Details of the Drug Combinations

General Information of This Drug (ID: DMSV12M)

• Drug Name: Isavuconazole (DMSV12M)
• Synonyms: Isavuconazole; 241479-67-4; isavuconazol; BAL 4815; BAL-4815; UNII-60UTO373KE; Isavuconazole [INN]; 60UTO373KE; Isavuconazole(BAL-4815; RO-0094815); RO 0094815; CHEBI:85979; Isavuconazole (INN); RO-0094815; 4-[2-[(1R,2R)-2-(2,5-Difluorophenyl)-2-hydroxy-1-methyl-3-(1H-1,2,4-triazol-1-yl)propyl]-4-thiazolyl]benzonitrile; 1286730-05-9; 4-[2-[(2R,3R)-3-(2,5-difluorophenyl)-3-hydroxy-4-(1,2,4-triazol-1-yl)butan-2-yl]-1,3-thiazol-4-yl]benzonitrile

Indication

Candidemia; ICD 11: 1F23.3Y; Status: Phase 3 [1]; Invasive aspergillosis; ICD 11: 1F20.0; Status: Phase 3 [1]; Invasive candidiasis; ICD 11: 1F23; Status: Phase 3 [1]

• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

13 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Atorvastatin + Isavuconazole	DCK4EO1	Atorvastatin	Pharmacokinetics of Isavuconazole	[2]
Digoxin + Isavuconazole	DCCPZW3	Digoxin	Pharmacokinetics of Isavuconazole	[3]
Esomeprazole + Isavuconazole	DC6AS4V	Esomeprazole	Pharmacokinetics of Isavuconazole	[4]
Isavuconazole + Methadone	DC4ER67	Methadone	Pharmacokinetics of Isavuconazole	[5]
Isavuconazole + Midazolam	DC6WCDV	Midazolam	Pharmacokinetics of Isavuconazole	[6]
Isavuconazole + Tacrolimus	DCCM5ID	Tacrolimus	Pharmacokinetics of Isavuconazole	[7]
Isavuconazole + Dextromethorphan	DCRO0BE	Dextromethorphan	Pharmacokinetics of Isavuconazole	[8]
Ketoconazole + Isavuconazole	DCL07HC	Ketoconazole	Pharmacokinetics of Isavuconazole	[9]
Lopinavir + Isavuconazole	DC4WEP9	Lopinavir	Pharmacokinetics of Isavuconazole	[10]
Metformin + Isavuconazole	DC8RR3V	Metformin	Pharmacokinetics of Isavuconazole	[11]
Methotrexate + Isavuconazole	DCBTZ9I	Methotrexate	Pharmacokinetics of Isavuconazole	[12]
Warfarin + Isavuconazole	DCKI6Z3	Warfarin	Pharmacokinetics of Isavuconazole	[13]
Acalabrutinib + Isavuconazole	DCL5V3J	Acalabrutinib	Central Nervous System Lymphoma	[14]

References

• [1] ClinicalTrials.gov (NCT00634049) Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi. U.S. National Institutes of Health.
• [2] ClinicalTrials.gov (NCT01635946) Drug Interaction Study of Multiple Doses of Isavuconazole and Single Dose of Atorvastatin
• [3] ClinicalTrials.gov (NCT01582412) Drug Interaction Study of Isavuconazole and Digoxin
• [4] ClinicalTrials.gov (NCT02128893) A Study to Evaluate the Effect of Multiple Doses of Esomeprazole on the Pharmacokinetics of Isavuconazole
• [5] ClinicalTrials.gov (NCT01582425) Drug Interaction Study of Isavuconazole and Methadone
• [6] ClinicalTrials.gov (NCT01406171) Drug Interaction Study of Isavuconazole and Midazolam
• [7] ClinicalTrials.gov (NCT01535547) Drug Interaction Study of Isavuconazole and Tacrolimus
• [8] ClinicalTrials.gov (NCT01651325) Drug Interaction Study of Multiple Doses of Isavuconazole and Single Dose of Dextromethorphan in Healthy Adult Subjects
• [9] ClinicalTrials.gov (NCT01657838) Drug Interaction Study of the Effect of Ketoconazole at Steady State on the Pharmacokinetics of a Single Dose of Isavuconazole in Healthy Adult Subjects
• [10] ClinicalTrials.gov (NCT01660477) Drug-drug Interaction Study Between Lopinavir/Ritonavir and Isavuconazole
• [11] ClinicalTrials.gov (NCT01884558) A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Metformin
• [12] ClinicalTrials.gov (NCT01884636) A Study to Evaluate the Effect of Multiple Doses of Isavuconazole on the Pharmacokinetics of Methotrexate
• [13] ClinicalTrials.gov (NCT01657825) Drug Interaction Study of Isavuconazole and Warfarin in Healthy Male Subjects
• [14] ClinicalTrials.gov (NCT04548648) A Pilot Study of Acalabrutinib in Relapsed/Refractory Primary and Secondary CNS Lymphomas