Details of the Drug Combinations

General Information of This Drug (ID: DMUL45H)

Drug Name

Naltrexone DMUL45H

Synonyms

Depotrex; Naltrel; Vivitrex; Vivitrol; Naltrexone Depot; IBS therapy, Pain Therapeutics; Irritable bowel syndrome therapy, Pain Therapeutics; PTI-901; XR-NTX; Naltrexone (sustained release), DAS; Naltrexone (sustained release), elbion; Naltrexone depot (injectable suspension), DrugAbuse Sciences; Naltrexone depot (injectable suspension), elbion; Opioid antagonists (irritable bowel syndrome), Pain Therapeutics; Naltrexone (low-dose), Pain Therapeutics; Naltrexone (polymer microcapsule depot, opioid addiction/alcohol dependency), Biotek; Naltrexone (transdermal, alcohol/opioid dependence), Syntropharma; Naltrexone (once-monthly controlled-release, Medisorb), Alkermes

Indication

Disease Entry	ICD 11	Status	REF
Alcohol dependence	6C40.2	Approved	[1]
Chronic alcoholism	6C40.2Z	Approved	[2]
Crohn disease	DD70	Approved	[3]
Gastroparesis	DA41.00	Approved	[3]
Inflammatory bowel disease	DD72	Approved	[3]
Obesity	5B81	Approved	[3]
Ulcerative colitis	DD71	Approved	[3]
Human immunodeficiency virus infection	1C62	Phase 4	[4]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 2	[5]
Chronic pain	MG30	Investigative	[3]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

