Details of the Drug Combination

General Information of Drug Combination (ID: DCS1U60)

• Drug Combination Name: Progesterone + Estetrol
• Indication: Vasomotor Symptoms; Status: Phase 3 [1]
• Component Drugs:
  Progesterone (DMUY35B): Small molecular drug
  Estetrol (DMTB63Q): Small molecular drug

Molecular Interaction Atlas of This Drug Combination

Indication(s) of Progesterone

Disease Entry	ICD 11	Status	REF
Amenorrhea	GA20.0	Approved	[2]
Hot flushes	GA30	Approved	[3]
Premature labour	JB00	Approved	[4]
Contraception	QA21	Phase 3	[5]
Coronavirus Disease 2019 (COVID-19)	1D6Y	Phase 1	[6]
Endometrial carcinoma	N.A.	Investigative	[3]
Endometriosis	GA10	Investigative	[3]

Progesterone Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Progesterone receptor (PGR)	TTUV8G9	PRGR_HUMAN	Agonist	[23]

Progesterone Interacts with 2 DTP Molecule(s)

DTP Name	DTP ID	UniProt ID	Mode of Action	REF
P-glycoprotein 1 (ABCB1)	DTUGYRD	MDR1_HUMAN	Substrate	[24]
Breast cancer resistance protein (ABCG2)	DTI7UX6	ABCG2_HUMAN	Substrate	[25]

Progesterone Interacts with 17 DME Molecule(s)

DME Name	DME ID	UniProt ID	Mode of Action	REF
Cytochrome P450 3A4 (CYP3A4)	DE4LYSA	CP3A4_HUMAN	Metabolism	[26]
Cytochrome P450 2A6 (CYP2A6)	DEJVYAZ	CP2A6_HUMAN	Metabolism	[27]
Cytochrome P450 1A1 (CYP1A1)	DE6OQ3W	CP1A1_HUMAN	Metabolism	[28]
Sulfotransferase 1A1 (SULT1A1)	DEYWLRK	ST1A1_HUMAN	Metabolism	[29]
Cytochrome P450 2D6 (CYP2D6)	DECB0K3	CP2D6_HUMAN	Metabolism	[30]
Cytochrome P450 4B1 (CYP4B1)	DEMF740	CP4B1_HUMAN	Metabolism	[31]
Glutathione S-transferase alpha-1 (GSTA1)	DE4ZHS1	GSTA1_HUMAN	Metabolism	[32]
Cytochrome P450 3A5 (CYP3A5)	DEIBDNY	CP3A5_HUMAN	Metabolism	[33]
Cytochrome P450 3A7 (CYP3A7)	DERD86B	CP3A7_HUMAN	Metabolism	[34]
Cytochrome P450 2C9 (CYP2C9)	DE5IED8	CP2C9_HUMAN	Metabolism	[35]
Mephenytoin 4-hydroxylase (CYP2C19)	DEGTFWK	CP2CJ_HUMAN	Metabolism	[35]
Cytochrome P450 1B1 (CYP1B1)	DE9QHP6	CP1B1_HUMAN	Metabolism	[36]
Cholesterol 24-hydroxylase (CYP46A1)	DEKP5HX	CP46A_HUMAN	Metabolism	[37]
Steroid 21-hydroxylase (CYP21A2)	DE0JMZ5	CP21A_HUMAN	Metabolism	[38]
Aldo-keto reductase 1C1 (AKR1C1)	DE7P2FB	AK1C1_HUMAN	Metabolism	[39]
Cytochrome P450 MEG (cyp106)	DEZ1H4L	CPXM_BACME	Metabolism	[40]
Cytochrome P450 21A2 (cyp21)	DEBY951	A0A250VKS1_STROL	Metabolism	[41]

Progesterone Interacts with 1133 DOT Molecule(s)

DOT Name	DOT ID	UniProt ID	Mode of Action	REF
Glutathione S-transferase A1 (GSTA1)	OTA7K5XA	GSTA1_HUMAN	Increases Chemical Synthesis	[42]
Cytochrome P450 3A4 (CYP3A4)	OTQGYY83	CP3A4_HUMAN	Increases Expression	[43]
Aldo-keto reductase family 1 member C1 (AKR1C1)	OTQKR4CM	AK1C1_HUMAN	Decreases Expression	[44]
Cytochrome P450 1B1 (CYP1B1)	OTYXFLSD	CP1B1_HUMAN	Decreases Expression	[9]
Cytochrome P450 3A5 (CYP3A5)	OTSXFBXB	CP3A5_HUMAN	Increases Expression	[43]
Cytochrome P450 2A6 (CYP2A6)	OT52TWG3	CP2A6_HUMAN	Increases Expression	[43]
Cytochrome P450 4B1 (CYP4B1)	OTJP46CB	CP4B1_HUMAN	Increases Expression	[8]
Cytochrome P450 1A1 (CYP1A1)	OTE4EFH8	CP1A1_HUMAN	Increases Hydroxylation	[28]
Cytochrome P450 2C19 (CYP2C19)	OTFMJYYE	CP2CJ_HUMAN	Increases Hydroxylation	[45]
Cholesterol 24-hydroxylase (CYP46A1)	OTJ27FOX	CP46A_HUMAN	Increases Hydroxylation	[37]
Broad substrate specificity ATP-binding cassette transporter ABCG2 (ABCG2)	OTW8V2V1	ABCG2_HUMAN	Decreases Activity	[46]
ATP-dependent translocase ABCB1 (ABCB1)	OTEJROBO	MDR1_HUMAN	Increases Expression	[47]
Mitogen-activated protein kinase 1 (MAPK1)	OTH85PI5	MK01_HUMAN	Decreases Phosphorylation	[48]
Mitogen-activated protein kinase 3 (MAPK3)	OTCYKGKO	MK03_HUMAN	Decreases Phosphorylation	[48]
Angiotensinogen (AGT)	OTBZLYR3	ANGT_HUMAN	Decreases Secretion	[49]
Progonadoliberin-1 (GNRH1)	OTH8A44K	GON1_HUMAN	Decreases Abundance	[50]
Aryl hydrocarbon receptor (AHR)	OTFE4EYE	AHR_HUMAN	Affects Binding	[51]
Solute carrier family 22 member 1 (SLC22A1)	OT7817I4	S22A1_HUMAN	Decreases Activity	[52]
Solute carrier family 22 member 3 (SLC22A3)	OTQYGVXX	S22A3_HUMAN	Decreases Activity	[52]
RAC-alpha serine/threonine-protein kinase (AKT1)	OT8H2YY7	AKT1_HUMAN	Increases Phosphorylation	[53]
Nuclear receptor subfamily 1 group I member 2 (NR1I2)	OTC5U0N5	NR1I2_HUMAN	Increases Activity	[54]
ATP-binding cassette sub-family C member 2 (ABCC2)	OTJSIGV5	MRP2_HUMAN	Decreases Activity	[55]
Fatty-acid amide hydrolase 1 (FAAH)	OT9DX3N1	FAAH1_HUMAN	Increases Expression	[56]
Catechol O-methyltransferase (COMT)	OTPWKTQG	COMT_HUMAN	Decreases Expression	[57]
Tumor necrosis factor receptor superfamily member 11B (TNFRSF11B)	OTQ4W7MT	TR11B_HUMAN	Decreases Expression	[8]
Claudin-5 (CLDN5)	OTUX60YO	CLD5_HUMAN	Increases Expression	[8]
Nuclear factor 1 B-type (NFIB)	OTX94PD0	NFIB_HUMAN	Increases Expression	[8]
Ectoderm-neural cortex protein 1 (ENC1)	OTJEUB6U	ENC1_HUMAN	Decreases Expression	[8]
PDZ domain-containing protein 2 (PDZD2)	OTPPVRGY	PDZD2_HUMAN	Increases Expression	[8]
RIMS-binding protein 2 (RIMBP2)	OTUNSVUJ	RIMB2_HUMAN	Increases Expression	[8]
Synaptojanin-2 (SYNJ2)	OTLRHXP1	SYNJ2_HUMAN	Decreases Expression	[8]
Low-density lipoprotein receptor class A domain-containing protein 4 (LDLRAD4)	OTQUX50Z	LRAD4_HUMAN	Increases Expression	[8]
25-hydroxyvitamin D-1 alpha hydroxylase, mitochondrial (CYP27B1)	OTTK98BH	CP27B_HUMAN	Decreases Expression	[8]
Cytochrome P450 26A1 (CYP26A1)	OTL1DFWV	CP26A_HUMAN	Increases Expression	[8]
Aldo-keto reductase family 1 member B10 (AKR1B10)	OTOA4HTH	AK1BA_HUMAN	Decreases Expression	[8]
Gremlin-1 (GREM1)	OTCK4IGV	GREM1_HUMAN	Decreases Expression	[8]
Toll-like receptor 2 (TLR2)	OTGO5P4R	TLR2_HUMAN	Increases Expression	[8]
Dual specificity protein phosphatase CDC14B (CDC14B)	OTAESVOZ	CC14B_HUMAN	Increases Expression	[8]
Transcription factor Maf (MAF)	OT1GR3IZ	MAF_HUMAN	Increases Expression	[8]
Cytokine receptor-like factor 1 (CRLF1)	OT55PXIN	CRLF1_HUMAN	Increases Expression	[8]
Mammaglobin-B (SCGB2A1)	OT9L87U9	SG2A1_HUMAN	Increases Expression	[8]
CCN family member 5 (CCN5)	OTADU8JJ	CCN5_HUMAN	Decreases Expression	[8]
Interleukin-33 (IL33)	OTT5YWK3	IL33_HUMAN	Decreases Expression	[8]
Integrin beta-like protein 1 (ITGBL1)	OTJDHE17	ITGBL_HUMAN	Increases Expression	[8]
Secretoglobin family 1D member 1 (SCGB1D1)	OTA20BF2	SG1D1_HUMAN	Increases Expression	[8]
Secretoglobin family 1D member 2 (SCGB1D2)	OTSYWZAQ	SG1D2_HUMAN	Increases Expression	[8]
Actin-associated protein FAM107A (FAM107A)	OTBG61YZ	F107A_HUMAN	Increases Expression	[8]
Urokinase-type plasminogen activator (PLAU)	OTX0QGKK	UROK_HUMAN	Decreases Expression	[8]
Carbonic anhydrase 2 (CA2)	OTJRMUAG	CAH2_HUMAN	Decreases Expression	[8]
Platelet-derived growth factor subunit B (PDGFB)	OTMFMFC3	PDGFB_HUMAN	Decreases Expression	[8]
Keratin, type II cytoskeletal 6A (KRT6A)	OT392M5T	K2C6A_HUMAN	Increases Expression	[8]
Retinol-binding protein 4 (RBP4)	OTL9RBH5	RET4_HUMAN	Increases Expression	[8]
Alpha-1-acid glycoprotein 1 (ORM1)	OTZKSBRE	A1AG1_HUMAN	Decreases Expression	[8]
Trefoil factor 1 (TFF1)	OTCYQH4F	TFF1_HUMAN	Decreases Expression	[8]
Keratin, type II cytoskeletal 6B (KRT6B)	OTBXJYHY	K2C6B_HUMAN	Increases Expression	[8]
Apolipoprotein D (APOD)	OTT77XW8	APOD_HUMAN	Increases Expression	[8]
Integrin beta-3 (ITGB3)	OTWCK1K6	ITB3_HUMAN	Decreases Expression	[8]
Plasminogen activator inhibitor 2 (SERPINB2)	OT72QLZB	PAI2_HUMAN	Decreases Expression	[8]
Plasminogen activator inhibitor 1 (SERPINE1)	OTT0MPQ3	PAI1_HUMAN	Increases Expression	[8]
Alkaline phosphatase, placental type (ALPP)	OTZU4G9W	PPB1_HUMAN	Increases Expression	[8]
Carcinoembryonic antigen-related cell adhesion molecule 5 (CEACAM5)	OTREV92I	CEAM5_HUMAN	Decreases Expression	[8]
Thrombomodulin (THBD)	OT8VHLKY	TRBM_HUMAN	Increases Expression	[8]
Insulin-like growth factor-binding protein 1 (IGFBP1)	OT6UQV2K	IBP1_HUMAN	Increases Expression	[8]
Neuromedin-B (NMB)	OT4NLN6H	NMB_HUMAN	Decreases Expression	[8]
Serum amyloid A-2 protein (SAA2)	OTYAVJWG	SAA2_HUMAN	Increases Expression	[8]
Alpha-amylase 1B (AMY1A)	OT6G4B8O	AMY1B_HUMAN	Increases Expression	[8]
Chromogranin-A (CHGA)	OTXYX5JH	CMGA_HUMAN	Decreases Expression	[8]
Creatine kinase B-type (CKB)	OTUCKOTT	KCRB_HUMAN	Increases Expression	[8]
Cathepsin E (CTSE)	OT4905MD	CATE_HUMAN	Increases Expression	[8]
Carboxypeptidase M (CPM)	OTSI8BE6	CBPM_HUMAN	Decreases Expression	[8]
Prostatic acid phosphatase (ACP3)	OTSIM0YG	PPAP_HUMAN	Decreases Expression	[8]
High mobility group protein HMG-I/HMG-Y (HMGA1)	OTQUSHPX	HMGA1_HUMAN	Decreases Expression	[8]
Glutathione peroxidase 2 (GPX2)	OTXI2NTI	GPX2_HUMAN	Decreases Expression	[8]
Regulator of chromosome condensation (RCC1)	OT25AGMB	RCC1_HUMAN	Decreases Expression	[8]
Amine oxidase A (MAOA)	OT8NIWMQ	AOFA_HUMAN	Increases Expression	[8]
Cannabinoid receptor 1 (CNR1)	OTEALO6G	CNR1_HUMAN	Increases Expression	[8]
Prostaglandin G/H synthase 1 (PTGS1)	OTHCRLEC	PGH1_HUMAN	Increases Expression	[8]
Stromelysin-3 (MMP11)	OTRTXDBM	MMP11_HUMAN	Decreases Expression	[8]
Amine oxidase B (MAOB)	OTTDFM1O	AOFB_HUMAN	Increases Expression	[8]
Dipeptidyl peptidase 4 (DPP4)	OT16MVL9	DPP4_HUMAN	Increases Expression	[8]
Protein S100-A2 (S100A2)	OTTGHJ1H	S10A2_HUMAN	Increases Expression	[8]
Proprotein convertase subtilisin/kexin type 6 (PCSK6)	OTI64BU4	PCSK6_HUMAN	Increases Expression	[8]
Myristoylated alanine-rich C-kinase substrate (MARCKS)	OT7N056G	MARCS_HUMAN	Decreases Expression	[8]
Long-chain-fatty-acid--CoA ligase 1 (ACSL1)	OTB06ESI	ACSL1_HUMAN	Increases Expression	[8]
Gap junction alpha-4 protein (GJA4)	OTUPCT1V	CXA4_HUMAN	Decreases Expression	[8]
Small proline-rich protein 2B (SPRR2B)	OTQ9WPKY	SPR2B_HUMAN	Decreases Expression	[8]
Transcription factor SOX-11 (SOX11)	OT4LG7LA	SOX11_HUMAN	Decreases Expression	[8]
Interleukin-15 (IL15)	OTQSYWQS	IL15_HUMAN	Increases Expression	[8]
Regulator of G-protein signaling 2 (RGS2)	OT0FSRW7	RGS2_HUMAN	Increases Expression	[8]
B1 bradykinin receptor (BDKRB1)	OT1DHSVQ	BKRB1_HUMAN	Decreases Expression	[8]
Large ribosomal subunit protein uL15 (RPL27A)	OTQQHPL0	RL27A_HUMAN	Decreases Expression	[8]
Neuronal pentraxin-2 (NPTX2)	OT3SSJDP	NPTX2_HUMAN	Increases Expression	[8]
Transcription factor SOX-9 (SOX9)	OTVDJFGN	SOX9_HUMAN	Decreases Expression	[8]
Sulfate transporter (SLC26A2)	OTJNHNTO	S26A2_HUMAN	Increases Expression	[8]
cAMP-dependent protein kinase catalytic subunit PRKX (PRKX)	OTDAC6Z0	PRKX_HUMAN	Increases Expression	[8]
Dual specificity mitogen-activated protein kinase kinase 6 (MAP2K6)	OTK13JKC	MP2K6_HUMAN	Increases Expression	[8]
Ephrin-B2 (EFNB2)	OT0DCUOM	EFNB2_HUMAN	Decreases Expression	[8]
Stanniocalcin-1 (STC1)	OTGVVXYF	STC1_HUMAN	Decreases Expression	[8]
MAP3K7 C-terminal-like protein (MAP3K7CL)	OT9J7RLC	M3KCL_HUMAN	Decreases Expression	[8]
Transmembrane protease serine 3 (TMPRSS3)	OT0GTO1Z	TMPS3_HUMAN	Decreases Expression	[8]
Small ribosomal subunit protein uS10 (RPS20)	OTI8052R	RS20_HUMAN	Decreases Expression	[8]
Somatostatin (SST)	OTY75GQH	SMS_HUMAN	Decreases Expression	[8]
Heart- and neural crest derivatives-expressed protein 2 (HAND2)	OTCXYW4Y	HAND2_HUMAN	Increases Expression	[8]
Hemoglobin subunit beta (HBB)	OT514IKQ	HBB_HUMAN	Increases Expression	[8]
Hemoglobin subunit alpha (HBA1)	OTW2BQF4	HBA_HUMAN	Increases Expression	[8]
Iroquois-class homeodomain protein IRX-4 (IRX4)	OT0TV6WK	IRX4_HUMAN	Increases Expression	[8]
Sushi repeat-containing protein SRPX (SRPX)	OT5B9LXS	SRPX_HUMAN	Increases Expression	[8]
Fibulin-2 (FBLN2)	OTEHR7N7	FBLN2_HUMAN	Increases Expression	[8]
Norrin (NDP)	OTGDJ4US	NDP_HUMAN	Increases Expression	[8]
Interleukin-1 receptor-like 1 (IL1RL1)	OTJ6MW31	ILRL1_HUMAN	Increases Expression	[8]
N-acylethanolamine-hydrolyzing acid amidase (NAAA)	OTS2PQ0O	NAAA_HUMAN	Increases Expression	[8]
Transcription factor SOX-4 (SOX4)	OTSS40SS	SOX4_HUMAN	Decreases Expression	[8]
Glutamyl aminopeptidase (ENPEP)	OTCA5C2A	AMPE_HUMAN	Increases Expression	[8]
Interleukin-24 (IL24)	OT4VUWH1	IL24_HUMAN	Decreases Expression	[8]
Uracil nucleotide/cysteinyl leukotriene receptor (GPR17)	OT02OX35	GPR17_HUMAN	Decreases Expression	[8]
Urea transporter 1 (SLC14A1)	OTH7UUV0	UT1_HUMAN	Decreases Expression	[8]
Mesothelin (MSLN)	OTT23UM3	MSLN_HUMAN	Increases Expression	[8]
Peptidyl-prolyl cis-trans isomerase FKBP5 (FKBP5)	OT404F9K	FKBP5_HUMAN	Increases Expression	[8]
SPARC-like protein 1 (SPARCL1)	OT74DWMV	SPRL1_HUMAN	Increases Expression	[8]
Latent-transforming growth factor beta-binding protein 1 (LTBP1)	OTR7Q75L	LTBP1_HUMAN	Increases Expression	[8]
Killer cell immunoglobulin-like receptor 2DS1 (KIR2DS1)	OTRPOQGK	KI2S1_HUMAN	Increases Expression	[8]
P2Y purinoceptor 14 (P2RY14)	OTDGZKED	P2Y14_HUMAN	Increases Expression	[8]
ATP-sensitive inward rectifier potassium channel 8 (KCNJ8)	OTZ8G8FE	KCNJ8_HUMAN	Increases Expression	[8]
