Details of the Drug Combinations

General Information of This Drug (ID: DMU3DNC)

• Drug Name: Pentoxifylline (DMU3DNC)
• Synonyms: Agapurin; Azupentat; Dimethyloxohexylxanthine; Durapental; Hemovas; Ikomio; Oxpentifylline; PENTOXYPHYLINE;PNX; Pentoxifilina; Pentoxifyllin; Pentoxifyllinum; Pentoxil; Pentoxiphyllin; Pentoxiphylline; Pentoxiphyllium; Pentoxyfylline; Pentoxyphyllin; Pentoxyphylline; Ralofect; Rentylin; Torental; Trental;Vasofirin; Vazofirin; Agapurin Retard; BL 191; BL191; EHT 0201; EHT0201; IN1161; P 1784; Artal (TN); BL-191; EHT-0201; EHT-201; Flexital (TN); Pentox (TN); Pentoxifilina [INN-Spanish]; Pentoxifyllinum [INN-Latin]; Pentoxil (TN); Pentoxin (TN); Trental (TN); Cis-9-Octadecenoyl coenzyme A; Pentoxifylline [USAN:INN:JAN]; Pentoxifylline (JAN/USP/INN); 1,2,3,6-Tetrahydro-3,7-dimethyl-1-(5-oxohexyl)-2,6-purindion; 1-(5-Oxohexyl)-3,7-dimethylxanthine; 1-(5-Oxohexyl)theobromine; 3,7-Dihydro-3,7-dimethyl-1-(5-oxohexyl)-1H-purine-2,6-dione; 3,7-Dimethyl-1-(5-oxo-hexyl)-3,7-dihydro-purine-2,6-dione; 3,7-Dimethyl-1-(5-oxohexyl) xantine; 3,7-Dimethyl-1-(5-oxohexyl)-1H,3H-purin-2,6-dione; 3,7-Dimethyl-1-(5-oxohexyl)-3,7-dihydro-1H-purine-2,6-dione; 3,7-Dimethyl-1-(5-oxohexyl)xanthine; 3,7-Dimethyl-1-(5-oxohexyl)xantine; 3,7-dimethyl-1-(5-oxohexyl)purine-2,6-dione

Indication

Alcoholic hepatitis; ICD 11: DB94.1; Status: Approved [1]; Intermittent claudication; ICD 11: BD40.00; Status: Approved [2]; Type-1 diabetes; ICD 11: 5A10; Status: Approved [1]; Peripheral vascular disease; ICD 11: BD4Z; Status: Investigative [1]

• Therapeutic Class: Vasodilator Agents
• Drug Type: Small molecular drug

List of Combinatorial Drugs (CBD) Containing This Drug

9 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Carvedilol + Pentoxifylline	DCLHFWX	Carvedilol	Liver Cirrhosis	[3]
Meglumine antimoniate + Pentoxifylline	DCBLTV8	Meglumine antimoniate	Cutaneous Leishmaniasis	[4]
Atorvastatin + Pentoxifylline	DC9X00C	Atorvastatin	Male Erectile Disorder	[5]
Meglumine antimoniate + Pentoxifylline	DCBO7UC	Meglumine antimoniate	Leishmaniasis	[6]
Miltefosine + Pentoxifylline	DC49JTO	Miltefosine	Leishmaniasis	[6]
Paclitaxel + Pentoxifylline	DC0JLGT	Paclitaxel	Breast Cancer Female	[7]
Pentoxifylline + Colchicine	DCJE5ZE	Colchicine	Behçet Disease Affecting Oral Mucosa	[8]
Phenytoin + Pentoxifylline	DCWCRPD	Phenytoin	Epilepsy	[9]
Losartan + Pentoxifylline	DCEBFDN	Losartan	Diabetic Nephropathies	[10]

References

• [1] Pentoxifylline FDA Label
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7095).
• [3] ClinicalTrials.gov (NCT06041932) Pentoxifylline Plus Carvedilol vs Carvedilol Monotherapy in Preventing New Decompensation in Stable Cirrhotic Patients With Prior Decompensation
• [4] ClinicalTrials.gov (NCT01464242) Add-on Study of Pentoxifylline in Cutaneous Leishmaniasis
• [5] ClinicalTrials.gov (NCT03830164) Pentoxifylline, Atorvastatin, and Vitamin E in Treating Patients With Erectile Dysfunction After Radiation Therapy for Prostate Cancer
• [6] ClinicalTrials.gov (NCT02530697) The Association of Miltefosine and Pentoxifylline to Treat Mucosal and Cutaneous Leishmaniasis: A Clinical Trial in Brazil
• [7] ClinicalTrials.gov (NCT05189535) "Prevention of Paclitaxel-Induced Peripheral Neuropathy in Breast Cancer Patients"
• [8] ClinicalTrials.gov (NCT03888846) Topical Pentoxifylline Gel on Behcet's Disease Oral Ulcers
• [9] ClinicalTrials.gov (NCT05637086) Clinical Study Evaluating Safety of Pentoxifylline in Patients With Grand-Mal Epilepsy Treated by Phenytoin Monotherapy
• [10] ClinicalTrials.gov (NCT03006952) Add-on Pentoxifylline to Losartan Versus Increasing Dose of Losartan on NT-PRO BNP in Type 2 Diabetics With Nephropathy