82 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Naltrexone	DCU31LM	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Aciclovir + Naltrexone	DCRORYY	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Aliskiren + Naltrexone	DCG3K1I	Aliskiren	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Alvespimycin hydrochloride + Naltrexone	DCJ0J9T	Alvespimycin hydrochloride	DD2 (Cell Line: DD2)	[6]
Atovaquone + Naltrexone	DCBHRFK	Atovaquone	Hepatoblastoma (Cell Line: HB3)	[6]
Auranofin + Naltrexone	DCCX0UP	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Berberine + Naltrexone	DCR154A	Berberine	DD2 (Cell Line: DD2)	[6]
Berberine + Naltrexone	DC51WQC	Berberine	Hepatoblastoma (Cell Line: HB3)	[7]
BIX-01294 + Naltrexone	DCRGPAS	BIX-01294	DD2 (Cell Line: DD2)	[6]
Brincidofovir + Naltrexone	DCY9WWJ	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Carfilzomib + Naltrexone	DCSP3FK	Carfilzomib	Hepatoblastoma (Cell Line: HB3)	[6]
Cefmenoxime + Naltrexone	DCERW5C	Cefmenoxime	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Cerivastatin + Naltrexone	DCRGGQ4	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Chlorzoxazone + Naltrexone	DC6PI31	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Cycloheximide + Naltrexone	DCFF9VM	Cycloheximide	Hepatoblastoma (Cell Line: HB3)	[7]
Dopamine + Naltrexone	DC0NTD6	Dopamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Eltanexor oral + Naltrexone	DCS3051	Eltanexor oral	Hepatoblastoma (Cell Line: HB3)	[7]
Fomepizole + Naltrexone	DCHEOLZ	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
GDC-0084 + Naltrexone	DC7SNNM	GDC-0084	DD2 (Cell Line: DD2)	[6]
GDC-0084 + Naltrexone	DCV2D27	GDC-0084	Hepatoblastoma (Cell Line: HB3)	[7]
Ginsenoside Rb1 + Naltrexone	DC1WOIM	Ginsenoside Rb1	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
GSK2126458 + Naltrexone	DC3M2SQ	GSK2126458	DD2 (Cell Line: DD2)	[6]
Hyodeoxycholic acid + Naltrexone	DC33KYA	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
KN-62 + Naltrexone	DCM1R1U	KN-62	DD2 (Cell Line: DD2)	[6]
KN-62 + Naltrexone	DC7MDE5	KN-62	Hepatoblastoma (Cell Line: HB3)	[7]
Leflunomide + Naltrexone	DCXA9UZ	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Levamisole + Naltrexone	DCTA7EJ	Levamisole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Lumefantrine + Naltrexone	DC96TOL	Lumefantrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Midostaurin + Naltrexone	DCUVUAP	Midostaurin	DD2 (Cell Line: DD2)	[6]
Naltrexone + Meclofenamic acid	DC075YD	Meclofenamic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Ribavirin-TP	DCN010M	Ribavirin-TP	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Gefitinib	DCY17NG	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Dantrolene	DC86N4P	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Ruxolitinib	DCE3WGJ	Ruxolitinib	Hodgkin lymphoma (Cell Line: L-1236)	[6]
Naltrexone + Lumefantrine	DC7YSN9	Lumefantrine	DD2 (Cell Line: DD2)	[6]
Naltrexone + Lumefantrine	DCZOHOX	Lumefantrine	Hepatoblastoma (Cell Line: HB3)	[6]
Naltrexone + Artemether	DC24T9N	Artemether	Hepatoblastoma (Cell Line: HB3)	[6]
Naltrexone + Tacrine	DCDI1WX	Tacrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Methotrexate	DC3XFDU	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Testosterone	DCMODBZ	Testosterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + IT-141	DCCRIBI	IT-141	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Carglumic acid	DCP3QOS	Carglumic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Pazopanib	DCWEANX	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Ciprofibrate	DCN8CV2	Ciprofibrate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Arfolitixorin	DCXID4B	Arfolitixorin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + BIO-300	DCAFQN5	BIO-300	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Niclosamide	DCG5ITJ	Niclosamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Isoproterenol	DCKA08Y	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + GINKGOLIDE A	DCIWR0M	GINKGOLIDE A	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Idarubicin	DC8DF9Y	Idarubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Imatinib	DCA0C6Y	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Bortezomib	DCD004K	Bortezomib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Methylene blue	DC8DIDH	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Methylene blue	DC52CYB	Methylene blue	DD2 (Cell Line: DD2)	[6]
Naltrexone + Methylene blue	DCSU77S	Methylene blue	Hepatoblastoma (Cell Line: HB3)	[6]
Naltrexone + Artemisinin	DCBTS07	Artemisinin	Hepatoblastoma (Cell Line: HB3)	[6]
Naltrexone + Clascoterone	DC23AXG	Clascoterone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Oxyphenbutazone	DCWBCJI	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	DCIN0YA	1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Piperaquine	DCFYA5K	Piperaquine	Hepatoblastoma (Cell Line: HB3)	[6]
Naltrexone + Spironolactone	DCFSKS4	Spironolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Endoxifen	DCO8NEF	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Mycophenolic acid	DC5UJCV	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Pyronaridine	DCIOUWE	Pyronaridine	Hepatoblastoma (Cell Line: HB3)	[6]
Naltrexone + Mefloquine	DCX4YJK	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Doxorubicin	DCONUHN	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Sumatriptan	DCQ80AN	Sumatriptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Olmesartan medoxomil	DC1TPVQ	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Cerivastatin	DC5MRU5	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Busulfan	DCTTWEB	Busulfan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + AS-1949490	DC2614U	AS-1949490	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Naltrexone + Cytarabine	DC1ZS40	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
NITD609 + Naltrexone	DCN9YDS	NITD609	DD2 (Cell Line: DD2)	[6]
Panobinostat + Naltrexone	DC28RVF	Panobinostat	Hepatoblastoma (Cell Line: HB3)	[7]
Pentamidine + Naltrexone	DCFK2KD	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
PMID28460551-Compound-2 + Naltrexone	DCD2HPA	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Proguanil + Naltrexone	DCUD1L2	Proguanil	DD2 (Cell Line: DD2)	[6]
Proguanil + Naltrexone	DCIZMO8	Proguanil	Hepatoblastoma (Cell Line: HB3)	[6]
Pyrazinamide + Naltrexone	DCKLOT4	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Sapanisertib + Naltrexone	DC0UR4E	Sapanisertib	Hepatoblastoma (Cell Line: HB3)	[7]
Sumatriptan + Naltrexone	DC5QZMU	Sumatriptan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
Testosterone cypionate + Naltrexone	DCAS2MY	Testosterone cypionate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[6]
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⏷ Show the Full List of 82 DrugCom(s)