Protein GREB1 (GREB1)	OTU6ZA26	GREB1_HUMAN	Increases Expression	[8]
Glycine N-acyltransferase (GLYAT)	OT3WWYXD	GLYAT_HUMAN	Increases Expression	[8]
MTOR-associated protein MEAK7 (MEAK7)	OT9A8JSO	MEAK7_HUMAN	Increases Expression	[8]
ATPase family AAA domain-containing protein 2 (ATAD2)	OT8MCRNY	ATAD2_HUMAN	Increases Expression	[8]
PTB-containing, cubilin and LRP1-interacting protein (PID1)	OT5YJ7FI	PCLI1_HUMAN	Increases Expression	[8]
Adiponectin receptor protein 2 (ADIPOR2)	OT2HDTL8	PAQR2_HUMAN	Increases Expression	[8]
Four-jointed box protein 1 (FJX1)	OT8SVTSS	FJX1_HUMAN	Decreases Expression	[8]
Neuroligin-4, X-linked (NLGN4X)	OTDJGBK8	NLGNX_HUMAN	Increases Expression	[8]
Metallothionein-1M (MT1M)	OTVT8PLU	MT1M_HUMAN	Increases Expression	[8]
Protein cornichon homolog 3 (CNIH3)	OTNLZ2QS	CNIH3_HUMAN	Decreases Expression	[8]
Cholinephosphotransferase 1 (CHPT1)	OT4FJ0K3	CHPT1_HUMAN	Increases Expression	[8]
Secreted and transmembrane protein 1 (SECTM1)	OT5500CF	SCTM1_HUMAN	Increases Expression	[8]
Transmembrane protein 158 (TMEM158)	OT0KUBBI	TM158_HUMAN	Decreases Expression	[8]
Aquaporin-3 (AQP3)	OT2J7JPD	AQP3_HUMAN	Decreases Expression	[8]
Tribbles homolog 2 (TRIB2)	OTHSX3MX	TRIB2_HUMAN	Decreases Expression	[8]
Type II iodothyronine deiodinase (DIO2)	OTGPNSLH	IOD2_HUMAN	Decreases Expression	[8]
TSC22 domain family protein 3 (TSC22D3)	OT03UM03	T22D3_HUMAN	Increases Expression	[8]
Fermitin family homolog 1 (FERMT1)	OT626PBA	FERM1_HUMAN	Decreases Expression	[8]
Keratin, type I cytoskeletal 23 (KRT23)	OTQW6UAG	K1C23_HUMAN	Decreases Expression	[8]
Cysteine-rich secretory protein LCCL domain-containing 2 (CRISPLD2)	OTVSFHTL	CRLD2_HUMAN	Increases Expression	[8]
Regulator of cell cycle RGCC (RGCC)	OTYJMLWM	RGCC_HUMAN	Increases Expression	[8]
Carbohydrate sulfotransferase 7 (CHST7)	OT9HCUST	CHST7_HUMAN	Increases Expression	[8]
Fas apoptotic inhibitory molecule 1 (FAIM)	OTR67PGU	FAIM1_HUMAN	Increases Expression	[8]
Dapper homolog 1 (DACT1)	OT19Z704	DACT1_HUMAN	Decreases Expression	[8]
Pleckstrin-2 (PLEK2)	OTUBWUUK	PLEK2_HUMAN	Decreases Expression	[8]
LIM and cysteine-rich domains protein 1 (LMCD1)	OT3AWE8O	LMCD1_HUMAN	Increases Expression	[8]
Peroxisome proliferator-activated receptor gamma coactivator 1-alpha (PPARGC1A)	OTHCDQ22	PRGC1_HUMAN	Increases Expression	[8]
Lysophosphatidic acid receptor 3 (LPAR3)	OTYOFT3K	LPAR3_HUMAN	Increases Expression	[8]
5'-AMP-activated protein kinase subunit gamma-2 (PRKAG2)	OTHTAM54	AAKG2_HUMAN	Increases Expression	[8]
Interleukin-20 receptor subunit alpha (IL20RA)	OTSIVBVS	I20RA_HUMAN	Increases Expression	[8]
Large neutral amino acids transporter small subunit 2 (SLC7A8)	OT8XXVO8	LAT2_HUMAN	Increases Expression	[8]
Protein FAM153A (FAM153A)	OTNHG4S2	F153A_HUMAN	Decreases Expression	[8]
Potassium voltage-gated channel subfamily G member 1 (KCNG1)	OTZ9ZRG8	KCNG1_HUMAN	Increases Expression	[8]
Cdc42 effector protein 3 (CDC42EP3)	OTUZ3U9Z	BORG2_HUMAN	Increases Expression	[8]
A disintegrin and metalloproteinase with thrombospondin motifs 8 (ADAMTS8)	OT2KFY1S	ATS8_HUMAN	Increases Expression	[8]
Thrombospondin type-1 domain-containing protein 7A (THSD7A)	OT7249HH	THS7A_HUMAN	Increases Expression	[8]
Interleukin-1 receptor-associated kinase 3 (IRAK3)	OTRTLVBG	IRAK3_HUMAN	Increases Expression	[8]
Calpain-6 (CAPN6)	OT8K5PR5	CAN6_HUMAN	Increases Expression	[8]
Unconventional myosin-XVI (MYO16)	OTMS3D8W	MYO16_HUMAN	Increases Expression	[8]
11-beta-hydroxysteroid dehydrogenase type 2 (HSD11B2)	OTHF4H9U	DHI2_HUMAN	Decreases Expression	[58]
Alternative prion protein (PRNP)	OTE85L1Q	APRIO_HUMAN	Increases Expression	[9]
Interferon-related developmental regulator 1 (IFRD1)	OT4SQMLQ	IFRD1_HUMAN	Increases Expression	[9]
Myc box-dependent-interacting protein 1 (BIN1)	OTK8O0X8	BIN1_HUMAN	Increases Expression	[9]
Nucleolar protein 56 (NOP56)	OTT67SRZ	NOP56_HUMAN	Decreases Expression	[9]
Claudin-4 (CLDN4)	OT9C4PZ4	CLD4_HUMAN	Decreases Expression	[9]
Class E basic helix-loop-helix protein 40 (BHLHE40)	OTITX14U	BHE40_HUMAN	Increases Expression	[9]
Integrin beta-1-binding protein 1 (ITGB1BP1)	OTVQFNGS	ITBP1_HUMAN	Decreases Expression	[9]
Na(+)/H(+) exchange regulatory cofactor NHE-RF1 (NHERF1)	OTFK8KDP	NHRF1_HUMAN	Decreases Expression	[9]
Tax1-binding protein 3 (TAX1BP3)	OTQ6IB4T	TX1B3_HUMAN	Decreases Expression	[9]
BET1 homolog (BET1)	OTGX2557	BET1_HUMAN	Increases Expression	[9]
Period circadian protein homolog 1 (PER1)	OTVQF3WX	PER1_HUMAN	Increases Expression	[9]
ATP-dependent RNA helicase DHX15 (DHX15)	OT4F98TK	DHX15_HUMAN	Decreases Expression	[9]
Arf-GAP with SH3 domain, ANK repeat and PH domain-containing protein 2 (ASAP2)	OTGEXULW	ASAP2_HUMAN	Increases Expression	[9]
Signal-induced proliferation-associated 1-like protein 1 (SIPA1L1)	OTS6M0KO	SI1L1_HUMAN	Increases Expression	[9]
U3 small nucleolar RNA-interacting protein 2 (RRP9)	OT97EAV4	U3IP2_HUMAN	Decreases Expression	[9]
A-kinase anchor protein 8 (AKAP8)	OTK3EQAI	AKAP8_HUMAN	Decreases Expression	[9]
Heparan-sulfate 6-O-sulfotransferase 1 (HS6ST1)	OTABV7D2	H6ST1_HUMAN	Decreases Expression	[9]
Protein diaphanous homolog 1 (DIAPH1)	OTZBYPLH	DIAP1_HUMAN	Decreases Expression	[9]
Beta-1,4-galactosyltransferase 2 (B4GALT2)	OTYIQT2F	B4GT2_HUMAN	Decreases Expression	[9]
Slit homolog 1 protein (SLIT1)	OT35RBNT	SLIT1_HUMAN	Decreases Expression	[9]
Lysine-specific demethylase 4A (KDM4A)	OTDN3EGK	KDM4A_HUMAN	Increases Expression	[9]
Pre-mRNA-processing factor 40 homolog A (PRPF40A)	OT6EXJZN	PR40A_HUMAN	Increases Expression	[9]
Geminin (GMNN)	OTDYKNIY	GEMI_HUMAN	Decreases Expression	[9]
Protein phosphatase 1 regulatory subunit 15A (PPP1R15A)	OTYG179K	PR15A_HUMAN	Increases Expression	[9]
Fibroblast growth factor 18 (FGF18)	OTO7KJF8	FGF18_HUMAN	Decreases Expression	[9]
Glutamine--fructose-6-phosphate aminotransferase 2 (GFPT2)	OTYKP5G0	GFPT2_HUMAN	Increases Expression	[9]
Chondroitin sulfate proteoglycan 5 (CSPG5)	OTXFEBWR	CSPG5_HUMAN	Decreases Expression	[9]
Transforming acidic coiled-coil-containing protein 2 (TACC2)	OTW4M7HI	TACC2_HUMAN	Increases Expression	[9]
Tripartite motif-containing protein 16 (TRIM16)	OTLRXYOZ	TRI16_HUMAN	Decreases Expression	[9]
Phosphoacetylglucosamine mutase (PGM3)	OTHS1ZSP	AGM1_HUMAN	Increases Expression	[9]
BAG family molecular chaperone regulator 3 (BAG3)	OTVXYUDQ	BAG3_HUMAN	Increases Expression	[9]
L-lactate dehydrogenase A chain (LDHA)	OTN7K4XB	LDHA_HUMAN	Decreases Expression	[9]
Low-density lipoprotein receptor (LDLR)	OTH559LU	LDLR_HUMAN	Increases Expression	[9]
Metallothionein-2 (MT2A)	OTHOACHD	MT2_HUMAN	Increases Expression	[9]
Estrogen receptor (ESR1)	OTKLU61J	ESR1_HUMAN	Decreases Expression	[9]
Metallothionein-1A (MT1A)	OTKBH52X	MT1A_HUMAN	Increases Expression	[9]
Metallothionein-1E (MT1E)	OTXJKU4Y	MT1E_HUMAN	Increases Expression	[9]
Sodium/potassium-transporting ATPase subunit alpha-1 (ATP1A1)	OTCJ458Q	AT1A1_HUMAN	Increases Expression	[9]
Metallothionein-1B (MT1B)	OTUA4FFH	MT1B_HUMAN	Increases Expression	[9]
Fumarate hydratase, mitochondrial (FH)	OTEQWU6Q	FUMH_HUMAN	Decreases Expression	[9]
Thrombospondin-1 (THBS1)	OT0ECWK3	TSP1_HUMAN	Decreases Expression	[9]
Asparagine synthetase (ASNS)	OT8R922G	ASNS_HUMAN	Increases Expression	[9]
Tropomyosin alpha-1 chain (TPM1)	OTD73X6R	TPM1_HUMAN	Decreases Expression	[9]
Heat shock 70 kDa protein 1A (HSPA1A)	OTKGIE76	HS71A_HUMAN	Increases Expression	[9]
Ornithine decarboxylase (ODC1)	OTNDAGRR	DCOR_HUMAN	Decreases Expression	[9]
Alpha-actinin-1 (ACTN1)	OTUCLNXH	ACTN1_HUMAN	Decreases Expression	[9]
Metallothionein-1G (MT1G)	OTAV1OCR	MT1G_HUMAN	Increases Expression	[9]
Bifunctional methylenetetrahydrofolate dehydrogenase/cyclohydrolase, mitochondrial (MTHFD2)	OT1LQSGX	MTDC_HUMAN	Increases Expression	[9]
G2/mitotic-specific cyclin-B1 (CCNB1)	OT19S7E5	CCNB1_HUMAN	Decreases Expression	[9]
Aspartate aminotransferase, cytoplasmic (GOT1)	OTZLM5UB	AATC_HUMAN	Increases Expression	[9]
Transcription factor JunD (JUND)	OTNKACJD	JUND_HUMAN	Increases Expression	[9]
Syndecan-1 (SDC1)	OTWKRVZC	SDC1_HUMAN	Decreases Expression	[9]
Cyclic AMP-dependent transcription factor ATF-4 (ATF4)	OTRFV19J	ATF4_HUMAN	Increases Expression	[9]
Retinoic acid receptor RXR-alpha (RXRA)	OTP1TBDM	RXRA_HUMAN	Decreases Expression	[9]
Ephrin-A1 (EFNA1)	OTU2NUA2	EFNA1_HUMAN	Increases Expression	[9]
Nuclear receptor subfamily 4immunitygroup A member 1 (NR4A1)	OTGP6GA4	NR4A1_HUMAN	Increases Expression	[9]
Splicing factor, proline- and glutamine-rich (SFPQ)	OTLCIAPJ	SFPQ_HUMAN	Decreases Expression	[9]
Growth arrest and DNA damage-inducible protein GADD45 alpha (GADD45A)	OTDRV63V	GA45A_HUMAN	Increases Expression	[9]
Myosin regulatory light polypeptide 9 (MYL9)	OT6B22JB	MYL9_HUMAN	Decreases Expression	[9]
DnaJ homolog subfamily B member 1 (DNAJB1)	OTCOSEVH	DNJB1_HUMAN	Increases Expression	[9]
NF-kappa-B inhibitor alpha (NFKBIA)	OTFT924M	IKBA_HUMAN	Increases Expression	[9]
DNA repair nuclease/redox regulator APEX1 (APEX1)	OT53OI14	APEX1_HUMAN	Decreases Expression	[9]
Peptidyl-prolyl cis-trans isomerase F, mitochondrial (PPIF)	OTRA8ZVE	PPIF_HUMAN	Decreases Expression	[9]
Aldehyde dehydrogenase, dimeric NADP-preferring (ALDH3A1)	OTAYZZE6	AL3A1_HUMAN	Decreases Expression	[9]
S-adenosylmethionine synthase isoform type-2 (MAT2A)	OTFJMIQR	METK2_HUMAN	Decreases Expression	[9]
Homeobox protein Hox-A10 (HOXA10)	OTB6GQ09	HXA10_HUMAN	Decreases Expression	[9]
DNA damage-inducible transcript 3 protein (DDIT3)	OTI8YKKE	DDIT3_HUMAN	Increases Expression	[9]
ADP-ribosylation factor-like protein 4A (ARL4A)	OTAH2GFA	ARL4A_HUMAN	Increases Expression	[9]
DNA-binding protein inhibitor ID-1 (ID1)	OTKGNZN5	ID1_HUMAN	Increases Expression	[9]
Tyrosine-protein kinase CSK (CSK)	OTP03OD0	CSK_HUMAN	Decreases Expression	[9]
Glycine--tRNA ligase (GARS1)	OT5B6R9Y	GARS_HUMAN	Increases Expression	[9]
Serine--tRNA ligase, cytoplasmic (SARS1)	OTFKXQ1O	SYSC_HUMAN	Increases Expression	[9]
CCAAT/enhancer-binding protein delta (CEBPD)	OTNBIPMY	CEBPD_HUMAN	Increases Expression	[9]
CCAAT/enhancer-binding protein gamma (CEBPG)	OTGNAX3H	CEBPG_HUMAN	Increases Expression	[9]
Eukaryotic translation initiation factor 5 (EIF5)	OT79PQUN	IF5_HUMAN	Increases Expression	[9]
Apolipoprotein C-IV (APOC4)	OTE8ZUXY	APOC4_HUMAN	Decreases Expression	[9]
Mesencephalic astrocyte-derived neurotrophic factor (MANF)	OT2AH8VJ	MANF_HUMAN	Increases Expression	[9]
BH3-interacting domain death agonist (BID)	OTOSHSHU	BID_HUMAN	Decreases Expression	[9]
Methionine--tRNA ligase, cytoplasmic (MARS1)	OTLJ6MHJ	SYMC_HUMAN	Increases Expression	[9]
Sestrin-2 (SESN2)	OT889IXY	SESN2_HUMAN	Increases Expression	[9]
LIM domain transcription factor LMO4 (LMO4)	OT5NDCT9	LMO4_HUMAN	Increases Expression	[9]
Actin, aortic smooth muscle (ACTA2)	OTEDLG8E	ACTA_HUMAN	Decreases Expression	[9]
GTP-binding nuclear protein Ran (RAN)	OT2TER5M	RAN_HUMAN	Decreases Expression	[9]
Metallothionein-1H (MT1H)	OT0MVBM6	MT1H_HUMAN	Increases Expression	[9]
Metallothionein-1X (MT1X)	OT9AKFVS	MT1X_HUMAN	Increases Expression	[9]
Small ribosomal subunit protein bS6m (MRPS6)	OTKFY73U	RT06_HUMAN	Increases Expression	[9]
CD83 antigen (CD83)	OT1V4WQF	CD83_HUMAN	Decreases Expression	[9]
Large neutral amino acids transporter small subunit 1 (SLC7A5)	OT2WPVXD	LAT1_HUMAN	Decreases Expression	[9]
Transgelin (TAGLN)	OTAEZ0KP	TAGL_HUMAN	Decreases Expression	[9]
DNA-binding protein inhibitor ID-2 (ID2)	OT0U1D53	ID2_HUMAN	Increases Expression	[9]
DNA-binding protein inhibitor ID-3 (ID3)	OTUULW5Z	ID3_HUMAN	Increases Expression	[9]
Keratin, type I cytoskeletal 17 (KRT17)	OT6Y1DPK	K1C17_HUMAN	Decreases Expression	[9]
Sex-determining region Y protein (SRY)	OT516T6D	SRY_HUMAN	Increases Expression	[9]
Complement component 1 Q subcomponent-binding protein, mitochondrial (C1QBP)	OTPYQX3K	C1QBP_HUMAN	Decreases Expression	[9]
Hyaluronidase-2 (HYAL2)	OTTVINXW	HYAL2_HUMAN	Decreases Expression	[9]
Krueppel-like factor 10 (KLF10)	OT4F4UGS	KLF10_HUMAN	Decreases Expression	[9]
TAR DNA-binding protein 43 (TARDBP)	OTVOSFWW	TADBP_HUMAN	Decreases Expression	[9]
Serine/arginine-rich splicing factor 6 (SRSF6)	OTGLOSYE	SRSF6_HUMAN	Decreases Expression	[9]
Syntaxin-3 (STX3)	OT4CIWLJ	STX3_HUMAN	Increases Expression	[9]
Sequestosome-1 (SQSTM1)	OTGY5D5J	SQSTM_HUMAN	Increases Expression	[9]
Histone deacetylase 1 (HDAC1)	OTQDNOXZ	HDAC1_HUMAN	Decreases Expression	[9]
Trophoblast glycoprotein (TPBG)	OTU2OTLL	TPBG_HUMAN	Increases Expression	[9]
Integrin alpha-7 (ITGA7)	OTTBTAYW	ITA7_HUMAN	Increases Expression	[9]
Nuclear receptor coactivator 4 (NCOA4)	OTRVU0UA	NCOA4_HUMAN	Decreases Expression	[9]
Krueppel-like factor 5 (KLF5)	OT1ABI9N	KLF5_HUMAN	Increases Expression	[9]
