Details of the Drug Combination

General Information of Drug Combination (ID: DCL07HC)

Drug Combination Name
Ketoconazole Isavuconazole
Indication
Disease Entry Status REF
Pharmacokinetics of Isavuconazole Phase 1 [1]
Component Drugs Ketoconazole   DMPZI3Q Isavuconazole   DMSV12M
Small molecular drug Small molecular drug
2D MOL 2D MOL
3D MOL 3D MOL

Molecular Interaction Atlas of This Drug Combination

Molecular Interaction Atlas (MIA)
Indication(s) of Ketoconazole
Disease Entry ICD 11 Status REF
Blastomycosis 1F22 Approved [2]
Chromomycosis N.A. Approved [2]
Coccidioidomycosis 1F25 Approved [2]
Cutaneous candidiasis 1F23.14 Approved [2]
Fungal infection 1F29-1F2F Approved [3]
Histoplasmosis N.A. Approved [2]
Invasive candidiasis 1F23 Approved [2]
Mycoses 1F2Z Approved [2]
Oral candidiasis 1F23.0 Approved [2]
Paracoccidioidomycosis N.A. Approved [2]
Pityriasis simplex N.A. Approved [2]
Prostate adenocarcinoma N.A. Approved [2]
Tinea corporis 1F28.Y Approved [2]
Tinea cruris 1F28.3 Approved [2]
Tinea versicolor 1F2D.0 Approved [2]
Tinea pedis 1F28.2 Investigative [2]
Ketoconazole Interacts with 1 DTT Molecule(s)
DTT Name DTT ID UniProt ID Mode of Action REF
Candida Cytochrome P450 51 (Candi ERG11) TTTSOUD CP51_CANAL Inhibitor [5]
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Ketoconazole Interacts with 1 DTP Molecule(s)
DTP Name DTP ID UniProt ID Mode of Action REF
P-glycoprotein 1 (ABCB1) DTUGYRD MDR1_HUMAN Substrate [6]
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Ketoconazole Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [7]
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Ketoconazole Interacts with 1 DOT Molecule(s)
DOT Name DOT ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) OTQGYY83 CP3A4_HUMAN Increases ADR [8]
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Indication(s) of Isavuconazole
Disease Entry ICD 11 Status REF
Candidemia 1F23.3Y Phase 3 [4]
Invasive aspergillosis 1F20.0 Phase 3 [4]
Invasive candidiasis 1F23 Phase 3 [4]
Isavuconazole Interacts with 1 DME Molecule(s)
DME Name DME ID UniProt ID Mode of Action REF
Cytochrome P450 3A4 (CYP3A4) DE4LYSA CP3A4_HUMAN Metabolism [9]
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References

1 ClinicalTrials.gov (NCT01657838) Drug Interaction Study of the Effect of Ketoconazole at Steady State on the Pharmacokinetics of a Single Dose of Isavuconazole in Healthy Adult Subjects
2 Ketoconazole FDA Label
3 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2568).
4 ClinicalTrials.gov (NCT00634049) Isavuconazole in the Treatment of Renally Impaired Aspergillosis and Rare Fungi. U.S. National Institutes of Health.
5 Clinical pharmacokinetics and pharmacodynamics of solifenacin. Clin Pharmacokinet. 2009;48(5):281-302.
6 Mammalian drug efflux transporters of the ATP binding cassette (ABC) family in multidrug resistance: A review of the past decade. Cancer Lett. 2016 Jan 1;370(1):153-64.
7 The metabolism of amiodarone by various CYP isoenzymes of human and rat, and the inhibitory influence of ketoconazole. J Pharm Pharm Sci. 2008;11(1):147-59.
8 ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
9 Pharmacokinetic evaluation of CYP3A4-mediated drug-drug interactions of isavuconazole with rifampin, ketoconazole, midazolam, and ethinyl estradiol/norethindrone in healthy adults. Clin Pharmacol Drug Dev. 2017 Jan;6(1):44-53.