20 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Buprenorphine + Naltrexone	DCRABL2	Buprenorphine	ECG Effects	[8]
Bupropion + Naltrexone	DCQFAHU	Bupropion	Smoking	[9]
Bupropion + Naltrexone	DCEVL3P	Bupropion	Obesity	[10]
Disulfiram + Naltrexone	DC0PPRT	Disulfiram	Alcohol-Related Disorders	[11]
Fentanyl + Naltrexone	DCID1BL	Fentanyl	Pain, Postoperative	[12]
Memantine + Naltrexone	DC3NFUF	Memantine	Opioid Dependence	[13]
Naltrexone + Desipramine	DC38J3R	Desipramine	Alcoholism	[14]
Naltrexone + Modafinil	DCAUHEP	Modafinil	Alcohol-Related Disorders	[15]
Paroxetine + Naltrexone	DCO3W41	Paroxetine	Alcoholism	[14]
Propranolol + Naltrexone	DCC2RVR	Propranolol	Advanced Melanoma	[16]
Sertraline + Naltrexone	DCV9XSZ	Sertraline	Alcoholism	[17]
Varenicline + Naltrexone	DCBLL76	Varenicline	Smoking	[18]
Bupropion + Naltrexone	DC6OC31	Bupropion	Binge Drinking	[19]
Ketamine + Naltrexone	DC71OWP	Ketamine	COVID-19	[5]
Ketamine + Naltrexone	DCVFSTI	Ketamine	Obsessive-Compulsive Disorder	[20]
Naltrexone + Colchicine	DCIFQFH	Colchicine	Covid19	[21]
Prazosin + Naltrexone	DCLRE8B	Prazosin	Alcohol Use Disorder	[22]
Buprenorphine + Naltrexone	DCRW42T	Buprenorphine	Opioid Use Disorder	[23]
Lemborexant + Naltrexone	DCT8Y39	Lemborexant	Alcohol Use Disorder	[24]
Naltrexone + Norethindrone	DCP2KS5	Norethindrone	Endometriosis	[25]
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⏷ Show the Full List of 20 DrugCom(s)

References

1	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. 2015
2	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 074918.
3	Naltrexone FDA Label
4	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 1639).
5	ClinicalTrials.gov (NCT04365985) Study of Immunomodulation Using Naltrexone and Ketamine for COVID-19. U.S. National Institutes of Health.
6	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
7	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
8	ClinicalTrials.gov (NCT01999114) The Effect of Buprenorphine Delivered by Buprenorphine Transdermal System (BTDS) at Doses up to 80 Micrograms/Hour (mcg/hr) and Naltrexone on Electrocardiogram (ECG) Intervals in Healthy Volunteers
9	ClinicalTrials.gov (NCT00129246) Low-Dose Naltrexone Combined With Bupropion to Stop Smoking With Less Weight Gain
10	A randomized, phase 3 trial of naltrexone SR/bupropion SR on weight and obesity-related risk factors (COR-II). Obesity (Silver Spring). 2013 May;21(5):935-43.
11	ClinicalTrials.gov (NCT00142844) Combination of Disulfiram Plus Naltrexone to Treat Both Cocaine- and Alcohol-dependent Individuals - 1
12	ClinicalTrials.gov (NCT01750060) Pharmacokinetic Characterization of the Active, Separated System With PK Controller (Fentanyl Iontophoretic Transdermal System, 40 Mcg Fentanyl Per Activation).
13	ClinicalTrials.gov (NCT00125515) Memantine and Naltrexone Treatment for Opioid Dependence
14	ClinicalTrials.gov (NCT00338962) Naltrexone & SSRI in Alcoholics With Depression/PTSD
15	ClinicalTrials.gov (NCT00142818) Modafinil and Naltrexone to Reduce Cocaine and Alcohol Dependence
16	ClinicalTrials.gov (NCT05968690) Naltrexone and Propranolol Combined With Immunotherapy
17	ClinicalTrials.gov (NCT00000451) Drug Therapy for Alcohol Dependence in Alaska Natives (Naltrexone/Sertraline)
18	ClinicalTrials.gov (NCT00502216) Naltrexone and Varenicline: Weight Gain and Tolerability in Cigarette Smokers
19	ClinicalTrials.gov (NCT02842073) An Open Label Trial of Bupropion and Naltrexone for Binge Drinking
20	ClinicalTrials.gov (NCT05940324) Examining Mu Opioid Mechanisms of Ketamine's Rapid Effects in OCD (MKET2)
21	ClinicalTrials.gov (NCT04756128) Impact of Colchicine and Low-dose Naltrexone on COVID-19
22	ClinicalTrials.gov (NCT02322047) Prazosin and Naltrexone (PaN) Study for Veterans With Alcohol Use Disorders
23	ClinicalTrials.gov (NCT02696434) Evaluating Naltrexone for Use in Conjunction With Buprenorphine in Adults With Opioid Use Disorder Transitioning From Buprenorphine Maintenance Prior to First Dose of VIVITROL
24	ClinicalTrials.gov (NCT05458609) Lemborexant Augmentation of Naltrexone for Alcohol Craving and Sleep
25	ClinicalTrials.gov (NCT03970330) Low-Dose Naltrexone in Combination With Standard Treatment in Women With Endometriosis