Coactosin-like protein (COTL1)	OT6YCNLF	COTL1_HUMAN	Decreases Expression	[9]
Tubulin--tyrosine ligase-like protein 12 (TTLL12)	OTJQ8RF4	TTL12_HUMAN	Decreases Expression	[9]
Fibroblast growth factor-binding protein 1 (FGFBP1)	OTP4BSCH	FGFP1_HUMAN	Decreases Expression	[9]
Homocysteine-responsive endoplasmic reticulum-resident ubiquitin-like domain member 1 protein (HERPUD1)	OT9EROL6	HERP1_HUMAN	Increases Expression	[9]
Ribosome biogenesis regulatory protein homolog (RRS1)	OTTNCZN6	RRS1_HUMAN	Decreases Expression	[9]
Plectin (PLEC)	OTU4XDEG	PLEC_HUMAN	Decreases Expression	[9]
Homeobox protein TGIF1 (TGIF1)	OTN9VHAG	TGIF1_HUMAN	Increases Expression	[9]
Dual specificity protein phosphatase 5 (DUSP5)	OTH96RA7	DUS5_HUMAN	Increases Expression	[9]
Centrosomal protein kizuna (KIZ)	OT5VCKSM	KIZ_HUMAN	Increases Expression	[9]
Pleckstrin homology-like domain family A member 2 (PHLDA2)	OTMV9DPP	PHLA2_HUMAN	Increases Expression	[9]
Immediate early response gene 5-like protein (IER5L)	OT6IG629	IER5L_HUMAN	Increases Expression	[9]
Rho-related GTP-binding protein RhoU (RHOU)	OTERIAD4	RHOU_HUMAN	Increases Expression	[9]
TBC1 domain family member 1 (TBC1D1)	OTI9V7B0	TBCD1_HUMAN	Increases Expression	[9]
E3 ubiquitin-protein ligase synoviolin (SYVN1)	OTZ4ZJP5	SYVN1_HUMAN	Increases Expression	[9]
F-box only protein 11 (FBXO11)	OTGWF3Q2	FBX11_HUMAN	Increases Expression	[9]
Prostaglandin reductase 2 (PTGR2)	OTYPYOUM	PTGR2_HUMAN	Increases Expression	[9]
Solute carrier family 4 member 11 (SLC4A11)	OTMMNQ2E	S4A11_HUMAN	Decreases Expression	[9]
sn-1-specific diacylglycerol lipase ABHD11 (ABHD11)	OTJE9UZY	ABHDB_HUMAN	Decreases Expression	[9]
Ribosome biogenesis protein BRX1 homolog (BRIX1)	OTQ5F1D1	BRX1_HUMAN	Decreases Expression	[9]
RB1-inducible coiled-coil protein 1 (RB1CC1)	OTZK8PFX	RBCC1_HUMAN	Increases Expression	[9]
Importin-4 (IPO4)	OT2N5020	IPO4_HUMAN	Decreases Expression	[9]
Gem-associated protein 6 (GEMIN6)	OTE262KF	GEMI6_HUMAN	Decreases Expression	[9]
Paraspeckle component 1 (PSPC1)	OTYS6WQ8	PSPC1_HUMAN	Decreases Expression	[9]
Nanos homolog 1 (NANOS1)	OT3UNZZY	NANO1_HUMAN	Decreases Expression	[9]
Jun dimerization protein 2 (JDP2)	OTW35WKX	JDP2_HUMAN	Increases Expression	[9]
SEC14-like protein 1 (SEC14L1)	OTA75FET	S14L1_HUMAN	Increases Expression	[9]
Serine/threonine-protein phosphatase 2A regulatory subunit B'' subunit gamma (PPP2R3C)	OT7E6V9B	P2R3C_HUMAN	Decreases Expression	[9]
Nucleoporin SEH1 (SEH1L)	OTHW13AE	SEH1_HUMAN	Decreases Expression	[9]
tRNA-dihydrouridine(47) synthase -like (DUS3L)	OTNY343A	DUS3L_HUMAN	Decreases Expression	[9]
Arf-GAP with GTPase, ANK repeat and PH domain-containing protein 3 (AGAP3)	OT8C6PKL	AGAP3_HUMAN	Decreases Expression	[9]
Sodium-coupled neutral amino acid symporter 2 (SLC38A2)	OTALABSK	S38A2_HUMAN	Increases Expression	[9]
Erbin (ERBIN)	OTNWTUA8	ERBIN_HUMAN	Increases Expression	[9]
Tribbles homolog 3 (TRIB3)	OTG5OS7X	TRIB3_HUMAN	Increases Expression	[9]
Noelin (OLFM1)	OTOYPEWW	NOE1_HUMAN	Decreases Expression	[9]
BAG family molecular chaperone regulator 1 (BAG1)	OTRQNIA4	BAG1_HUMAN	Decreases Expression	[9]
Retinoic acid receptor responder protein 2 (RARRES2)	OT1BJE8K	RARR2_HUMAN	Decreases Expression	[9]
Growth/differentiation factor 15 (GDF15)	OTWQN50N	GDF15_HUMAN	Increases Expression	[9]
Glutamate-rich WD repeat-containing protein 1 (GRWD1)	OT6M13ZV	GRWD1_HUMAN	Decreases Expression	[9]
Transmembrane protein 47 (TMEM47)	OTAJ4CPX	TMM47_HUMAN	Increases Expression	[9]
Glutathione-specific gamma-glutamylcyclotransferase 1 (CHAC1)	OTJGE772	CHAC1_HUMAN	Increases Expression	[9]
Very long chain fatty acid elongase 1 (ELOVL1)	OTIDTQ8R	ELOV1_HUMAN	Decreases Expression	[9]
Cyclin-dependent kinase 19 (CDK19)	OTVMM0CP	CDK19_HUMAN	Increases Expression	[9]
TBC1 domain family member 2A (TBC1D2)	OTSGHPD0	TBD2A_HUMAN	Decreases Expression	[9]
Zinc finger protein GLIS2 (GLIS2)	OTOUUV1X	GLIS2_HUMAN	Decreases Expression	[9]
Protein sprouty homolog 4 (SPRY4)	OT2VK9N0	SPY4_HUMAN	Increases Expression	[9]
Protein rogdi homolog (ROGDI)	OTZ7LSKJ	ROGDI_HUMAN	Decreases Expression	[9]
Cysteine/serine-rich nuclear protein 2 (CSRNP2)	OTRZNC1C	CSRN2_HUMAN	Increases Expression	[9]
Opsin-3 (OPN3)	OTON6BFU	OPN3_HUMAN	Increases Expression	[9]
Phosducin-like protein 3 (PDCL3)	OTD3WGV1	PDCL3_HUMAN	Decreases Expression	[9]
GDP-fucose protein O-fucosyltransferase 1 (POFUT1)	OTOBJZIT	OFUT1_HUMAN	Decreases Expression	[9]
EH domain-containing protein 1 (EHD1)	OTDMEKLV	EHD1_HUMAN	Decreases Expression	[9]
DNA-directed RNA polymerase I subunit RPA2 (POLR1B)	OTKREU8M	RPA2_HUMAN	Decreases Expression	[9]
GrpE protein homolog 1, mitochondrial (GRPEL1)	OT8O00YJ	GRPE1_HUMAN	Decreases Expression	[9]
POZ-, AT hook-, and zinc finger-containing protein 1 (PATZ1)	OT0X9WGR	PATZ1_HUMAN	Decreases Expression	[9]
MAP kinase-interacting serine/threonine-protein kinase 2 (MKNK2)	OTNA9G8V	MKNK2_HUMAN	Increases Expression	[9]
Stromal cell-derived factor 2-like protein 1 (SDF2L1)	OTE7JIO2	SDF2L_HUMAN	Increases Expression	[9]
Fructose-2,6-bisphosphatase TIGAR (TIGAR)	OTR7NMRJ	TIGAR_HUMAN	Decreases Expression	[9]
DNA polymerase epsilon subunit 4 (POLE4)	OTCMWUT6	DPOE4_HUMAN	Decreases Expression	[9]
Dual specificity protein phosphatase 22 (DUSP22)	OTEZ3U85	DUS22_HUMAN	Increases Expression	[9]
p21-activated protein kinase-interacting protein 1 (PAK1IP1)	OT21CROX	PK1IP_HUMAN	Decreases Expression	[9]
DNA damage-inducible transcript 4 protein (DDIT4)	OTHY8SY4	DDIT4_HUMAN	Increases Expression	[9]
H/ACA ribonucleoprotein complex subunit 1 (GAR1)	OTA580RX	GAR1_HUMAN	Decreases Expression	[9]
Protocadherin Fat 2 (FAT2)	OTRGT3E8	FAT2_HUMAN	Decreases Expression	[9]
Myoferlin (MYOF)	OTRFC3IJ	MYOF_HUMAN	Decreases Expression	[9]
]-phosphatase 1, mitochondrial (PDP1)	OT82RTMT	PDP1_HUMAN	Decreases Expression	[9]
Large ribosomal subunit protein bL27m (MRPL27)	OT27BQQ6	RM27_HUMAN	Decreases Expression	[9]
SH3 domain-binding protein 4 (SH3BP4)	OTVIRKW7	SH3B4_HUMAN	Decreases Expression	[9]
DnaJ homolog subfamily B member 9 (DNAJB9)	OT38EQT6	DNJB9_HUMAN	Increases Expression	[9]
LIM domain and actin-binding protein 1 (LIMA1)	OTONPC9R	LIMA1_HUMAN	Decreases Expression	[9]
Cysteine and histidine-rich domain-containing protein 1 (CHORDC1)	OT3W6F1U	CHRD1_HUMAN	Increases Expression	[9]
General transcription factor II-I repeat domain-containing protein 1 (GTF2IRD1)	OTEG9KU1	GT2D1_HUMAN	Increases Expression	[9]
mRNA turnover protein 4 homolog (MRTO4)	OTZ4C6FH	MRT4_HUMAN	Decreases Expression	[9]
Cystine/glutamate transporter (SLC7A11)	OTKJ6PXW	XCT_HUMAN	Increases Expression	[9]
Fibronectin type-III domain-containing protein 3A (FNDC3A)	OTUX3S2I	FND3A_HUMAN	Increases Expression	[9]
Small ribosomal subunit protein bS1m (MRPS28)	OT8CLJ6M	RT28_HUMAN	Decreases Expression	[9]
DNA-directed RNA polymerase III subunit RPC10 (POLR3K)	OTZCSF6A	RPC10_HUMAN	Decreases Expression	[9]
Hypoxia up-regulated protein 1 (HYOU1)	OTBGBSOV	HYOU1_HUMAN	Increases Expression	[9]
Phosphoserine aminotransferase (PSAT1)	OTVV1YV9	SERC_HUMAN	Increases Expression	[9]
KAT8 regulatory NSL complex subunit 1-like protein (KANSL1L)	OTOAH2RR	KAL1L_HUMAN	Increases Expression	[10]
Serine/threonine-protein kinase Sgk1 (SGK1)	OT301T1U	SGK1_HUMAN	Increases Expression	[10]
PDZ and LIM domain protein 1 (PDLIM1)	OT4EGCPG	PDLI1_HUMAN	Decreases Expression	[10]
Galectin-8 (LGALS8)	OT71LJ8T	LEG8_HUMAN	Increases Expression	[10]
Stearoyl-CoA desaturase (SCD)	OTB1073G	SCD_HUMAN	Increases Expression	[10]
Homeobox protein cut-like 2 (CUX2)	OTDJTQAJ	CUX2_HUMAN	Decreases Expression	[10]
Potassium channel subfamily K member 3 (KCNK3)	OTWMAV6G	KCNK3_HUMAN	Decreases Expression	[10]
Kinetochore protein NDC80 homolog (NDC80)	OTS7D306	NDC80_HUMAN	Increases Expression	[10]
UDP-N-acetylglucosamine--peptide N-acetylglucosaminyltransferase 110 kDa subunit (OGT)	OT1Z1ZXE	OGT1_HUMAN	Decreases Expression	[10]
Insulin-induced gene 1 protein (INSIG1)	OTZF5X1D	INSI1_HUMAN	Increases Expression	[10]
Cytochrome b5 type B (CYB5B)	OTONNAV1	CYB5B_HUMAN	Increases Expression	[10]
Origin recognition complex subunit 4 (ORC4)	OT3ACTST	ORC4_HUMAN	Increases Expression	[10]
HMG box-containing protein 1 (HBP1)	OTDPGGDV	HBP1_HUMAN	Increases Expression	[10]
Acyl-CoA (FADS1)	OTUYOYHX	FADS1_HUMAN	Increases Expression	[10]
Periplakin (PPL)	OTTM4WDO	PEPL_HUMAN	Increases Expression	[10]
Lathosterol oxidase (SC5D)	OT41KMW4	SC5D_HUMAN	Increases Expression	[10]
Isocitrate dehydrogenase cytoplasmic (IDH1)	OT4DLHC8	IDHC_HUMAN	Increases Expression	[10]
monooxygenase MICAL2 (MICAL2)	OT04OQQJ	MICA2_HUMAN	Decreases Expression	[10]
ATP-binding cassette sub-family C member 6 (ABCC6)	OTZT0LKT	MRP6_HUMAN	Decreases Expression	[10]
Structural maintenance of chromosomes protein 2 (SMC2)	OT5S0DV4	SMC2_HUMAN	Increases Expression	[10]
Acyl-CoA 6-desaturase (FADS2)	OTUX531P	FADS2_HUMAN	Increases Expression	[10]
Cystatin-A (CSTA)	OT1K68KE	CYTA_HUMAN	Decreases Expression	[10]
Pro-neuropeptide Y (NPY)	OT4ICV3P	NPY_HUMAN	Increases Expression	[10]
Hemoglobin subunit delta (HBD)	OTRQG4WA	HBD_HUMAN	Increases Expression	[10]
Collagen alpha-1(I) chain (COL1A1)	OTI31178	CO1A1_HUMAN	Decreases Expression	[10]
Collagen alpha-1(IV) chain (COL4A1)	OTL6D1YE	CO4A1_HUMAN	Decreases Expression	[10]
Fibronectin (FN1)	OTB5ZN4Q	FINC_HUMAN	Decreases Expression	[10]
3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMGCR)	OTRT3F3U	HMDH_HUMAN	Increases Expression	[10]
Collagen alpha-2(V) chain (COL5A2)	OT5VOSQE	CO5A2_HUMAN	Decreases Expression	[10]
Cyclin-dependent kinase 1 (CDK1)	OTW1SC2N	CDK1_HUMAN	Increases Expression	[10]
Insulin-like growth factor 1 receptor (IGF1R)	OTXJIF13	IGF1R_HUMAN	Decreases Expression	[10]
Collagen alpha-2(I) chain (COL1A2)	OTY7G382	CO1A2_HUMAN	Decreases Expression	[10]
72 kDa type IV collagenase (MMP2)	OT5NIWA2	MMP2_HUMAN	Decreases Expression	[10]
Neprilysin (MME)	OT5Q39P8	NEP_HUMAN	Decreases Expression	[10]
Inhibin beta A chain (INHBA)	OTSP64PQ	INHBA_HUMAN	Decreases Expression	[10]
Matrix Gla protein (MGP)	OTZWU3FU	MGP_HUMAN	Decreases Expression	[10]
Heme oxygenase 1 (HMOX1)	OTC1W6UX	HMOX1_HUMAN	Increases Expression	[10]
Neurofilament heavy polypeptide (NEFH)	OTMSCW5I	NFH_HUMAN	Decreases Expression	[10]
Collagen alpha-1(XI) chain (COL11A1)	OTB0DRMS	COBA1_HUMAN	Decreases Expression	[10]
Collagen alpha-1(VI) chain (COL6A1)	OTYKSCOB	CO6A1_HUMAN	Decreases Expression	[10]
Parathyroid hormone-related protein (PTHLH)	OTI1JF13	PTHR_HUMAN	Increases Expression	[10]
Myosin-1 (MYH1)	OT8YBDOT	MYH1_HUMAN	Decreases Expression	[10]
Farnesyl pyrophosphate synthase (FDPS)	OT6CKWV5	FPPS_HUMAN	Increases Expression	[10]
Amphiregulin (AREG)	OTJFOR67	AREG_HUMAN	Increases Expression	[10]
Immunoglobulin lambda-like polypeptide 1 (IGLL1)	OTRTNVOG	IGLL1_HUMAN	Decreases Expression	[10]
Platelet endothelial cell adhesion molecule (PECAM1)	OTXOM4D9	PECA1_HUMAN	Decreases Expression	[10]
Desmin (DES)	OTI09KBW	DESM_HUMAN	Decreases Expression	[10]
Insulin-like growth factor-binding protein 3 (IGFBP3)	OTIX63TX	IBP3_HUMAN	Decreases Expression	[10]
Insulin-like growth factor-binding protein 2 (IGFBP2)	OTG1P60E	IBP2_HUMAN	Decreases Expression	[10]
Protein EVI2A (EVI2A)	OTR8RUXQ	EVI2A_HUMAN	Increases Expression	[10]
Brain-derived neurotrophic factor (BDNF)	OTLGH7EW	BDNF_HUMAN	Decreases Expression	[10]
Plasma membrane calcium-transporting ATPase 4 (ATP2B4)	OTMWFDAC	AT2B4_HUMAN	Decreases Expression	[10]
Cytochrome c oxidase subunit 7A1, mitochondrial (COX7A1)	OTHV25GG	CX7A1_HUMAN	Decreases Expression	[10]
G1/S-specific cyclin-D1 (CCND1)	OT8HPTKJ	CCND1_HUMAN	Decreases Expression	[10]
Insulin-like growth factor-binding protein 5 (IGFBP5)	OTRE5V0C	IBP5_HUMAN	Decreases Expression	[10]
Collagen alpha-2(VIII) chain (COL8A2)	OTASWJ69	CO8A2_HUMAN	Decreases Expression	[10]
Neuropeptide Y receptor type 1 (NPY1R)	OT5DA9DY	NPY1R_HUMAN	Increases Expression	[10]
High mobility group protein B2 (HMGB2)	OTGEGAOK	HMGB2_HUMAN	Increases Expression	[10]
Oxytocin receptor (OXTR)	OT7WFW4U	OXYR_HUMAN	Decreases Expression	[10]
Neural cell adhesion molecule L1 (L1CAM)	OTNWAQ4Y	L1CAM_HUMAN	Decreases Expression	[10]
Glycerol kinase (GK)	OTK2YRA0	GLPK_HUMAN	Increases Expression	[10]
Cytochrome P450 2C18 (CYP2C18)	OTY687L9	CP2CI_HUMAN	Decreases Expression	[10]
Serine hydroxymethyltransferase, cytosolic (SHMT1)	OTIINA3J	GLYC_HUMAN	Increases Expression	[10]
Squalene synthase (FDFT1)	OTGDISIT	FDFT_HUMAN	Increases Expression	[10]
Mitogen-activated protein kinase kinase kinase 8 (MAP3K8)	OTOZTA1F	M3K8_HUMAN	Increases Expression	[10]
Cyclin-dependent kinase 4 inhibitor C (CDKN2C)	OTCLOV90	CDN2C_HUMAN	Increases Expression	[10]
