Ozanimod.	Multiple sclerosis [8A40]	[18]
Romidepsin	DMT5GNL	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Romidepsin.	Mycosis fungoides [2B01]	[14]
Dasatinib	DMJV2EK	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Dasatinib.	Myeloproliferative neoplasm [2A20]	[14]
Promethazine	DM6I5GR	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Promethazine.	Nausea/vomiting [MD90]	[14]
Entrectinib	DMMPTLH	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Entrectinib.	Non-small cell lung cancer [2C25]	[14]
Sibutramine	DMFJTDI	Moderate	Increased risk of rapid heart rate by the combination of Formoterol and Sibutramine.	Obesity [5B80-5B81]	[19]
Levomethadyl Acetate	DM06HG5	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Levomethadyl Acetate.	Opioid use disorder [6C43]	[17]
Lofexidine	DM1WXA6	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Lofexidine.	Opioid use disorder [6C43]	[14]
Rucaparib	DM9PVX8	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Rucaparib.	Ovarian cancer [2C73]	[14]
Triclabendazole	DMPWGBR	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Triclabendazole.	Parasitic worm infestation [1F90]	[14]
Safinamide	DM0YWJC	Moderate	Additive hypertensive effects by the combination of Formoterol and Safinamide.	Parkinsonism [8A00]	[13]
Rasagiline	DM3WKQ4	Moderate	Additive hypertensive effects by the combination of Formoterol and Rasagiline.	Parkinsonism [8A00]	[13]
Pimavanserin	DMR7IVC	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Pimavanserin.	Parkinsonism [8A00]	[14]
Macimorelin	DMQYJIR	Major	Increased risk of prolong QT interval by the combination of Formoterol and Macimorelin.	Pituitary gland disorder [5A60-5A61]	[20]
Lefamulin	DME6G97	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Lefamulin.	Pneumonia [CA40]	[14]
Degarelix	DM3O8QY	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Degarelix.	Prostate cancer [2C82]	[14]
ABIRATERONE	DM8V75C	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and ABIRATERONE.	Prostate cancer [2C82]	[14]
Enzalutamide	DMGL19D	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Enzalutamide.	Prostate cancer [2C82]	[14]
Relugolix	DMK7IWL	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Relugolix.	Prostate cancer [2C82]	[14]
Bicalutamide	DMZMSPF	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Bicalutamide.	Prostate cancer [2C82]	[14]
Levomepromazine	DMIKFEL	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Levomepromazine.	Psychotic disorder [6A20-6A25]	[14]
Gatifloxacin	DMSL679	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Gatifloxacin.	Respiratory infection [CA07-CA4Z]	[14]
Ciclesonide	DM2NA4K	Minor	Increased risk of hypokalemia by the combination of Formoterol and Ciclesonide.	Respiratory system disease [CB40-CB7Z]	[12]
Dexamethasone	DMMWZET	Minor	Increased risk of hypokalemia by the combination of Formoterol and Dexamethasone.	Rheumatoid arthritis [FA20]	[12]
Quetiapine	DM1N62C	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Quetiapine.	Schizophrenia [6A20]	[14]
Aripiprazole	DM3NUMH	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Aripiprazole.	Schizophrenia [6A20]	[21]
Iloperidone	DM6AUFY	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Iloperidone.	Schizophrenia [6A20]	[14]
Paliperidone	DM7NPJS	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Paliperidone.	Schizophrenia [6A20]	[14]
Amisulpride	DMSJVAM	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Amisulpride.	Schizophrenia [6A20]	[14]
Asenapine	DMSQZE2	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Asenapine.	Schizophrenia [6A20]	[14]
Pimozide	DMW83TP	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Pimozide.	Schizophrenia [6A20]	[14]
LEE011	DMMX75K	Major	Increased risk of prolong QT interval by the combination of Formoterol and LEE011.	Solid tumour/cancer [2A00-2F9Z]	[22]
Vandetanib	DMRICNP	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Vandetanib.	Solid tumour/cancer [2A00-2F9Z]	[14]
Triptorelin	DMTK4LS	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Triptorelin.	Solid tumour/cancer [2A00-2F9Z]	[14]
Doxorubicin	DMVP5YE	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Doxorubicin.	Solid tumour/cancer [2A00-2F9Z]	[14]
Pitolisant	DM8RFNJ	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Pitolisant.	Somnolence [MG42]	[14]
Telavancin	DM58VQX	Moderate	Increased risk of ventricular arrhythmias by the combination of Formoterol and Telavancin.	Staphylococcal/streptococcal disease [1B5Y]	[14]
Cabozantinib	DMIYDT4	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Cabozantinib.	Thyroid cancer [2D10]	[14]
Fluticasone	DMGCSVF	Minor	Increased risk of hypokalemia by the combination of Formoterol and Fluticasone.	Vasomotor/allergic rhinitis [CA08]	[12]
Procainamide	DMNMXR8	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Procainamide.	Ventricular tachyarrhythmia [BC71]	[14]
Flecainide	DMSQDLE	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Flecainide.	Ventricular tachyarrhythmia [BC71]	[14]
Amiodarone	DMUTEX3	Moderate	Increased risk of prolong QT interval by the combination of Formoterol and Amiodarone.	Ventricular tachyarrhythmia [BC71]	[14]

References

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• [12] Agencia Espaola de Medicamentos y Productos Sanitarios Healthcare "Centro de informacion online de medicamentos de la AEMPS - CIMA.".
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• [19] Product Information. Meridia (sibutramine). Knoll Pharmaceutical Company, Whippany, NJ.
• [20] Product Information. Macrilen (macimorelin). Aeterna Zentaris, Charleston, SC.
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• [22] Canadian Pharmacists Association.