General Information of This Drug (ID: DMUNK59)

Drug Name
Bafilomycin A1   DMUNK59
Synonyms
bafilomycin A1; 88899-55-2; MFCD06795130; CHEMBL290814; CHEBI:22689; (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-{(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-6-isopropyl-5-methyltetrahydro-2H-pyran-2-yl]-3-hydroxypentan-2-yl}-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyloxacyclohexadeca-3,5,11,13-tetraen-2-one; Bafilomycin; NSC381866; Bafilomycin A1/; Hygrolidin, 21-O-de(3-carboxy-1-oxo-2-propenyl)-2-demethyl-2-methoxy-24-methyl-; Bafilomycin A1 from Streptomyces griseus; BSPBio_001470; MEGxm0_000385; SCHEMBL13775181; ACon0_000813; HMS3402J12; Bafilomycin A1 Ready Made Solution; ABP000610; BDBM50064186; AKOS030213158; ZINC169647947; DB06733; MCULE-2359469972; NCGC00163426-02; (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(2S,3R,4S)-4-[(2R,4R,5S,6R)-2,4-dihydroxy-5-methyl-6-propan-2-yloxan-2-yl]-3-hydroxypentan-2-yl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one; Q4841341; (3Z,5E,7R,8S,9S,11E,13E,15S,16R)-16-[(1S,2R,3S)-3-[(2R,4R,5S,6R)-2,4-dihydroxy-6-isopropyl-5-methyl-tetrahydropyran-2-yl]-2-hydroxy-1-methyl-butyl]-8-hydroxy-3,15-dimethoxy-5,7,9,11-tetramethyl-1-oxacyclohexadeca-3,5,11,13-tetraen-2-one
Indication
Disease Entry ICD 11 Status REF
B-cell acute lymphoblastic leukaemia 2B33.3 Investigative [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

32 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Bafilomycin A1 + Clindamycin DCCKVZR Clindamycin DD2 (Cell Line: DD2) [2]
Bafilomycin A1 + Buparlisib DCGC2BD Buparlisib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + AT13387 DC4U4DM AT13387 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + JQ1 DCYTHU4 JQ1 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + PMID28460551-Compound-2 DCAD9E1 PMID28460551-Compound-2 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Crizotinib DCY02OX Crizotinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Panobinostat DCZF6FC Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + LY2835219 DCUI17H LY2835219 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + SCH 727965 DC5JJCS SCH 727965 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Marizomib DC1JU7S Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Vincristine DCOFGY1 Vincristine Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Ridaforolimus DCM8MFA Ridaforolimus Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Mebendazole DCZ5NSL Mebendazole Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Chloroquine DC3IHOV Chloroquine DD2 (Cell Line: DD2) [2]
Bafilomycin A1 + PF-562271 DCJ8Y4O PF-562271 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Piperaquine DC149GM Piperaquine DD2 (Cell Line: DD2) [2]
Bafilomycin A1 + AZD8330 DCQNSOW AZD8330 Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Pyronaridine DCX33QU Pyronaridine DD2 (Cell Line: DD2) [2]
Bafilomycin A1 + Mefloquine DCT1CR2 Mefloquine DD2 (Cell Line: DD2) [2]
Bafilomycin A1 + Doxorubicin DCCWL56 Doxorubicin Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Vorinostat DCLGX3G Vorinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + GDC-0077 DCVLGBA GDC-0077 DD2 (Cell Line: DD2) [2]
Bafilomycin A1 + Dasatinib DCMFQ2C Dasatinib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Bafilomycin A1 + Ruxolitinib DC9OA86 Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [3]
Bafilomycin A1 + Lumefantrine DC6UBW5 Lumefantrine Hepatoblastoma (Cell Line: HB3) [3]
Bafilomycin A1 + NITD609 DCMMMAB NITD609 Hepatoblastoma (Cell Line: HB3) [3]
Bafilomycin A1 + Chloroquine DCGVWS4 Chloroquine Hepatoblastoma (Cell Line: HB3) [3]
Bafilomycin A1 + Piperaquine DC087JS Piperaquine Hepatoblastoma (Cell Line: HB3) [3]
Bafilomycin A1 + Atovaquone DCTOJ27 Atovaquone Hepatoblastoma (Cell Line: HB3) [3]
Emetine + Bafilomycin A1 DCXBO4Z Emetine DD2 (Cell Line: DD2) [2]
Evacetrapib + Bafilomycin A1 DCCEXIL Evacetrapib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
THAPSIGARGIN + Bafilomycin A1 DCM6BM8 THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
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⏷ Show the Full List of 32 DrugCom(s)

References

1 Bafilomycin A1 targets both autophagy and apoptosis pathways in pediatric B-cell acute lymphoblastic leukemia. Haematologica. 2015 Mar;100(3):345-56.
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.