C-X-C motif chemokine 5 (CXCL5)	OTZOUPCA	CXCL5_HUMAN	Increases Expression	[10]
Cytosolic phospholipase A2 (PLA2G4A)	OTE70SOT	PA24A_HUMAN	Increases Expression	[10]
Lanosterol synthase (LSS)	OT9W2SFH	LSS_HUMAN	Increases Expression	[10]
Interferon alpha/beta receptor 2 (IFNAR2)	OTBIRNIJ	INAR2_HUMAN	Increases Expression	[10]
Protein PRRC2A (PRRC2A)	OTBX6FM5	PRC2A_HUMAN	Decreases Expression	[10]
Tryptophan 2,3-dioxygenase (TDO2)	OTV5HKJ4	T23O_HUMAN	Increases Expression	[10]
Centromere protein F (CENPF)	OT7AG0SW	CENPF_HUMAN	Increases Expression	[10]
Steroidogenic acute regulatory protein, mitochondrial (STAR)	OTFEZ5AI	STAR_HUMAN	Decreases Expression	[10]
ETS translocation variant 1 (ETV1)	OT6PMJIK	ETV1_HUMAN	Increases Expression	[10]
Methionine aminopeptidase 2 (METAP2)	OTNDI7YK	MAP2_HUMAN	Decreases Expression	[10]
Tumor necrosis factor ligand superfamily member 10 (TNFSF10)	OT4PXBTA	TNF10_HUMAN	Decreases Expression	[10]
Rho GDP-dissociation inhibitor 1 (ARHGDIA)	OTEXWJDO	GDIR1_HUMAN	Decreases Expression	[10]
A disintegrin and metalloproteinase with thrombospondin motifs 20 (ADAMTS20)	OTU0EKLN	ATS20_HUMAN	Increases Expression	[10]
Small ubiquitin-related modifier 1 (SUMO1)	OTJFD4P5	SUMO1_HUMAN	Increases Expression	[10]
N-acetylgalactosamine kinase (GALK2)	OTHR35JF	GALK2_HUMAN	Increases Expression	[10]
Hydroxymethylglutaryl-CoA synthase, cytoplasmic (HMGCS1)	OTCO26FV	HMCS1_HUMAN	Increases Expression	[10]
Dystonin (DST)	OTHZBM4X	DYST_HUMAN	Decreases Expression	[10]
Mevalonate kinase (MVK)	OTHJCUKT	KIME_HUMAN	Increases Expression	[10]
Neurogenic locus notch homolog protein 2 (NOTCH2)	OTQ3Y9PA	NOTC2_HUMAN	Decreases Expression	[10]
Acetylcholine receptor subunit epsilon (CHRNE)	OTGGXGGB	ACHE_HUMAN	Decreases Expression	[10]
3-ketodihydrosphingosine reductase (KDSR)	OTCIES3H	KDSR_HUMAN	Increases Expression	[10]
Collagen alpha-1(XVI) chain (COL16A1)	OTOWKUO2	COGA1_HUMAN	Decreases Expression	[10]
Nuclear pore complex protein Nup160 (NUP160)	OTUKVV3I	NU160_HUMAN	Increases Expression	[10]
Cell division cycle protein 20 homolog (CDC20)	OTCOEZRV	CDC20_HUMAN	Increases Expression	[10]
Transformer-2 protein homolog alpha (TRA2A)	OT5NHOO3	TRA2A_HUMAN	Decreases Expression	[10]
Isopentenyl-diphosphate Delta-isomerase 1 (IDI1)	OTGM06VJ	IDI1_HUMAN	Increases Expression	[10]
Ensconsin (MAP7)	OTVSSJ33	MAP7_HUMAN	Increases Expression	[10]
Phosphatidate phosphatase LPIN1 (LPIN1)	OTQ75KF2	LPIN1_HUMAN	Increases Expression	[10]
3-beta-hydroxysteroid-Delta(8),Delta(7)-isomerase (EBP)	OTSMGKXQ	EBP_HUMAN	Increases Expression	[10]
High mobility group nucleosome-binding domain-containing protein 3 (HMGN3)	OTA2TBWS	HMGN3_HUMAN	Increases Expression	[10]
Sterol-4-alpha-carboxylate 3-dehydrogenase, decarboxylating (NSDHL)	OTK3EJFD	NSDHL_HUMAN	Increases Expression	[10]
Methylsterol monooxygenase 1 (MSMO1)	OTKV62RZ	MSMO1_HUMAN	Increases Expression	[10]
Histone-lysine N-methyltransferase EZH2 (EZH2)	OTIEHTKW	EZH2_HUMAN	Increases Expression	[10]
Protein NKG7 (NKG7)	OTXDD006	NKG7_HUMAN	Increases Expression	[10]
Lanosterol 14-alpha demethylase (CYP51A1)	OTAYHG9C	CP51A_HUMAN	Increases Expression	[10]
Sister chromatid cohesion protein PDS5 homolog A (PDS5A)	OT34P56Z	PDS5A_HUMAN	Increases Expression	[10]
TBC1 domain family member 25 (TBC1D25)	OT11OABF	TBC25_HUMAN	Increases Expression	[10]
Sigma intracellular receptor 2 (TMEM97)	OTH76ZWK	SGMR2_HUMAN	Increases Expression	[10]
Sterile alpha motif domain-containing protein 9 (SAMD9)	OTDG48P0	SAMD9_HUMAN	Increases Expression	[10]
Centrosomal protein of 162 kDa (CEP162)	OT39FSH8	CE162_HUMAN	Increases Expression	[10]
Telomere-associated protein RIF1 (RIF1)	OTPE49OE	RIF1_HUMAN	Increases Expression	[10]
La-related protein 4 (LARP4)	OTB10IJH	LARP4_HUMAN	Increases Expression	[10]
Centromere protein Q (CENPQ)	OT3M6WAI	CENPQ_HUMAN	Increases Expression	[10]
Protein MON2 homolog (MON2)	OTCSVMAR	MON2_HUMAN	Increases Expression	[10]
Adhesion G-protein coupled receptor G6 (ADGRG6)	OTY2UBXO	AGRG6_HUMAN	Increases Expression	[10]
Intraflagellar transport protein 70A (IFT70A)	OTX4FKPQ	IT70A_HUMAN	Increases Expression	[10]
Centrosomal protein of 57 kDa (CEP57)	OTPOHLIX	CEP57_HUMAN	Increases Expression	[10]
Bardet-Biedl syndrome 7 protein (BBS7)	OTELYWDQ	BBS7_HUMAN	Increases Expression	[10]
Abnormal spindle-like microcephaly-associated protein (ASPM)	OTKXQMNA	ASPM_HUMAN	Increases Expression	[10]
Lysosomal enzyme trafficking factor (LYSET)	OT8XE247	LYSET_HUMAN	Increases Expression	[10]
Estradiol 17-beta-dehydrogenase 11 (HSD17B11)	OT3VIM3B	DHB11_HUMAN	Increases Expression	[10]
Holliday junction recognition protein (HJURP)	OTWMV16B	HJURP_HUMAN	Increases Expression	[10]
Putative tyrosine carboxypeptidase MATCAP2 (MATCAP2)	OTZUC9LR	MACA2_HUMAN	Increases Expression	[10]
Bardet-Biedl syndrome 10 protein (BBS10)	OTL1TTWX	BBS10_HUMAN	Increases Expression	[10]
Centrosomal protein of 76 kDa (CEP76)	OTL2SJX0	CEP76_HUMAN	Increases Expression	[10]
Nuclear protein MDM1 (MDM1)	OTI9JUWA	MDM1_HUMAN	Increases Expression	[10]
Cyclic GMP-AMP phosphodiesterase SMPDL3A (SMPDL3A)	OTQDYH8E	ASM3A_HUMAN	Increases Expression	[10]
Homeobox protein DLX-4 (DLX4)	OTLWVCN4	DLX4_HUMAN	Increases Expression	[10]
Serine/threonine-protein kinase Sgk3 (SGK3)	OTQ6QO99	SGK3_HUMAN	Increases Expression	[10]
Autophagy-related protein 2 homolog B (ATG2B)	OT7FGFJ1	ATG2B_HUMAN	Increases Expression	[10]
Centromere protein N (CENPN)	OTRO7XPD	CENPN_HUMAN	Increases Expression	[10]
Fatty acid hydroxylase domain-containing protein 2 (FAXDC2)	OTRRS828	FXDC2_HUMAN	Increases Expression	[10]
Intraflagellar transport protein 74 homolog (IFT74)	OTZBFEDD	IFT74_HUMAN	Increases Expression	[10]
Krueppel-like factor 6 (KLF6)	OTQY9S7F	KLF6_HUMAN	Increases Expression	[10]
Cell division control protein 6 homolog (CDC6)	OTX93FE7	CDC6_HUMAN	Increases Expression	[10]
A-kinase anchor protein 9 (AKAP9)	OT7Z2YRP	AKAP9_HUMAN	Decreases Expression	[10]
Spondin-2 (SPON2)	OTE7JLNM	SPON2_HUMAN	Decreases Expression	[10]
Acetyl-CoA acetyltransferase, cytosolic (ACAT2)	OTZ092ZJ	THIC_HUMAN	Increases Expression	[10]
Homeodomain-interacting protein kinase 2 (HIPK2)	OTDB7QC3	HIPK2_HUMAN	Decreases Expression	[10]
PR domain zinc finger protein 12 (PRDM12)	OTOAUVAM	PRD12_HUMAN	Increases Expression	[10]
GS homeobox 1 (GSX1)	OTDZ5J1U	GSX1_HUMAN	Increases Expression	[10]
Very long chain fatty acid elongase 6 (ELOVL6)	OTB26UJJ	ELOV6_HUMAN	Increases Expression	[10]
Cation channel sperm-associated auxiliary subunit beta (CATSPERB)	OTZ0WQL2	CTSRB_HUMAN	Decreases Expression	[10]
Thiol S-methyltransferase TMT1A (TMT1A)	OT4IAAZP	TMT1A_HUMAN	Increases Expression	[10]
Synaptopodin 2-like protein (SYNPO2L)	OTA7RKXZ	SYP2L_HUMAN	Increases Expression	[10]
NADPH oxidase 3 (NOX3)	OT0FFJH8	NOX3_HUMAN	Decreases Expression	[10]
Mucin-5B (MUC5B)	OTPW6K5C	MUC5B_HUMAN	Increases Expression	[10]
Inward rectifier potassium channel 16 (KCNJ16)	OT174UPV	KCJ16_HUMAN	Increases Expression	[10]
PDZ and LIM domain protein 7 (PDLIM7)	OTAZVODU	PDLI7_HUMAN	Decreases Expression	[10]
Rho guanine nucleotide exchange factor 3 (ARHGEF3)	OTHGNC0A	ARHG3_HUMAN	Increases Expression	[10]
Inactive ubiquitin thioesterase OTULINL (OTULINL)	OTNOC9L1	OTULL_HUMAN	Increases Expression	[10]
Fanconi anemia group I protein (FANCI)	OTW8E3SC	FANCI_HUMAN	Increases Expression	[10]
Protein kintoun (DNAAF2)	OTB8YEJ5	KTU_HUMAN	Increases Expression	[10]
TBCC domain-containing protein 1 (TBCCD1)	OT8WZ1LN	TBCC1_HUMAN	Increases Expression	[10]
CDKN2A-interacting protein (CDKN2AIP)	OT80RRQJ	CARF_HUMAN	Increases Expression	[10]
Neurotrimin (NTM)	OTHF0UQU	NTRI_HUMAN	Decreases Expression	[10]
FERM domain-containing protein 4A (FRMD4A)	OTJDTIK2	FRM4A_HUMAN	Decreases Expression	[10]
7-dehydrocholesterol reductase (DHCR7)	OTLILBUI	DHCR7_HUMAN	Increases Expression	[10]
Short transient receptor potential channel 4 (TRPC4)	OTYY9DPV	TRPC4_HUMAN	Increases Expression	[10]
Transcription termination factor 2 (TTF2)	OT5LJOWM	TTF2_HUMAN	Increases Expression	[10]
HBS1-like protein (HBS1L)	OTA3U1N6	HBS1L_HUMAN	Increases Expression	[10]
Metal-response element-binding transcription factor 2 (MTF2)	OTNL1O2O	MTF2_HUMAN	Increases Expression	[10]
Lysyl oxidase homolog 2 (LOXL2)	OTRT46B5	LOXL2_HUMAN	Decreases Expression	[10]
Protocadherin gamma-A3 (PCDHGA3)	OTTOGYJA	PCDG3_HUMAN	Decreases Expression	[10]
Protocadherin gamma-A11 (PCDHGA11)	OTK9136T	PCDGB_HUMAN	Decreases Expression	[10]
Protocadherin gamma-A1 (PCDHGA1)	OTR1U1LI	PCDG1_HUMAN	Decreases Expression	[10]
Endothelial lipase (LIPG)	OTHEE942	LIPG_HUMAN	Increases Expression	[10]
Chloride intracellular channel protein 4 (CLIC4)	OT6KTPKD	CLIC4_HUMAN	Decreases Expression	[10]
Tolloid-like protein 2 (TLL2)	OTHZ4TBL	TLL2_HUMAN	Increases Expression	[10]
CTD small phosphatase-like protein (CTDSPL)	OTZJ0CZK	CTDSL_HUMAN	Increases Expression	[11]
Coagulation factor X (F10)	OT2BLK17	FA10_HUMAN	Increases Expression	[11]
Insulin-like growth factor II (IGF2)	OTJ4O6MW	IGF2_HUMAN	Increases Expression	[11]
Cathepsin D (CTSD)	OTQZ36F3	CATD_HUMAN	Increases Expression	[11]
Keratin, type II cytoskeletal 7 (KRT7)	OTLT3JFN	K2C7_HUMAN	Increases Expression	[11]
Transcriptional activator Myb (MYB)	OTJH64IV	MYB_HUMAN	Decreases Expression	[11]
Glycophorin-E (GYPE)	OTBHAG6A	GLPE_HUMAN	Increases Expression	[11]
Solute carrier family 25 member 16 (SLC25A16)	OTTTUL91	GDC_HUMAN	Increases Expression	[11]
Protein S100-P (S100P)	OTJCXNJG	S100P_HUMAN	Increases Expression	[11]
cGMP-gated cation channel alpha-1 (CNGA1)	OT0RXMJN	CNGA1_HUMAN	Increases Expression	[11]
M-phase inducer phosphatase 2 (CDC25B)	OT12MSRY	MPIP2_HUMAN	Increases Expression	[11]
Chitinase-3-like protein 1 (CHI3L1)	OT2Z7VJH	CH3L1_HUMAN	Increases Expression	[11]
ETS-related transcription factor Elf-3 (ELF3)	OTUTLEQO	ELF3_HUMAN	Increases Expression	[11]
Origin recognition complex subunit 2 (ORC2)	OTLIYP8M	ORC2_HUMAN	Increases Expression	[11]
Angio-associated migratory cell protein (AAMP)	OTZXBSS4	AAMP_HUMAN	Increases Expression	[11]
CD166 antigen (ALCAM)	OTCO4LP7	CD166_HUMAN	Increases Expression	[11]
FXYD domain-containing ion transport regulator 3 (FXYD3)	OT9PPRHE	FXYD3_HUMAN	Increases Expression	[11]
Nuclear mitotic apparatus protein 1 (NUMA1)	OTTKAVG4	NUMA1_HUMAN	Increases Expression	[11]
Programmed cell death protein 4 (PDCD4)	OTZ6NXUX	PDCD4_HUMAN	Increases Expression	[11]
Quinone oxidoreductase PIG3 (TP53I3)	OTSCM68G	QORX_HUMAN	Increases Expression	[11]
Disks large homolog 5 (DLG5)	OTU9Z17K	DLG5_HUMAN	Increases Expression	[11]
E3 ubiquitin-protein ligase RNF5 (RNF5)	OTDQGI37	RNF5_HUMAN	Increases Expression	[11]
Prostaglandin E synthase (PTGES)	OTB7YQFU	PTGES_HUMAN	Increases Expression	[12]
Decapping and exoribonuclease protein (DXO)	OTFDTNW4	DXO_HUMAN	Increases Expression	[12]
Natriuretic peptides A (NPPA)	OTMQNTNX	ANF_HUMAN	Increases Expression	[12]
Carcinoembryonic antigen-related cell adhesion molecule 1 (CEACAM1)	OTPWI88U	CEAM1_HUMAN	Increases Expression	[12]
CD44 antigen (CD44)	OT9TTJ41	CD44_HUMAN	Decreases Expression	[12]
Tenascin (TNC)	OTK4FSHR	TENA_HUMAN	Decreases Expression	[12]
Vascular endothelial growth factor receptor 2 (KDR)	OT15797V	VGFR2_HUMAN	Increases Expression	[12]
Aquaporin-2 (AQP2)	OTQLBKK6	AQP2_HUMAN	Increases Expression	[12]
Sodium- and chloride-dependent GABA transporter 3 (SLC6A11)	OT5F9PAE	S6A11_HUMAN	Decreases Expression	[12]
Matrix metalloproteinase-14 (MMP14)	OT9C197Z	MMP14_HUMAN	Increases Expression	[12]
Disintegrin and metalloproteinase domain-containing protein 17 (ADAM17)	OTTM6KRB	ADA17_HUMAN	Decreases Expression	[12]
C-X-C motif chemokine 9 (CXCL9)	OTMFVZKZ	CXCL9_HUMAN	Increases Expression	[12]
Amino acid transporter heavy chain SLC3A1 (SLC3A1)	OT56V01A	SLC31_HUMAN	Increases Expression	[12]
Matrix metalloproteinase-26 (MMP26)	OT9O89KU	MMP26_HUMAN	Decreases Expression	[12]
Nitric oxide synthase 3 (NOS3)	OTLDT7NR	NOS3_HUMAN	Increases Expression	[59]
Nitric oxide synthase, inducible (NOS2)	OTKKIOJ1	NOS2_HUMAN	Increases Expression	[59]
3-oxo-5-alpha-steroid 4-dehydrogenase 2 (SRD5A2)	OTTG0NFD	S5A2_HUMAN	Decreases Activity	[60]
Proteinase-activated receptor 3 (F2RL2)	OT982ECU	PAR3_HUMAN	Decreases Expression	[13]
Phospholipid phosphatase 3 (PLPP3)	OTSSF7BK	PLPP3_HUMAN	Increases Expression	[13]
Actin-binding LIM protein 1 (ABLIM1)	OTHXEK3E	ABLM1_HUMAN	Increases Expression	[13]
Inositol monophosphatase 2 (IMPA2)	OTNFB9YN	IMPA2_HUMAN	Increases Expression	[13]
Interferon regulatory factor 6 (IRF6)	OTKJ44EV	IRF6_HUMAN	Increases Expression	[13]
Inositol polyphosphate 4-phosphatase type II (INPP4B)	OTLROA7G	INP4B_HUMAN	Decreases Expression	[13]
Monocarboxylate transporter 7 (SLC16A6)	OT7BIIZX	MOT7_HUMAN	Decreases Expression	[13]
