Details of the Drug Combinations

General Information of This Drug (ID: DMUY35B)

Drug Name

Progesterone DMUY35B

Synonyms

progesterone; 57-83-0; Agolutin; Pregn-4-ene-3,20-dione; Luteohormone; Crinone; 4-Pregnene-3,20-dione; Utrogestan; Syngesterone; Progestin; Luteol; Corpus luteum hormone; Progesterol; Progesteronum; Pregnenedione; Glanducorpin; Prometrium; Corlutin; Cyclogest; Progestron; Gestormone; Progestone; Gestone; Progestasert; Progestronol; Methylpregnone; Hormoflaveine; Syngestrets; Proluton; Progekan; Nalutron; Lutoform; Gynlutin; Gesterol; Fologenon; Corporin; Corlutina; Syntolutan; Prolidon; Membrettes; Lutocyclin; Luteodyn; Lucorteum; Corluvite; LPCN-1107; Progesterone (oral, preterm labor); Progesterone (oral, preterm labor), Lipocine

Indication

Disease Entry	ICD 11	Status	REF
Amenorrhea	GA20.0	Approved	[1]
Hot flushes	GA30	Approved	[2]
Premature labour	JB00	Approved	[3]
Contraception	QA21	Phase 3	[4]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1	[5]
Endometrial carcinoma	N.A.	Investigative	[2]
Endometriosis	GA10	Investigative	[2]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

11 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Leuprolide + Progesterone	DC87F2J	Leuprolide	Coronary Heart Disease	[6]
Progesterone + Flutamide	DC8AEJB	Flutamide	Polycystic Ovary Syndrome	[7]
Progesterone + Estradiol	DCHEF2V	Estradiol	Postpartum Depression	[8]
Progesterone + Aspirin	DCRBHOT	Aspirin	Preeclampsia	[9]
Elagolix + Progesterone	DCCTODU	Elagolix	Heavy Uterine Bleeding	[10]
Progesterone + Ibutilide	DCPV6RQ	Ibutilide	Prolonged QT Interval in EKG and Sudden Death	[11]
Progesterone + Estetrol	DCS1U60	Estetrol	Vasomotor Symptoms	[12]
Dydrogesterone + Progesterone	DCSXPGG	Dydrogesterone	Infertility	[13]
Estradiol valerate + Progesterone	DC2X44S	Estradiol valerate	Infertility	[14]
Estradiol valerate + Progesterone	DCHNIUN	Estradiol valerate	Infertility	[14]
Progesterone + Ibutilide	DCGQYHX	Ibutilide	Long QT Syndrome	[15]
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References

1	FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 075906.
2	Progesterone FDA Label
3	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2377).
4	ClinicalTrials.gov (NCT00822900) Progesterone for the Treatment of Traumatic Brain Injury III. U.S. National Institutes of Health.
5	ClinicalTrials.gov (NCT04365127) Progesterone for the Treatment of COVID-19 in Hospitalized Men. U.S. National Institutes of Health.
6	ClinicalTrials.gov (NCT01546454) Relationship Between the Menstrual Cycle and Heart Disease in Women
7	ClinicalTrials.gov (NCT01428193) Effects of Androgen Blockade on Sensitivity of the GnRH Pulse Generator to Suppression by Estradiol and Progesterone
8	ClinicalTrials.gov (NCT00001481) The Role of Hormones in Postpartum Mood Disorders
9	ClinicalTrials.gov (NCT00719537) Oral Progesterone and Low Dose Aspirin in the Prevention of Preeclampsia
10	ClinicalTrials.gov (NCT01441635) Safety and Efficacy of Elagolix in Pre-Menopausal Women With Heavy Uterine Bleeding and Uterine Fibroids
11	ClinicalTrials.gov (NCT01929083) Influence of Progesterone Administration on Drug-Induced QT Interval Lengthening
12	ClinicalTrials.gov (NCT04209543) Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)
13	ClinicalTrials.gov (NCT03858049) Efficacy and Safety of Crinone Versus Combination Medication (ACCESS)
14	ClinicalTrials.gov (NCT02655146) the Effects of GnRHa Add up to Routine Luteal Phase Support on Frozen Embryo Implantation in Frozen Embryo Transfer .
15	ClinicalTrials.gov (NCT03834883) Reducing the Risk of Drug-Induced QT Interval Lengthening in Women