Prominin-1 (PROM1)	OTBHV8NX	PROM1_HUMAN	Decreases Expression	[13]
Phospholipid-transporting ATPase IC (ATP8B1)	OTALGS63	AT8B1_HUMAN	Decreases Expression	[13]
Unconventional myosin-Ib (MYO1B)	OTGZUJ0I	MYO1B_HUMAN	Decreases Expression	[13]
Plexin-C1 (PLXNC1)	OTJ5XKYY	PLXC1_HUMAN	Increases Expression	[13]
Tyrosine-protein kinase JAK2 (JAK2)	OTBIDOOR	JAK2_HUMAN	Increases Expression	[13]
ATP-binding cassette sub-family C member 9 (ABCC9)	OTGAXLQN	ABCC9_HUMAN	Increases Expression	[13]
Protein diaphanous homolog 2 (DIAPH2)	OTBEYFEZ	DIAP2_HUMAN	Increases Expression	[13]
Microphthalmia-associated transcription factor (MITF)	OT6XJCZH	MITF_HUMAN	Increases Expression	[13]
Integrin alpha-10 (ITGA10)	OTM0V5AO	ITA10_HUMAN	Increases Expression	[13]
A disintegrin and metalloproteinase with thrombospondin motifs 2 (ADAMTS2)	OTTK22NO	ATS2_HUMAN	Increases Expression	[13]
All-trans-retinol dehydrogenase ADH1B (ADH1B)	OTV3TB81	ADH1B_HUMAN	Increases Expression	[13]
Alcohol dehydrogenase 1C (ADH1C)	OTO1DV7F	ADH1G_HUMAN	Increases Expression	[13]
Insulin-like growth factor I (IGF1)	OTIIZR61	IGF1_HUMAN	Increases Expression	[13]
Insulin receptor (INSR)	OTTY341H	INSR_HUMAN	Increases Expression	[13]
Neurofilament medium polypeptide (NEFM)	OT8VCBNF	NFM_HUMAN	Decreases Expression	[13]
Complement factor H (CFH)	OTAGKQTJ	CFAH_HUMAN	Increases Expression	[13]
Interferon-induced protein with tetratricopeptide repeats 1 (IFIT1)	OTXOQDSG	IFIT1_HUMAN	Decreases Expression	[13]
Plastin-2 (LCP1)	OTK61F2A	PLSL_HUMAN	Increases Expression	[13]
Interleukin-1 receptor type 1 (IL1R1)	OTTU8959	IL1R1_HUMAN	Increases Expression	[13]
Atrial natriuretic peptide receptor 3 (NPR3)	OT6MQP3A	ANPRC_HUMAN	Increases Expression	[13]
Alpha-2C adrenergic receptor (ADRA2C)	OT5B9RKP	ADA2C_HUMAN	Increases Expression	[13]
Ras-related protein Rab-3B (RAB3B)	OTZA4SXL	RAB3B_HUMAN	Decreases Expression	[13]
Pleiotrophin (PTN)	OTYC7M2A	PTN_HUMAN	Decreases Expression	[13]
5'-nucleotidase (NT5E)	OT7J5LT6	5NTD_HUMAN	Decreases Expression	[13]
Glutathione peroxidase 3 (GPX3)	OT6PK94R	GPX3_HUMAN	Increases Expression	[13]
Ectonucleotide pyrophosphatase/phosphodiesterase family member 1 (ENPP1)	OT3MPPYX	ENPP1_HUMAN	Increases Expression	[13]
Insulin-like growth factor-binding protein 6 (IGFBP6)	OTW878VI	IBP6_HUMAN	Decreases Expression	[13]
Leiomodin-1 (LMOD1)	OTZ2MEMG	LMOD1_HUMAN	Increases Expression	[13]
Syndecan-4 (SDC4)	OTKUVUGZ	SDC4_HUMAN	Decreases Expression	[13]
Vasopressin V1a receptor (AVPR1A)	OTKR8AFL	V1AR_HUMAN	Increases Expression	[13]
ETS translocation variant 5 (ETV5)	OTE2OBM4	ETV5_HUMAN	Decreases Expression	[13]
DNA-binding protein inhibitor ID-4 (ID4)	OTPMJ39I	ID4_HUMAN	Increases Expression	[13]
Regulator of G-protein signaling 4 (RGS4)	OTG94HHL	RGS4_HUMAN	Decreases Expression	[13]
Epithelial membrane protein 2 (EMP2)	OTPS2H0L	EMP2_HUMAN	Increases Expression	[13]
ADP-ribosylation factor-like protein 4C (ARL4C)	OTQ3QNNU	ARL4C_HUMAN	Decreases Expression	[13]
Poly(rC)-binding protein 3 (PCBP3)	OT6EX9N6	PCBP3_HUMAN	Increases Expression	[13]
Anthrax toxin receptor 2 (ANTXR2)	OTOGFGOJ	ANTR2_HUMAN	Increases Expression	[13]
Actin, gamma-enteric smooth muscle (ACTG2)	OTRDWUO0	ACTH_HUMAN	Increases Expression	[13]
Mothers against decapentaplegic homolog 3 (SMAD3)	OTNA96MR	SMAD3_HUMAN	Decreases Expression	[13]
Beta-1,3-galactosyl-O-glycosyl-glycoprotein beta-1,6-N-acetylglucosaminyltransferase (GCNT1)	OTF6OC66	GCNT1_HUMAN	Increases Expression	[13]
Complement factor H-related protein 1 (CFHR1)	OT72R16T	FHR1_HUMAN	Increases Expression	[13]
Adenylate cyclase type 1 (ADCY1)	OTSLLFZO	ADCY1_HUMAN	Increases Expression	[13]
Forkhead box protein O1 (FOXO1)	OTPJRB6D	FOXO1_HUMAN	Increases Expression	[13]
A-kinase anchor protein 13 (AKAP13)	OTOZAR14	AKP13_HUMAN	Increases Expression	[13]
Monocyte to macrophage differentiation factor (MMD)	OTB5I4OC	PAQRB_HUMAN	Increases Expression	[13]
CD226 antigen (CD226)	OT4UG0KB	CD226_HUMAN	Increases Expression	[13]
Nuclear factor interleukin-3-regulated protein (NFIL3)	OTQH9HM3	NFIL3_HUMAN	Increases Expression	[13]
Dual specificity protein phosphatase 6 (DUSP6)	OT4H6RKW	DUS6_HUMAN	Decreases Expression	[13]
FH1/FH2 domain-containing protein 3 (FHOD3)	OT1WUBQX	FHOD3_HUMAN	Decreases Expression	[13]
Galectin-related protein (LGALSL)	OTC983KJ	LEGL_HUMAN	Decreases Expression	[13]
PWWP domain-containing DNA repair factor 3B (PWWP3B)	OTOV6EM9	PWP3B_HUMAN	Increases Expression	[13]
Sickle tail protein homolog (KIAA1217)	OTRMK3PU	SKT_HUMAN	Increases Expression	[13]
Protein furry homolog (FRY)	OT74IAG2	FRY_HUMAN	Decreases Expression	[13]
Olfactomedin-like protein 2B (OLFML2B)	OTDNJFR4	OLM2B_HUMAN	Increases Expression	[13]
Coiled-coil domain-containing protein 102B (CCDC102B)	OTVDZVD0	C102B_HUMAN	Increases Expression	[13]
Protein Jade-1 (JADE1)	OTBPJIRI	JADE1_HUMAN	Increases Expression	[13]
Protein TMED8 (TMED8)	OTPVXP0K	TMED8_HUMAN	Increases Expression	[13]
Ras-like protein family member 11A (RASL11A)	OTDO6CMY	RSLBA_HUMAN	Increases Expression	[13]
Ceramide synthase 6 (CERS6)	OTOP4GV1	CERS6_HUMAN	Increases Expression	[13]
Patched domain-containing protein 4 (PTCHD4)	OTGJ8NRP	PTHD4_HUMAN	Decreases Expression	[13]
Chondroitin sulfate synthase 3 (CHSY3)	OT8ERGMH	CHSS3_HUMAN	Increases Expression	[13]
Lysosomal proton-coupled steroid conjugate and bile acid symporter SLC46A3 (SLC46A3)	OTEMDLPS	S46A3_HUMAN	Increases Expression	[13]
Target of Nesh-SH3 (ABI3BP)	OTW8DN50	TARSH_HUMAN	Increases Expression	[13]
MOB kinase activator 3B (MOB3B)	OTZJQG1D	MOB3B_HUMAN	Increases Expression	[13]
SEC14 domain and spectrin repeat-containing protein 1 (SESTD1)	OTHH06X8	SESD1_HUMAN	Increases Expression	[13]
Proline-rich protein 15 (PRR15)	OTJHSY8G	PRR15_HUMAN	Increases Expression	[13]
Neuron navigator 3 (NAV3)	OT97M1TR	NAV3_HUMAN	Decreases Expression	[13]
Beta-galactosidase-1-like protein 2 (GLB1L2)	OTLI6HCH	GLBL2_HUMAN	Increases Expression	[13]
Extracellular sulfatase Sulf-2 (SULF2)	OTIXMUVL	SULF2_HUMAN	Increases Expression	[13]
CD302 antigen (CD302)	OTX580VU	CD302_HUMAN	Increases Expression	[13]
Myocardin (MYOCD)	OTSJNHTH	MYCD_HUMAN	Increases Expression	[13]
Protein APCDD1 (APCDD1)	OTV9AD0L	APCD1_HUMAN	Increases Expression	[13]
Protein odd-skipped-related 2 (OSR2)	OTYG371T	OSR2_HUMAN	Increases Expression	[13]
Protein FAM43A (FAM43A)	OT5RPQRE	FA43A_HUMAN	Decreases Expression	[13]
Rho GTPase-activating protein 18 (ARHGAP18)	OTYMJP6H	RHG18_HUMAN	Decreases Expression	[13]
Chemokine-like protein TAFA-2 (TAFA2)	OTU6WP6J	TAFA2_HUMAN	Increases Expression	[13]
Actin filament-associated protein 1-like 2 (AFAP1L2)	OTJBI0VN	AF1L2_HUMAN	Decreases Expression	[13]
Sterile alpha motif domain-containing protein 12 (SAMD12)	OTIFG9O6	SAM12_HUMAN	Decreases Expression	[13]
Coiled-coil domain-containing protein 71L (CCDC71L)	OT7ECVUW	CC71L_HUMAN	Decreases Expression	[13]
Kelch-like protein 23 (KLHL23)	OT2UVSD2	KLH23_HUMAN	Increases Expression	[13]
1-acylglycerol-3-phosphate O-acyltransferase ABHD5 (ABHD5)	OTY829Z3	ABHD5_HUMAN	Increases Expression	[13]
Voltage-dependent calcium channel gamma-like subunit (TMEM37)	OT317PEL	CCGL_HUMAN	Increases Expression	[13]
Alpha-N-acetylneuraminide alpha-2,8-sialyltransferase (ST8SIA1)	OTGND2YZ	SIA8A_HUMAN	Decreases Expression	[13]
Serine palmitoyltransferase small subunit A (SPTSSA)	OT2PNKOP	SPTSA_HUMAN	Increases Expression	[13]
Fermitin family homolog 2 (FERMT2)	OTZNPWWX	FERM2_HUMAN	Increases Expression	[13]
SPRY domain-containing SOCS box protein 1 (SPSB1)	OTGY26U4	SPSB1_HUMAN	Increases Expression	[13]
Synaptotagmin-like protein 4 (SYTL4)	OT7MX5IK	SYTL4_HUMAN	Increases Expression	[13]
Isochorismatase domain-containing protein 1 (ISOC1)	OTAO7Z87	ISOC1_HUMAN	Decreases Expression	[13]
Cytoplasmic FMR1-interacting protein 2 (CYFIP2)	OTCAY35T	CYFP2_HUMAN	Decreases Expression	[13]
Leucine-rich repeats and immunoglobulin-like domains protein 1 (LRIG1)	OTY5HZN5	LRIG1_HUMAN	Increases Expression	[13]
Lysyl oxidase homolog 4 (LOXL4)	OT6XY2JL	LOXL4_HUMAN	Decreases Expression	[13]
Solute carrier family 41 member 2 (SLC41A2)	OT8EB4TF	S41A2_HUMAN	Increases Expression	[13]
Guanylate-binding protein 4 (GBP4)	OTSPNGKX	GBP4_HUMAN	Decreases Expression	[13]
Sortilin (SORT1)	OTFCQ4B1	SORT_HUMAN	Increases Expression	[13]
Methionine synthase (MTR)	OTF2K2TA	METH_HUMAN	Increases Expression	[13]
Osteomodulin (OMD)	OTFRELBB	OMD_HUMAN	Increases Expression	[13]
EF-hand domain-containing protein D1 (EFHD1)	OTL5INE4	EFHD1_HUMAN	Increases Expression	[13]
Sorbin and SH3 domain-containing protein 1 (SORBS1)	OTWH8762	SRBS1_HUMAN	Increases Expression	[13]
Atypical chemokine receptor 4 (ACKR4)	OTZPWT2N	ACKR4_HUMAN	Decreases Expression	[13]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase beta-1 (PLCB1)	OT9HYT7A	PLCB1_HUMAN	Decreases Expression	[13]
SNF-related serine/threonine-protein kinase (SNRK)	OTX0OPHO	SNRK_HUMAN	Decreases Expression	[13]
G-protein coupled receptor family C group 5 member B (GPRC5B)	OTF3S5E3	GPC5B_HUMAN	Increases Expression	[13]
Phosphatidylethanolamine N-methyltransferase (PEMT)	OTKXRUL9	PEMT_HUMAN	Increases Expression	[13]
E3 ISG15--protein ligase HERC5 (HERC5)	OTZ5PR39	HERC5_HUMAN	Decreases Expression	[13]
ERBB receptor feedback inhibitor 1 (ERRFI1)	OT7VZ2IZ	ERRFI_HUMAN	Increases Expression	[13]
Potassium channel subfamily K member 6 (KCNK6)	OTCY281R	KCNK6_HUMAN	Increases Expression	[13]
Atrial natriuretic peptide-converting enzyme (CORIN)	OT4SK7DK	CORIN_HUMAN	Increases Expression	[13]
LHFPL tetraspan subfamily member 6 protein (LHFPL6)	OTY6LHJY	LHPL6_HUMAN	Increases Expression	[13]
Mitogen-activated protein kinase kinase kinase 4 (MAP3K4)	OTTFQVRC	M3K4_HUMAN	Increases Expression	[13]
Protein FAM181B (FAM181B)	OTGZHJ7K	F181B_HUMAN	Increases Expression	[14]
Ribonuclease T2 (RNASET2)	OTWY64L7	RNT2_HUMAN	Decreases Expression	[14]
Beta-1,3-N-acetylglucosaminyltransferase manic fringe (MFNG)	OTUX45ZF	MFNG_HUMAN	Increases Expression	[14]
Calmegin (CLGN)	OTEWVFQV	CLGN_HUMAN	Decreases Expression	[14]
Mothers against decapentaplegic homolog 9 (SMAD9)	OTK4M1H8	SMAD9_HUMAN	Decreases Expression	[14]
Polyunsaturated fatty acid lipoxygenase ALOX15B (ALOX15B)	OTWQQ08W	LX15B_HUMAN	Increases Expression	[14]
Cationic amino acid transporter 4 (SLC7A4)	OTAVC6QS	CTR4_HUMAN	Decreases Expression	[14]
Keratin, type II cuticular Hb6 (KRT86)	OT93MMAK	KRT86_HUMAN	Increases Expression	[14]
Myelin protein zero-like protein 2 (MPZL2)	OTKFNDUI	MPZL2_HUMAN	Decreases Expression	[14]
Toll-like receptor 5 (TLR5)	OT8ZYKJ6	TLR5_HUMAN	Decreases Expression	[14]
Short-chain dehydrogenase/reductase 3 (DHRS3)	OTSK1DTP	DHRS3_HUMAN	Increases Expression	[14]
Organic cation/carnitine transporter 2 (SLC22A5)	OTC36TYB	S22A5_HUMAN	Increases Expression	[14]
High affinity cGMP-specific 3',5'-cyclic phosphodiesterase 9A (PDE9A)	OT4U3QHF	PDE9A_HUMAN	Decreases Expression	[14]
Sorbin and SH3 domain-containing protein 2 (SORBS2)	OTJSX44Y	SRBS2_HUMAN	Decreases Expression	[14]
Fibrinogen beta chain (FGB)	OT6RKLI9	FIBB_HUMAN	Increases Expression	[14]
Sodium/potassium-transporting ATPase subunit beta-1 (ATP1B1)	OTTO6ZP4	AT1B1_HUMAN	Decreases Expression	[14]
Integrin beta-2 (ITGB2)	OTEKPEPR	ITB2_HUMAN	Increases Expression	[14]
Plasma protease C1 inhibitor (SERPING1)	OT6CVN45	IC1_HUMAN	Increases Expression	[14]
Propionyl-CoA carboxylase alpha chain, mitochondrial (PCCA)	OTWJTCRK	PCCA_HUMAN	Decreases Expression	[14]
Alkaline phosphatase, tissue-nonspecific isozyme (ALPL)	OTG7J4BP	PPBT_HUMAN	Decreases Expression	[14]
Keratin, type II cytoskeletal 8 (KRT8)	OTTM4X11	K2C8_HUMAN	Decreases Expression	[14]
Low affinity immunoglobulin gamma Fc region receptor III-A (FCGR3A)	OTOWXCF3	FCG3A_HUMAN	Increases Expression	[14]
Annexin A3 (ANXA3)	OTDD8OI7	ANXA3_HUMAN	Decreases Expression	[14]
Hematopoietic lineage cell-specific protein (HCLS1)	OTX7WGYN	HCLS1_HUMAN	Increases Expression	[14]
Interferon gamma receptor 1 (IFNGR1)	OTCTQBWW	INGR1_HUMAN	Decreases Expression	[14]
Lipopolysaccharide-binding protein (LBP)	OTQXAH4L	LBP_HUMAN	Increases Expression	[14]
Protein-glutamine gamma-glutamyltransferase 2 (TGM2)	OT6MFOWF	TGM2_HUMAN	Increases Expression	[14]
Endothelin receptor type B (EDNRB)	OTLLZV3P	EDNRB_HUMAN	Increases Expression	[14]
5-hydroxytryptamine receptor 2A (HTR2A)	OTWXJX0M	5HT2A_HUMAN	Increases Expression	[14]
Glutathione hydrolase 5 proenzyme (GGT5)	OTDJYEO7	GGT5_HUMAN	Increases Expression	[14]
GMP reductase 1 (GMPR)	OTERWHYM	GMPR1_HUMAN	Decreases Expression	[14]
Amiloride-sensitive sodium channel subunit alpha (SCNN1A)	OTE2KVZV	SCNNA_HUMAN	Decreases Expression	[14]
Excitatory amino acid transporter 3 (SLC1A1)	OT3B9M6W	EAA3_HUMAN	Increases Expression	[14]
ATP-binding cassette sub-family G member 1 (ABCG1)	OT5BG6MK	ABCG1_HUMAN	Decreases Expression	[14]
Glioma pathogenesis-related protein 1 (GLIPR1)	OT0FGQK7	GLIP1_HUMAN	Increases Expression	[14]
Retinoic acid receptor responder protein 1 (RARRES1)	OTETUPP5	TIG1_HUMAN	Increases Expression	[14]
Cysteine-rich protein 1 (CRIP1)	OT0EICG3	CRIP1_HUMAN	Decreases Expression	[14]
Lumican (LUM)	OTSRC874	LUM_HUMAN	Increases Expression	[14]
Growth arrest-specific protein 1 (GAS1)	OTKJXG52	GAS1_HUMAN	Increases Expression	[14]
Microfibril-associated glycoprotein 4 (MFAP4)	OT5W64QY	MFAP4_HUMAN	Increases Expression	[14]
Prokineticin-1 (PROK1)	OT8S7RUG	PROK1_HUMAN	Increases Expression	[14]
Ras-related protein Rab-15 (RAB15)	OTU0GGR3	RAB15_HUMAN	Decreases Expression	[14]
FXYD domain-containing ion transport regulator 4 (FXYD4)	OT06IH3H	FXYD4_HUMAN	Decreases Expression	[14]
Rho-related GTP-binding protein RhoE (RND3)	OTXMXPIH	RND3_HUMAN	Increases Expression	[14]
Troponin C, slow skeletal and cardiac muscles (TNNC1)	OT9A0FL4	TNNC1_HUMAN	Decreases Expression	[14]
Transducin-like enhancer protein 2 (TLE2)	OT2KSZ9B	TLE2_HUMAN	Increases Expression	[14]
Aldehyde oxidase (AOX1)	OT2FZP6H	AOXA_HUMAN	Increases Expression	[14]
NKG2-E type II integral membrane protein (KLRC3)	OT9EPHV3	NKG2E_HUMAN	Increases Expression	[14]
Regulator of G-protein signaling 1 (RGS1)	OTGXJYMG	RGS1_HUMAN	Increases Expression	[14]
Ankyrin-3 (ANK3)	OTJ3IRBP	ANK3_HUMAN	Decreases Expression	[14]
Protein AF1q (MLLT11)	OTG5RVHC	AF1Q_HUMAN	Increases Expression	[14]
Multimerin-1 (MMRN1)	OT7ZNYHT	MMRN1_HUMAN	Increases Expression	[14]
Protein phosphatase 1 regulatory subunit 1A (PPP1R1A)	OTGTAGCV	PPR1A_HUMAN	Decreases Expression	[14]
Calcium/calmodulin-dependent protein kinase type II subunit beta (CAMK2B)	OTS9YK3E	KCC2B_HUMAN	Decreases Expression	[14]
Hyaluronan-binding protein 2 (HABP2)	OTAUIPW0	HABP2_HUMAN	Increases Expression	[14]
Receptor-type tyrosine-protein phosphatase R (PTPRR)	OT790UA2	PTPRR_HUMAN	Increases Expression	[14]
Adipogenesis regulatory factor (ADIRF)	OTTJP8D4	ADIRF_HUMAN	Decreases Expression	[14]
Solute carrier family 15 member 2 (SLC15A2)	OTDV7YES	S15A2_HUMAN	Decreases Expression	[14]
Laminin subunit alpha-4 (LAMA4)	OTHI7TA0	LAMA4_HUMAN	Increases Expression	[14]
Diacylglycerol kinase delta (DGKD)	OTNI8HAH	DGKD_HUMAN	Decreases Expression	[14]
Tumor protein D53 (TPD52L1)	OTSA6U0I	TPD53_HUMAN	Decreases Expression	[14]
Protein FAM110C (FAM110C)	OTI5V72M	F110C_HUMAN	Decreases Expression	[14]
Inhibitory synaptic factor 1 (INSYN1)	OTPKEFNC	INSY1_HUMAN	Decreases Expression	[14]
Filamin A-interacting protein 1-like (FILIP1L)	OTPY8IMS	FIL1L_HUMAN	Increases Expression	[14]
Keratinocyte-associated protein 3 (KRTCAP3)	OTB24J5O	KCP3_HUMAN	Decreases Expression	[14]
OCIA domain-containing protein 2 (OCIAD2)	OTSWB4SZ	OCAD2_HUMAN	Decreases Expression	[14]
Calcium homeostasis modulator protein 6 (CALHM6)	OTLX9B4Y	CAHM6_HUMAN	Increases Expression	[14]
Transcription factor HES-5 (HES5)	OTW7JEHV	HES5_HUMAN	Decreases Expression	[14]
Mitochondrial amidoxime-reducing component 1 (MTARC1)	OTNBE033	MARC1_HUMAN	Decreases Expression	[14]
Carboxylesterase 4A (CES4A)	OT0Q5JEU	EST4A_HUMAN	Decreases Expression	[14]
TMF-regulated nuclear protein 1 (TRNP1)	OTYYV8LN	TRNP1_HUMAN	Increases Expression	[14]
Ribosomal protein eL22-like (RPL22L1)	OTNWGF5C	RL22L_HUMAN	Increases Expression	[14]
Surfactant-associated protein 2 (SFTA2)	OTVRIUIV	SFTA2_HUMAN	Decreases Expression	[14]
Isoaspartyl peptidase/L-asparaginase (ASRGL1)	OTNGNRBA	ASGL1_HUMAN	Decreases Expression	[14]
RAS guanyl-releasing protein 2 (RASGRP2)	OTABVLVQ	GRP2_HUMAN	Increases Expression	[14]
Calcium-dependent secretion activator 2 (CADPS2)	OTV1FW0M	CAPS2_HUMAN	Increases Expression	[14]
Enoyl-CoA hydratase domain-containing protein 2, mitochondrial (ECHDC2)	OTL0DWCO	ECHD2_HUMAN	Decreases Expression	[14]
Transmembrane protein 139 (TMEM139)	OTZA6I9L	TM139_HUMAN	Decreases Expression	[14]
Prolyl 3-hydroxylase 2 (P3H2)	OTY84H6U	P3H2_HUMAN	Increases Expression	[14]
Beta/gamma crystallin domain-containing protein 2 (CRYBG2)	OTTPFG2M	CRBG2_HUMAN	Decreases Expression	[14]
Ankyrin repeat domain-containing protein 35 (ANKRD35)	OTFF5JP6	ANR35_HUMAN	Decreases Expression	[14]
Xylosyl- and glucuronyltransferase LARGE2 (LARGE2)	OT5BZS3J	LARG2_HUMAN	Decreases Expression	[14]
Mitochondrial basic amino acids transporter (SLC25A29)	OT09PIFE	S2529_HUMAN	Decreases Expression	[14]
Carbohydrate sulfotransferase 4 (CHST4)	OTESMIW5	CHST4_HUMAN	Decreases Expression	[14]
SLAIN motif-containing protein 1 (SLAIN1)	OTMT25MN	SLAI1_HUMAN	Decreases Expression	[14]
Transient receptor potential cation channel subfamily M member 4 (TRPM4)	OT354X8E	TRPM4_HUMAN	Decreases Expression	[14]
E3 ubiquitin-protein ligase SH3RF2 (SH3RF2)	OT2IVOK4	SH3R2_HUMAN	Decreases Expression	[14]
Glucose-6-phosphate exchanger SLC37A2 (SLC37A2)	OTH77FBE	G6PT3_HUMAN	Decreases Expression	[14]
DEP domain-containing protein 1B (DEPDC1B)	OTMVFOT1	DEP1B_HUMAN	Increases Expression	[14]
Transcription factor GATA-6 (GATA6)	OTO2BC0F	GATA6_HUMAN	Increases Expression	[14]
Homogentisate 1,2-dioxygenase (HGD)	OTTKLQOO	HGD_HUMAN	Decreases Expression	[14]
Kazal-type serine protease inhibitor domain-containing protein 1 (KAZALD1)	OTSFOX2H	KAZD1_HUMAN	Decreases Expression	[14]
Cytosolic non-specific dipeptidase (CNDP2)	OTJR9436	CNDP2_HUMAN	Decreases Expression	[14]
Glycosyltransferase 1 domain-containing protein 1 (GLT1D1)	OTXW0WXJ	GL1D1_HUMAN	Increases Expression	[14]
Protein orai-2 (ORAI2)	OTYISRYH	ORAI2_HUMAN	Decreases Expression	[14]
Leucine-rich repeat-containing protein 1 (LRRC1)	OTSVD30Q	LRRC1_HUMAN	Decreases Expression	[14]
Melanophilin (MLPH)	OT7ADCXL	MELPH_HUMAN	Increases Expression	[14]
PGAP2-interacting protein (CWH43)	OTT3DPRH	PG2IP_HUMAN	Decreases Expression	[14]
Kinetochore protein Spc25 (SPC25)	OTCAS0OH	SPC25_HUMAN	Increases Expression	[14]
Neurexin-3-beta (NRXN3)	OTJ0I7HJ	NRX3B_HUMAN	Decreases Expression	[14]
ABC-type oligopeptide transporter ABCB9 (ABCB9)	OTSOBOL5	ABCB9_HUMAN	Decreases Expression	[14]
Carbohydrate sulfotransferase 11 (CHST11)	OTNJJ5Q1	CHSTB_HUMAN	Increases Expression	[14]
Dual oxidase 1 (DUOX1)	OTQ2AEW0	DUOX1_HUMAN	Decreases Expression	[14]
Transmembrane protein 45A (TMEM45A)	OT54KJG6	TM45A_HUMAN	Increases Expression	[14]
Syntabulin (SYBU)	OT3FQV7N	SYBU_HUMAN	Decreases Expression	[14]
Probable ATP-dependent RNA helicase DDX43 (DDX43)	OTK1RYSK	DDX43_HUMAN	Decreases Expression	[14]
Transcription factor CP2-like protein 1 (TFCP2L1)	OT7QIJ0X	TF2L1_HUMAN	Decreases Expression	[14]
A disintegrin and metalloproteinase with thrombospondin motifs 9 (ADAMTS9)	OTV3Q0DS	ATS9_HUMAN	Increases Expression	[14]
E3 ubiquitin-protein ligase CBL-C (CBLC)	OT3RKZI9	CBLC_HUMAN	Decreases Expression	[14]
Protein NDRG2 (NDRG2)	OT5L6KD7	NDRG2_HUMAN	Decreases Expression	[14]
Epididymis-specific alpha-mannosidase (MAN2B2)	OTU9V3PE	MA2B2_HUMAN	Decreases Expression	[14]
Sorting nexin-10 (SNX10)	OT05B7BT	SNX10_HUMAN	Increases Expression	[14]
Integrin alpha-M (ITGAM)	OTAG6HWU	ITAM_HUMAN	Decreases Expression	[61]
Gap junction alpha-1 protein (GJA1)	OTT94MKL	CXA1_HUMAN	Decreases Expression	[61]
Gap junction beta-2 protein (GJB2)	OTBKLEYB	CXB2_HUMAN	Decreases Expression	[61]
Transcription factor E2F8 (E2F8)	OTQKZGFP	E2F8_HUMAN	Decreases Expression	[15]
Ras-related protein Rab-27B (RAB27B)	OTPF9D0K	RB27B_HUMAN	Increases Expression	[15]
Matrilin-2 (MATN2)	OTVDR68G	MATN2_HUMAN	Increases Expression	[15]
Aurora kinase A (AURKA)	OTMX0HYT	AURKA_HUMAN	Decreases Expression	[15]
E3 ubiquitin-protein ligase Midline-1 (MID1)	OTWN1PGU	TRI18_HUMAN	Decreases Expression	[15]
Baculoviral IAP repeat-containing protein 5 (BIRC5)	OTILXZYL	BIRC5_HUMAN	Decreases Expression	[15]
ATP-binding cassette sub-family C member 3 (ABCC3)	OTC3IJV4	MRP3_HUMAN	Increases Expression	[15]
Disintegrin and metalloproteinase domain-containing protein 12 (ADAM12)	OTZKOTDB	ADA12_HUMAN	Decreases Expression	[15]
Mothers against decapentaplegic homolog 6 (SMAD6)	OTUZZWUD	SMAD6_HUMAN	Decreases Expression	[15]
Protein sprouty homolog 1 (SPRY1)	OT764FXI	SPY1_HUMAN	Increases Expression	[15]
Protein regulator of cytokinesis 1 (PRC1)	OTHD0XS0	PRC1_HUMAN	Decreases Expression	[15]
Mitotic checkpoint serine/threonine-protein kinase BUB1 beta (BUB1B)	OT8KME51	BUB1B_HUMAN	Decreases Expression	[15]
Monocarboxylate transporter 2 (SLC16A7)	OT7OI36B	MOT2_HUMAN	Decreases Expression	[15]
Thiamine transporter 1 (SLC19A2)	OTH5SB0M	S19A2_HUMAN	Increases Expression	[15]
Hyaluronan mediated motility receptor (HMMR)	OT4M0JTZ	HMMR_HUMAN	Decreases Expression	[15]
Tumor necrosis factor receptor superfamily member 21 (TNFRSF21)	OT3EDGXO	TNR21_HUMAN	Increases Expression	[15]
SEC14-like protein 2 (SEC14L2)	OTJST64D	S14L2_HUMAN	Increases Expression	[15]
G2/mitotic-specific cyclin-B2 (CCNB2)	OTIEXTDK	CCNB2_HUMAN	Decreases Expression	[15]
Kinesin-like protein KIF20A (KIF20A)	OTXOQHE0	KI20A_HUMAN	Decreases Expression	[15]
Chromosome-associated kinesin KIF4A (KIF4A)	OT3UWL7D	KIF4A_HUMAN	Decreases Expression	[15]
Cholesterol 25-hydroxylase (CH25H)	OT9S2BSW	CH25H_HUMAN	Decreases Expression	[15]
Tissue-type plasminogen activator (PLAT)	OTQPDNAB	TPA_HUMAN	Increases Expression	[15]
Myc proto-oncogene protein (MYC)	OTPV5LUK	MYC_HUMAN	Increases Expression	[15]
Angiogenin (ANG)	OT3ECS6P	ANGI_HUMAN	Increases Expression	[15]
Thymidine kinase, cytosolic (TK1)	OTY5JFM1	KITH_HUMAN	Decreases Expression	[15]
Metallothionein-1F (MT1F)	OTZVUYG1	MT1F_HUMAN	Increases Expression	[15]
Interleukin-6 (IL6)	OTUOSCCU	IL6_HUMAN	Increases Expression	[15]
Keratin, type I cytoskeletal 18 (KRT18)	OTVLQFIP	K1C18_HUMAN	Decreases Expression	[15]
Inhibin beta B chain (INHBB)	OT2QLD11	INHBB_HUMAN	Increases Expression	[15]
Thymosin beta-15A (TMSB15A)	OTSBWCES	TB15A_HUMAN	Decreases Expression	[15]
Interleukin-8 (CXCL8)	OTS7T5VH	IL8_HUMAN	Increases Expression	[15]
Hyaluronan and proteoglycan link protein 1 (HAPLN1)	OTXWR9TJ	HPLN1_HUMAN	Decreases Expression	[15]
Microtubule-associated protein 2 (MAP2)	OT6UYT3X	MTAP2_HUMAN	Decreases Expression	[15]
DNA topoisomerase 2-alpha (TOP2A)	OT6LPS08	TOP2A_HUMAN	Decreases Expression	[15]
Integrin alpha-4 (ITGA4)	OTSCAL0V	ITA4_HUMAN	Decreases Expression	[15]
Myosin light chain 6B (MYL6B)	OTWTRGT7	MYL6B_HUMAN	Decreases Expression	[15]
Interleukin-7 receptor subunit alpha (IL7R)	OTBMFLQQ	IL7RA_HUMAN	Decreases Expression	[15]
Early growth response protein 1 (EGR1)	OTCP6XGZ	EGR1_HUMAN	Increases Expression	[15]
Lamin-B1 (LMNB1)	OT100T3P	LMNB1_HUMAN	Decreases Expression	[15]
Anosmin-1 (ANOS1)	OTZJT4KN	KALM_HUMAN	Decreases Expression	[15]
Signal transducer CD24 (CD24)	OT7CODJ4	CD24_HUMAN	Decreases Expression	[15]
Endothelin-1 receptor (EDNRA)	OTK9T5O3	EDNRA_HUMAN	Decreases Expression	[15]
Pentraxin-related protein PTX3 (PTX3)	OTPXHRKU	PTX3_HUMAN	Increases Expression	[15]
G0/G1 switch protein 2 (G0S2)	OT8FL49L	G0S2_HUMAN	Increases Expression	[15]
Dual specificity protein phosphatase 1 (DUSP1)	OTN6BR75	DUS1_HUMAN	Increases Expression	[15]
11-beta-hydroxysteroid dehydrogenase 1 (HSD11B1)	OTO7FJA9	DHI1_HUMAN	Increases Expression	[15]
Ephrin type-A receptor 3 (EPHA3)	OTZJF3ML	EPHA3_HUMAN	Increases Expression	[15]
Somatostatin receptor type 1 (SSTR1)	OTFAGWO7	SSR1_HUMAN	Decreases Expression	[15]
Ribonucleoside-diphosphate reductase subunit M2 (RRM2)	OTOB6J6R	RIR2_HUMAN	Decreases Expression	[15]
Cystathionine gamma-lyase (CTH)	OTC90LA0	CGL_HUMAN	Increases Expression	[15]
DNA replication licensing factor MCM5 (MCM5)	OTAHLB62	MCM5_HUMAN	Decreases Expression	[15]
Ribonuclease 4 (RNASE4)	OTA5SZLC	RNAS4_HUMAN	Increases Expression	[15]
Cystathionine beta-synthase (CBS)	OT46FSKD	CBS_HUMAN	Increases Expression	[15]
Myosin-10 (MYH10)	OTXN2WXS	MYH10_HUMAN	Decreases Expression	[15]
Pigment epithelium-derived factor (SERPINF1)	OTWZH98J	PEDF_HUMAN	Increases Expression	[15]
TGF-beta receptor type-2 (TGFBR2)	OT3P7GZP	TGFR2_HUMAN	Increases Expression	[15]
Eukaryotic translation initiation factor 1 (EIF1)	OTB4GZ0V	EIF1_HUMAN	Increases Expression	[15]
5-hydroxytryptamine receptor 2B (HTR2B)	OTM1AD9J	5HT2B_HUMAN	Decreases Expression	[15]
Glutamate receptor 1 (GRIA1)	OT85LOCJ	GRIA1_HUMAN	Increases Expression	[15]
Neutral amino acid transporter A (SLC1A4)	OTVODHAE	SATT_HUMAN	Increases Expression	[15]
Prostaglandin F2-alpha receptor (PTGFR)	OTUI456H	PF2R_HUMAN	Increases Expression	[15]
Prostaglandin E2 receptor EP2 subtype (PTGER2)	OT1AUZAA	PE2R2_HUMAN	Increases Expression	[15]
Stromal cell-derived factor 1 (CXCL12)	OT2QX5LL	SDF1_HUMAN	Decreases Expression	[15]
Tissue factor pathway inhibitor 2 (TFPI2)	OTZCRWOR	TFPI2_HUMAN	Increases Expression	[15]
Nestin (NES)	OTZ9PZ14	NEST_HUMAN	Decreases Expression	[15]
MARCKS-related protein (MARCKSL1)	OT13J2FM	MRP_HUMAN	Decreases Expression	[15]
Histone H3-like centromeric protein A (CENPA)	OT0NEJ4X	CENPA_HUMAN	Decreases Expression	[15]
Calponin-1 (CNN1)	OTVPG39Z	CNN1_HUMAN	Decreases Expression	[15]
Serine/threonine-protein kinase Nek2 (NEK2)	OT1H27HO	NEK2_HUMAN	Decreases Expression	[15]
Sodium/myo-inositol cotransporter (SLC5A3)	OT6FY2KA	SC5A3_HUMAN	Decreases Expression	[15]
Smoothelin (SMTN)	OT4R2TYK	SMTN_HUMAN	Decreases Expression	[15]
Paired mesoderm homeobox protein 1 (PRRX1)	OTTZK5G8	PRRX1_HUMAN	Decreases Expression	[15]
Period circadian protein homolog 3 (PER3)	OTVKYVJA	PER3_HUMAN	Decreases Expression	[15]
Protein S100-A10 (S100A10)	OTI71243	S10AA_HUMAN	Increases Expression	[15]
Actin, alpha cardiac muscle 1 (ACTC1)	OTJU04B1	ACTC_HUMAN	Decreases Expression	[15]
Interleukin-13 receptor subunit alpha-1 (IL13RA1)	OT59OYXP	I13R1_HUMAN	Decreases Expression	[15]
Cyclic AMP-responsive element-binding protein 5 (CREB5)	OTJDUJPI	CREB5_HUMAN	Decreases Expression	[15]
A-kinase anchor protein 12 (AKAP12)	OTCVRDDX	AKA12_HUMAN	Increases Expression	[15]
Activin receptor type-1 (ACVR1)	OT4JATFE	ACVR1_HUMAN	Decreases Expression	[15]
3',5'-cyclic-AMP phosphodiesterase 4B (PDE4B)	OTOA8WU2	PDE4B_HUMAN	Decreases Expression	[15]
Homeobox protein DLX-2 (DLX2)	OTKC2DQ0	DLX2_HUMAN	Decreases Expression	[15]
Calcium-activated potassium channel subunit alpha-1 (KCNMA1)	OTNYXOZO	KCMA1_HUMAN	Increases Expression	[15]
Growth factor receptor-bound protein 10 (GRB10)	OTCKXGRC	GRB10_HUMAN	Increases Expression	[15]
Disintegrin and metalloproteinase domain-containing protein 9 (ADAM9)	OT70Z4II	ADAM9_HUMAN	Increases Expression	[15]
Ras GTPase-activating-like protein IQGAP2 (IQGAP2)	OTX2UA7P	IQGA2_HUMAN	Increases Expression	[15]
Dual specificity calcium/calmodulin-dependent 3',5'-cyclic nucleotide phosphodiesterase 1C (PDE1C)	OT5VWYPI	PDE1C_HUMAN	Decreases Expression	[15]
PCNA-associated factor (PCLAF)	OTMVIOUU	PAF15_HUMAN	Decreases Expression	[15]
Kinesin-like protein KIF14 (KIF14)	OTXHT4JM	KIF14_HUMAN	Decreases Expression	[15]
Disks large-associated protein 5 (DLGAP5)	OTWCN39U	DLGP5_HUMAN	Decreases Expression	[15]
Cysteine and glycine-rich protein 2 (CSRP2)	OT4SW0HI	CSRP2_HUMAN	Decreases Expression	[15]
Cyclin-dependent kinase inhibitor 3 (CDKN3)	OTBE3H07	CDKN3_HUMAN	Decreases Expression	[15]
Phosphoenolpyruvate carboxykinase , mitochondrial (PCK2)	OTJ8LX4N	PCKGM_HUMAN	Increases Expression	[15]
Serine protease inhibitor Kazal-type 13 (SPINK13)	OTEU2OSU	ISK13_HUMAN	Increases Expression	[15]
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase eta-1 (PLCH1)	OT6Z1L2E	PLCH1_HUMAN	Decreases Expression	[15]
Centrosomal protein of 55 kDa (CEP55)	OTGSG2PA	CEP55_HUMAN	Decreases Expression	[15]
Shugoshin 2 (SGO2)	OTNGJDS8	SGO2_HUMAN	Decreases Expression	[15]
DEP domain-containing protein 1A (DEPDC1)	OT0JWE1B	DEP1A_HUMAN	Decreases Expression	[15]
Transmembrane protein 164 (TMEM164)	OTSIZY2T	TM164_HUMAN	Increases Expression	[15]
Mesenteric estrogen-dependent adipogenesis protein (MEDAG)	OT6BK4EI	MEDAG_HUMAN	Increases Expression	[15]
Formin-1 (FMN1)	OT9CID5R	FMN1_HUMAN	Decreases Expression	[15]
Pleckstrin homology domain-containing family A member 7 (PLEKHA7)	OTNUMAZ0	PKHA7_HUMAN	Increases Expression	[15]
Potassium channel subfamily T member 2 (KCNT2)	OTFTL0BQ	KCNT2_HUMAN	Increases Expression	[15]
Golgi-associated kinase 1B (GASK1B)	OT2HPHEI	GAK1B_HUMAN	Increases Expression	[15]
NF-X1-type zinc finger protein NFXL1 (NFXL1)	OT2Y5D15	NFXL1_HUMAN	Increases Expression	[15]
Centromere protein U (CENPU)	OTQ4TZRS	CENPU_HUMAN	Decreases Expression	[15]
MAM domain-containing protein 2 (MAMDC2)	OT4GICNY	MAMC2_HUMAN	Increases Expression	[15]
Protein mono-ADP-ribosyltransferase TIPARP (TIPARP)	OTZ4BG4B	PARPT_HUMAN	Increases Expression	[15]
LisH domain-containing protein ARMC9 (ARMC9)	OT0MZER2	ARMC9_HUMAN	Decreases Expression	[15]
Retrotransposon-derived protein PEG10 (PEG10)	OTWD2278	PEG10_HUMAN	Decreases Expression	[15]
Ras GTPase-activating-like protein IQGAP3 (IQGAP3)	OT4RZV2M	IQGA3_HUMAN	Decreases Expression	[15]
Liprin-beta-1 (PPFIBP1)	OTRA2S7B	LIPB1_HUMAN	Decreases Expression	[15]
GAS2-like protein 3 (GAS2L3)	OTWPVI29	GA2L3_HUMAN	Decreases Expression	[15]
Plexin domain-containing protein 1 (PLXDC1)	OT2X0IFQ	PLDX1_HUMAN	Decreases Expression	[15]
Sodium leak channel NALCN (NALCN)	OTWY7DS0	NALCN_HUMAN	Increases Expression	[15]
ATP-binding cassette sub-family A member 6 (ABCA6)	OTJJELUF	ABCA6_HUMAN	Increases Expression	[15]
Dedicator of cytokinesis protein 4 (DOCK4)	OTH3XY8B	DOCK4_HUMAN	Decreases Expression	[15]
Leucine-rich repeat-containing protein 17 (LRRC17)	OT3NZSX3	LRC17_HUMAN	Decreases Expression	[15]
Junction-mediating and -regulatory protein (JMY)	OTH5FFVK	JMY_HUMAN	Decreases Expression	[15]
SHC SH2 domain-binding protein 1 (SHCBP1)	OT3A21CM	SHCBP_HUMAN	Decreases Expression	[15]
Kinetochore scaffold 1 (KNL1)	OT4Q3LHV	KNL1_HUMAN	Decreases Expression	[15]
Pleckstrin homology-like domain family A member 1 (PHLDA1)	OTFTWMIQ	PHLA1_HUMAN	Increases Expression	[15]
Potassium voltage-gated channel subfamily E member 4 (KCNE4)	OTNYW0OL	KCNE4_HUMAN	Increases Expression	[15]
Cytoskeleton-associated protein 2 (CKAP2)	OTCLTC0J	CKAP2_HUMAN	Decreases Expression	[15]
E3 ubiquitin-protein ligase MYLIP (MYLIP)	OTL0PFGV	MYLIP_HUMAN	Decreases Expression	[15]
Phosphatidylinositol 3-kinase regulatory subunit gamma (PIK3R3)	OTXGJ8N1	P55G_HUMAN	Decreases Expression	[15]
Protein NDRG1 (NDRG1)	OTVO66BO	NDRG1_HUMAN	Increases Expression	[15]
Thymic stromal lymphopoietin (TSLP)	OT52AOIG	TSLP_HUMAN	Increases Expression	[15]
Sodium-coupled neutral amino acid transporter 4 (SLC38A4)	OTV5OHBT	S38A4_HUMAN	Decreases Expression	[15]
BTB/POZ domain-containing protein KCTD12 (KCTD12)	OTPYKT4Z	KCD12_HUMAN	Increases Expression	[15]
Terminal nucleotidyltransferase 5A (TENT5A)	OTSYF511	TET5A_HUMAN	Increases Expression	[15]
Beta-galactoside alpha-2,6-sialyltransferase 2 (ST6GAL2)	OTXIBF4D	SIAT2_HUMAN	Decreases Expression	[15]
Lymphokine-activated killer T-cell-originated protein kinase (PBK)	OT5Z27TW	TOPK_HUMAN	Decreases Expression	[15]
FYVE, RhoGEF and PH domain-containing protein 4 (FGD4)	OTYXJQCW	FGD4_HUMAN	Increases Expression	[15]
Sterile alpha motif domain-containing protein 11 (SAMD11)	OT6WRQOX	SAM11_HUMAN	Decreases Expression	[15]
Discoidin, CUB and LCCL domain-containing protein 2 (DCBLD2)	OTB71I02	DCBD2_HUMAN	Decreases Expression	[15]
Hemicentin-1 (HMCN1)	OTLZAS0P	HMCN1_HUMAN	Decreases Expression	[15]
Myeloid-associated differentiation marker (MYADM)	OTZTZI7P	MYADM_HUMAN	Increases Expression	[15]
Cell division cycle-associated protein 3 (CDCA3)	OTUI8QK3	CDCA3_HUMAN	Decreases Expression	[15]
Neuronal PAS domain-containing protein 2 (NPAS2)	OTMRT2TS	NPAS2_HUMAN	Increases Expression	[15]
Condensin complex subunit 3 (NCAPG)	OT1AI9EO	CND3_HUMAN	Decreases Expression	[15]
Potassium voltage-gated channel subfamily S member 3 (KCNS3)	OTHDD9F6	KCNS3_HUMAN	Increases Expression	[15]
Dysbindin domain-containing protein 2 (DBNDD2)	OT9RI580	DBND2_HUMAN	Increases Expression	[15]
Transmembrane protein 204 (TMEM204)	OT7X11D9	TM204_HUMAN	Increases Expression	[15]
Cell division cycle-associated protein 7 (CDCA7)	OT12HDZY	CDCA7_HUMAN	Decreases Expression	[15]
Asporin (ASPN)	OTYJM80N	ASPN_HUMAN	Increases Expression	[15]
Nucleolar and spindle-associated protein 1 (NUSAP1)	OT85HIJ5	NUSAP_HUMAN	Decreases Expression	[15]
Angiopoietin-related protein 4 (ANGPTL4)	OTQL5SPX	ANGL4_HUMAN	Increases Expression	[15]
Lactosylceramide 1,3-N-acetyl-beta-D-glucosaminyltransferase (B3GNT5)	OTA0DE43	B3GN5_HUMAN	Increases Expression	[15]
NF-kappa-B inhibitor zeta (NFKBIZ)	OTU728KS	IKBZ_HUMAN	Increases Expression	[15]
Kinetochore protein Nuf2 (NUF2)	OTOOQL35	NUF2_HUMAN	Decreases Expression	[15]
Small integral membrane protein 3 (SMIM3)	OTWPK14C	SMIM3_HUMAN	Increases Expression	[15]
Transmembrane 6 superfamily member 1 (TM6SF1)	OTQR4I2N	TM6S1_HUMAN	Increases Expression	[15]
Rac GTPase-activating protein 1 (RACGAP1)	OTQE8IEH	RGAP1_HUMAN	Decreases Expression	[15]
Coiled-coil domain-containing protein 68 (CCDC68)	OT4KF6TL	CCD68_HUMAN	Increases Expression	[15]
Tumor protein 63 (TP63)	OT0WOOKQ	P63_HUMAN	Decreases Expression	[15]
Histone-lysine N-methyltransferase SMYD3 (SMYD3)	OT9YR20G	SMYD3_HUMAN	Increases Expression	[15]
Kinesin-like protein KIF13B (KIF13B)	OTAFS1YV	KI13B_HUMAN	Increases Expression	[15]
Anillin (ANLN)	OTXJY54C	ANLN_HUMAN	Decreases Expression	[15]
Matrix-remodeling-associated protein 5 (MXRA5)	OTXZBWCU	MXRA5_HUMAN	Decreases Expression	[15]
Lymphoid-specific helicase (HELLS)	OTVVV668	HELLS_HUMAN	Decreases Expression	[15]
Tumor necrosis factor receptor superfamily member 19 (TNFRSF19)	OTTVT4MB	TNR19_HUMAN	Decreases Expression	[15]
Protein diaphanous homolog 3 (DIAPH3)	OTPOT23F	DIAP3_HUMAN	Decreases Expression	[15]
Structural maintenance of chromosomes protein 4 (SMC4)	OTEJE6AG	SMC4_HUMAN	Decreases Expression	[15]
SERTA domain-containing protein 4 (SERTAD4)	OTZ1GUD9	SRTD4_HUMAN	Decreases Expression	[15]
G2 and S phase-expressed protein 1 (GTSE1)	OTPP742Z	GTSE1_HUMAN	Decreases Expression	[15]
Denticleless protein homolog (DTL)	OTC29RYE	DTL_HUMAN	Decreases Expression	[15]
Contactin-3 (CNTN3)	OTC1274J	CNTN3_HUMAN	Increases Expression	[15]
Prostaglandin F2 receptor negative regulator (PTGFRN)	OTBG4SA2	FPRP_HUMAN	Decreases Expression	[15]
Fibulin-5 (FBLN5)	OTLVNZ8U	FBLN5_HUMAN	Increases Expression	[15]
DNA dC->dU-editing enzyme APOBEC-3B (APOBEC3B)	OTHLNI51	ABC3B_HUMAN	Decreases Expression	[15]
Targeting protein for Xklp2 (TPX2)	OTWLJYH0	TPX2_HUMAN	Decreases Expression	[15]
Dynamin-3 (DNM3)	OTDMUGCR	DYN3_HUMAN	Decreases Expression	[15]
Nuclear protein AMMECR1 (AMMECR1)	OTWMQ67T	AMMR1_HUMAN	Increases Expression	[15]
Fatty acid desaturase 3 (FADS3)	OT9RVXGE	FADS3_HUMAN	Increases Expression	[15]
Calcium-activated potassium channel subunit beta-2 (KCNMB2)	OTBXUQGK	KCMB2_HUMAN	Decreases Expression	[15]
Sulfide:quinone oxidoreductase, mitochondrial (SQOR)	OTTLD0KB	SQOR_HUMAN	Increases Expression	[15]
Diacylglycerol kinase beta (DGKB)	OTTT9SZJ	DGKB_HUMAN	Decreases Expression	[15]
Influenza virus NS1A-binding protein (IVNS1ABP)	OTYHL4I7	NS1BP_HUMAN	Decreases Expression	[15]
Aromatase (CYP19A1)	OTZ6XF74	CP19A_HUMAN	Decreases Expression	[62]
Prostaglandin G/H synthase 2 (PTGS2)	OT75U9M4	PGH2_HUMAN	Decreases Expression	[62]
Sulfotransferase 1E1 (SULT1E1)	OTGPJ517	ST1E1_HUMAN	Increases Expression	[63]
Cytochrome P450 2C8 (CYP2C8)	OTHCWT42	CP2C8_HUMAN	Increases Expression	[43]
Cytochrome P450 2B6 (CYP2B6)	OTOYO4S7	CP2B6_HUMAN	Increases Expression	[43]
3-oxo-5-alpha-steroid 4-dehydrogenase 1 (SRD5A1)	OTQRET2B	S5A1_HUMAN	Decreases Expression	[44]
17-beta-hydroxysteroid dehydrogenase type 2 (HSD17B2)	OT3K7HY5	DHB2_HUMAN	Decreases Expression	[44]
Aldo-keto reductase family 1 member C3 (AKR1C3)	OTU2SXBA	AK1C3_HUMAN	Decreases Expression	[44]
Bile salt export pump (ABCB11)	OTRU7THO	ABCBB_HUMAN	Decreases Activity	[64]
Toll-like receptor 4 (TLR4)	OTP7ML3S	TLR4_HUMAN	Increases Expression	[65]
Basic helix-loop-helix ARNT-like protein 1 (BMAL1)	OTMI12L2	BMAL1_HUMAN	Increases Expression	[66]
Gamma-aminobutyric acid receptor subunit pi (GABRP)	OTGKA8WS	GBRP_HUMAN	Increases Expression	[67]
Suppressor of cytokine signaling 2 (SOCS2)	OTBPNKJQ	SOCS2_HUMAN	Decreases Expression	[68]
Suppressor of cytokine signaling 3 (SOCS3)	OTY183WJ	SOCS3_HUMAN	Increases Expression	[68]
C-X-C motif chemokine 11 (CXCL11)	OT353XE3	CXL11_HUMAN	Increases Expression	[69]
Interferon-induced protein with tetratricopeptide repeats 3 (IFIT3)	OTPGHZB9	IFIT3_HUMAN	Increases Expression	[68]
Period circadian protein homolog 2 (PER2)	OTU2B1DJ	PER2_HUMAN	Increases Expression	[66]
Defensin beta 4A (DEFB4A)	OTQEI15K	DFB4A_HUMAN	Increases Expression	[70]
Suppressor of cytokine signaling 1 (SOCS1)	OTWA9KFU	SOCS1_HUMAN	Decreases Expression	[68]
Interleukin-1 receptor-associated kinase-like 2 (IRAK2)	OT6Y1QZN	IRAK2_HUMAN	Increases Expression	[65]
Left-right determination factor 1 (LEFTY1)	OT51HVC4	LFTY1_HUMAN	Increases Expression	[71]
Stanniocalcin-2 (STC2)	OT86YP8G	STC2_HUMAN	Decreases Expression	[72]
Dickkopf-related protein 1 (DKK1)	OTRDLUSP	DKK1_HUMAN	Increases Expression	[73]
Serine protease 23 (PRSS23)	OT6DQAM1	PRS23_HUMAN	Decreases Expression	[74]
Neuroendocrine secretory protein 55 (GNAS)	OTMH8BKJ	GNAS3_HUMAN	Increases Expression	[75]
C-X-C motif chemokine 14 (CXCL14)	OTM189TA	CXL14_HUMAN	Increases Expression	[76]
Epidermal growth factor receptor (EGFR)	OTAPLO1S	EGFR_HUMAN	Increases Expression	[77]
Prothrombin (F2)	OTNFSM49	THRB_HUMAN	Increases Expression	[78]
2'-5'-oligoadenylate synthase 1 (OAS1)	OT8ZLOCY	OAS1_HUMAN	Increases Expression	[68]
Antithrombin-III (SERPINC1)	OTDFATG0	ANT3_HUMAN	Decreases Expression	[78]
Metalloproteinase inhibitor 1 (TIMP1)	OTOXC51H	TIMP1_HUMAN	Increases Expression	[79]
Transforming growth factor beta-1 proprotein (TGFB1)	OTV5XHVH	TGFB1_HUMAN	Decreases Expression	[80]
Prolactin (PRL)	OTWFQGX7	PRL_HUMAN	Increases Expression	[81]
Somatotropin (GH1)	OT92RTRD	SOMA_HUMAN	Increases Secretion	[82]
Tumor necrosis factor (TNF)	OT4IE164	TNFA_HUMAN	Decreases Expression	[83]
Interferon alpha-2 (IFNA2)	OT4GII73	IFNA2_HUMAN	Increases Expression	[83]
Interleukin-1 beta (IL1B)	OT0DWXXB	IL1B_HUMAN	Decreases Expression	[83]
C-X-C motif chemokine 10 (CXCL10)	OTTLQ6S0	CXL10_HUMAN	Increases Expression	[69]
RAF proto-oncogene serine/threonine-protein kinase (RAF1)	OT51LSFO	RAF1_HUMAN	Decreases Phosphorylation	[48]
Platelet-derived growth factor subunit A (PDGFA)	OTCMZ0W8	PDGFA_HUMAN	Increases Expression	[84]
Glucocorticoid receptor (NR3C1)	OTCI2YDI	GCR_HUMAN	Increases Expression	[85]
Sex hormone-binding globulin (SHBG)	OTPWU5IW	SHBG_HUMAN	Affects Binding	[86]
Cellular tumor antigen p53 (TP53)	OTIE1VH3	P53_HUMAN	Increases Expression	[87]
Interleukin-4 (IL4)	OTOXBWAU	IL4_HUMAN	Increases Expression	[83]
Tetranectin (CLEC3B)	OTFD29NF	TETN_HUMAN	Increases Expression	[79]
Pulmonary surfactant-associated protein B (SFTPB)	OTOHS07E	PSPB_HUMAN	Increases Expression	[88]
Mineralocorticoid receptor (NR3C2)	OT0F2V2Z	MCR_HUMAN	Increases Activity	[89]
Stromelysin-1 (MMP3)	OTGBI74Z	MMP3_HUMAN	Decreases Expression	[71]
Integrin alpha-5 (ITGA5)	OT3RCI67	ITA5_HUMAN	Increases Expression	[79]
Guanine nucleotide-binding protein G(i) subunit alpha-3 (GNAI3)	OT89UWAR	GNAI3_HUMAN	Decreases Expression	[75]
Interleukin-6 receptor subunit alpha (IL6R)	OTCQL07Z	IL6RA_HUMAN	Decreases Expression	[68]
Matrilysin (MMP7)	OTVT3SEJ	MMP7_HUMAN	Decreases Secretion	[90]
Stromelysin-2 (MMP10)	OTJDWW8Q	MMP10_HUMAN	Increases Expression	[79]
Growth-regulated alpha protein (CXCL1)	OT3WCTZV	GROA_HUMAN	Decreases Expression	[83]
Myb-related protein A (MYBL1)	OTBJMC2P	MYBA_HUMAN	Increases Expression	[91]
Androgen receptor (AR)	OTUBKAZZ	ANDR_HUMAN	Decreases Expression	[18]
Solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1)	OTA675TJ	GTR1_HUMAN	Increases Expression	[92]
Steroid hormone receptor ERR1 (ESRRA)	OTTDTUSP	ERR1_HUMAN	Increases Expression	[93]
Bone morphogenetic protein 2 (BMP2)	OT23T37S	BMP2_HUMAN	Decreases Expression	[72]
C-C motif chemokine 5 (CCL5)	OTSCA5CK	CCL5_HUMAN	Increases Expression	[68]
Cystic fibrosis transmembrane conductance regulator (CFTR)	OT6B22QH	CFTR_HUMAN	Decreases Expression	[94]
Tissue factor (F3)	OT3MSU3B	TF_HUMAN	Increases Expression	[95]
HLA class I histocompatibility antigen, alpha chain E (HLA-E)	OTX1CTFB	HLAE_HUMAN	Increases Expression	[96]
Matrix metalloproteinase-9 (MMP9)	OTB2QDAV	MMP9_HUMAN	Increases Expression	[79]
Mucin-1 (MUC1)	OTHQI7IY	MUC1_HUMAN	Affects Expression	[97]
Aggrecan core protein (ACAN)	OTUOCW8K	PGCA_HUMAN	Increases Expression	[98]
Integrin beta-4 (ITGB4)	OT28UK84	ITB4_HUMAN	Increases Expression	[79]
Prolactin receptor (PRLR)	OTTHN46W	PRLR_HUMAN	Decreases Expression	[18]
HLA class I histocompatibility antigen, alpha chain G (HLA-G)	OTMLK1KN	HLAG_HUMAN	Increases Expression	[99]
Bone morphogenetic protein 7 (BMP7)	OTYATP2K	BMP7_HUMAN	Decreases Expression	[100]
Cyclic AMP-dependent transcription factor ATF-3 (ATF3)	OTC1UOHP	ATF3_HUMAN	Increases Expression	[101]
C-X-C motif chemokine 2 (CXCL2)	OTEJCYMY	CXCL2_HUMAN	Decreases Expression	[83]
Interleukin-10 (IL10)	OTIRFRXC	IL10_HUMAN	Increases Expression	[83]
Nucleoside diphosphate kinase B (NME2)	OTCYGLHV	NDKB_HUMAN	Increases Expression	[101]
Potassium voltage-gated channel subfamily A member 5 (KCNA5)	OTHI2N71	KCNA5_HUMAN	Decreases Activity	[102]
Fibulin-1 (FBLN1)	OT5MHHOP	FBLN1_HUMAN	Increases Expression	[103]
Cyclin-dependent kinase 2 (CDK2)	OTB5DYYZ	CDK2_HUMAN	Decreases Activity	[87]
Integrin alpha-3 (ITGA3)	OTBCH21D	ITA3_HUMAN	Increases Expression	[79]
Integrin beta-8 (ITGB8)	OTP4HSHG	ITB8_HUMAN	Affects Expression	[17]
Calreticulin (CALR)	OTYD2TR1	CALR_HUMAN	Decreases Expression	[104]
ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase 1 (CD38)	OTG0TTX7	CD38_HUMAN	Increases Expression	[68]
HLA class I histocompatibility antigen, alpha chain F (HLA-F)	OT76CM19	HLAF_HUMAN	Increases Expression	[96]
Neuronal acetylcholine receptor subunit alpha-5 (CHRNA5)	OTGIL2YD	ACHA5_HUMAN	Increases Expression	[105]
Gamma-aminobutyric acid receptor subunit alpha-5 (GABRA5)	OTBIKWQT	GBRA5_HUMAN	Decreases Expression	[106]
Corticotropin-releasing factor receptor 1 (CRHR1)	OT5PWHAI	CRFR1_HUMAN	Increases Expression	[107]
Insulin receptor substrate 1 (IRS1)	OTNO82CU	IRS1_HUMAN	Decreases Phosphorylation	[108]
Metalloproteinase inhibitor 3 (TIMP3)	OTDGQAD1	TIMP3_HUMAN	Decreases Expression	[71]
Protein DEK (DEK)	OTYCJ5H6	DEK_HUMAN	Increases Expression	[109]
Cyclin-dependent kinase inhibitor 1 (CDKN1A)	OTQWHCZE	CDN1A_HUMAN	Increases Expression	[87]
Collagen alpha-1(XV) chain (COL15A1)	OTTFKK18	COFA1_HUMAN	Increases Expression	[79]
Leptin (LEP)	OT5Q7ODW	LEP_HUMAN	Decreases Secretion	[110]
B-cell lymphoma 6 protein (BCL6)	OTQAWWO1	BCL6_HUMAN	Increases Expression	[18]
Signal transducer and activator of transcription 5A (STAT5A)	OTBSJGN3	STA5A_HUMAN	Increases Expression	[77]
Serine/threonine-protein kinase mTOR (MTOR)	OTHH8KU7	MTOR_HUMAN	Decreases Expression	[111]
Caspase-3 (CASP3)	OTIJRBE7	CASP3_HUMAN	Increases Activity	[112]
Megakaryocyte-associated tyrosine-protein kinase (MATK)	OTVOJJLJ	MATK_HUMAN	Increases Expression	[48]
Proliferation marker protein Ki-67 (MKI67)	OTA8N1QI	KI67_HUMAN	Increases Expression	[84]
Cyclin-dependent kinase inhibitor 1B (CDKN1B)	OTNY5LLZ	CDN1B_HUMAN	Increases Expression	[87]
Gamma-aminobutyric acid receptor subunit alpha-2 (GABRA2)	OT9TZ2E0	GBRA2_HUMAN	Increases Expression	[106]
Cyclin-dependent kinase 8 (CDK8)	OTMC3CWX	CDK8_HUMAN	Increases Expression	[84]
Glycogen synthase kinase-3 beta (GSK3B)	OTL3L14B	GSK3B_HUMAN	Increases Phosphorylation	[113]
Cathelicidin antimicrobial peptide (CAMP)	OT3Y8011	CAMP_HUMAN	Increases Expression	[65]
Cyclin-dependent kinase 9 (CDK9)	OT2B7OGB	CDK9_HUMAN	Increases Expression	[84]
Matrix metalloproteinase-16 (MMP16)	OTSFQ2BJ	MMP16_HUMAN	Decreases Expression	[79]
Interleukin-1 receptor-associated kinase 1 (IRAK1)	OT133G8J	IRAK1_HUMAN	Increases Expression	[65]
Signal transducer and activator of transcription 5B (STAT5B)	OTZVPEBT	STA5B_HUMAN	Increases Expression	[77]
Neutrophil defensin 1 (DEFA1)	OT5N1B9B	DEF1_HUMAN	Increases Expression	[65]
Neutrophil defensin 3 (DEFA3)	OTO3N8E1	DEF3_HUMAN	Increases Expression	[65]
Histone H4 (H4C1)	OTB71W46	H4_HUMAN	Increases Expression	[84]
Tumor necrosis factor-inducible gene 6 protein (TNFAIP6)	OT1SLUZH	TSG6_HUMAN	Decreases Expression	[72]
Caveolin-1 (CAV1)	OTEZUR1L	CAV1_HUMAN	Increases Expression	[101]
Transcription factor p65 (RELA)	OTUJP9CN	TF65_HUMAN	Decreases Activity	[83]
Lymphotoxin-beta (LTB)	OTUFS8CF	TNFC_HUMAN	Increases Expression	[83]
Semaphorin-3B (SEMA3B)	OTCZCPMS	SEM3B_HUMAN	Increases Expression	[112]
Pappalysin-1 (PAPPA)	OTTTG9PG	PAPP1_HUMAN	Decreases Expression	[74]
Semaphorin-3F (SEMA3F)	OTQFMS8S	SEM3F_HUMAN	Increases Expression	[112]
Metastasis-associated protein MTA1 (MTA1)	OTBHW3S9	MTA1_HUMAN	Increases Expression	[84]
28 kDa heat- and acid-stable phosphoprotein (PDAP1)	OTJSWMOD	HAP28_HUMAN	Increases Expression	[84]
Laminin subunit beta-3 (LAMB3)	OTFPU6W8	LAMB3_HUMAN	Increases Expression	[79]
Interleukin-27 subunit beta (EBI3)	OT0LF3D7	IL27B_HUMAN	Increases Expression	[68]
Hypermethylated in cancer 1 protein (HIC1)	OTI9TWY4	HIC1_HUMAN	Increases Expression	[68]
Interleukin-13 receptor subunit alpha-2 (IL13RA2)	OTPC2G0X	I13R2_HUMAN	Decreases Expression	[72]
Sonic hedgehog protein (SHH)	OTOG2BXF	SHH_HUMAN	Decreases Expression	[72]
Rapamycin-insensitive companion of mTOR (RICTOR)	OTCC58QJ	RICTR_HUMAN	Decreases Expression	[111]
Thrombospondin type-1 domain-containing protein 4 (THSD4)	OTXDBMDC	THSD4_HUMAN	Increases Expression	[74]
Cytochrome P450 4Z1 (CYP4Z1)	OTKRGJBG	CP4Z1_HUMAN	Increases Expression	[114]
Organic anion transporter 7 (SLC22A9)	OTO4BJCC	S22A9_HUMAN	Decreases Activity	[115]
E3 ubiquitin-protein ligase TRIM22 (TRIM22)	OTJBLG5R	TRI22_HUMAN	Increases Expression	[116]
Regulatory-associated protein of mTOR (RPTOR)	OT4TQZ9F	RPTOR_HUMAN	Decreases Expression	[111]
DEP domain-containing mTOR-interacting protein (DEPTOR)	OTCBP1BT	DPTOR_HUMAN	Decreases Expression	[111]
Progesterone-induced-blocking factor 1 (PIBF1)	OTCBT1A1	PIBF1_HUMAN	Increases Expression	[65]
Estrogen receptor beta (ESR2)	OTXNR2WQ	ESR2_HUMAN	Increases Expression	[117]
Adiponectin receptor protein 1 (ADIPOR1)	OT65ZFZN	PAQR1_HUMAN	Increases Expression	[118]
Ankyrin repeat and SOCS box protein 2 (ASB2)	OTF9LV7L	ASB2_HUMAN	Increases Expression	[68]
Rho GTPase-activating protein 7 (DLC1)	OTP8LMCR	RHG07_HUMAN	Increases Expression	[101]
Zinc finger protein Gfi-1 (GFI1)	OT9HB9H8	GFI1_HUMAN	Increases Expression	[68]
Gamma-aminobutyric acid receptor subunit gamma-3 (GABRG3)	OTNWVXZR	GBRG3_HUMAN	Increases Expression	[106]
Leucine zipper transcription factor-like protein 1 (LZTFL1)	OTIEIOEW	LZTL1_HUMAN	Increases Expression	[68]
Interleukin-17 receptor B (IL17RB)	OT0KDNSF	I17RB_HUMAN	Decreases Expression	[74]
Protein DEPP1 (DEPP1)	OTB36PHJ	DEPP1_HUMAN	Increases Expression	[119]
Interleukin-1 receptor-associated kinase 4 (IRAK4)	OT9JTJWC	IRAK4_HUMAN	Increases Expression	[65]
Toll-like receptor 7 (TLR7)	OT3HZV7Z	TLR7_HUMAN	Increases Expression	[65]
Dickkopf-related protein 3 (DKK3)	OTDU94EY	DKK3_HUMAN	Decreases Expression	[74]
A disintegrin and metalloproteinase with thrombospondin motifs 1 (ADAMTS1)	OTTLJH8W	ATS1_HUMAN	Increases Expression	[120]
Syncytin-1 (ERVW-1)	OTWV8DXJ	SYCY1_HUMAN	Increases Expression	[121]
Tumor necrosis factor ligand superfamily member 13B (TNFSF13B)	OTND26XR	TN13B_HUMAN	Increases Expression	[68]
Insulin receptor substrate 2 (IRS2)	OT46MJBE	IRS2_HUMAN	Increases Expression	[108]
Glycoprotein hormones alpha chain (CGA)	OT00U3Y3	GLHA_HUMAN	Increases Secretion	[122]
Pituitary adenylate cyclase-activating polypeptide (ADCYAP1)	OT0LQH93	PACA_HUMAN	Increases Abundance	[22]
Corticoliberin (CRH)	OT2MOC4T	CRF_HUMAN	Decreases Abundance	[123]
Cholesterol side-chain cleavage enzyme, mitochondrial (CYP11A1)	OT2NV3AN	CP11A_HUMAN	Affects Abundance	[124]
L-fucose kinase (FCSK)	OT4NTHYO	FCSK_HUMAN	Affects Response To Substance	[20]
Lutropin subunit beta (LHB)	OT5GBOVJ	LSHB_HUMAN	Decreases Abundance	[125]
Protein kinase C alpha type (PRKCA)	OT5UWNRD	KPCA_HUMAN	Increases ADR	[21]
Aldo-keto reductase family 1 member D1 (AKR1D1)	OTBDJ6RL	AK1D1_HUMAN	Increases Reduction	[126]
Follitropin subunit beta (FSHB)	OTGLS283	FSHB_HUMAN	Increases Abundance	[127]
Glutathione S-transferase A3 (GSTA3)	OTJ3REE3	GSTA3_HUMAN	Increases Chemical Synthesis	[42]
3 beta-hydroxysteroid dehydrogenase/Delta 5-->4-isomerase type 1 (HSD3B1)	OTNAZVKB	3BHS1_HUMAN	Increases Chemical Synthesis	[128]
Corticosteroid-binding globulin (SERPINA6)	OTOIBEW7	CBG_HUMAN	Increases Transport	[129]
Steroidogenic factor 1 (NR5A1)	OTOULYR4	STF1_HUMAN	Increases Abundance	[130]
Aldo-keto reductase family 1 member C2 (AKR1C2)	OTQ2XMO3	AK1C2_HUMAN	Increases Reduction	[131]
Glycodelin (PAEP)	OTQA0NV4	PAEP_HUMAN	Increases Abundance	[132]
High affinity cationic amino acid transporter 1 (SLC7A1)	OTR2ZVA8	CTR1_HUMAN	Increases ADR	[21]
Retinol-binding protein 1 (RBP1)	OTRP1MFC	RET1_HUMAN	Increases ADR	[21]
Lutropin-choriogonadotropic hormone receptor (LHCGR)	OTSVIJ6I	LSHR_HUMAN	Increases ADR	[21]
Carboxypeptidase Q (CPQ)	OTTNZNLD	CBPQ_HUMAN	Affects Response To Substance	[20]
Pro-opiomelanocortin (POMC)	OTV41F7T	COLI_HUMAN	Increases Abundance	[133]
Choriogonadotropin subunit beta 3 (CGB3)	OTVM2SU3	CGB3_HUMAN	Increases Abundance	[134]
Aldo-keto reductase family 1 member C4 (AKR1C4)	OTW2MMOF	AK1C4_HUMAN	Decreases Abundance	[135]
Testis-expressed protein 12 (TEX12)	OTXHQWTA	TEX12_HUMAN	Affects Response To Substance	[20]
Liprin-beta-2 (PPFIBP2)	OTXQO55Y	LIPB2_HUMAN	Affects Response To Substance	[20]
Polypeptide N-acetylgalactosaminyltransferase 10 (GALNT10)	OTZ6FDOL	GLT10_HUMAN	Affects Response To Substance	[20]
Catenin beta-1 (CTNNB1)	OTZ932A3	CTNB1_HUMAN	Increases ADR	[21]
Steroid 17-alpha-hydroxylase/17,20 lyase (CYP17A1)	OTZKVLVJ	CP17A_HUMAN	Increases Hydroxylation	[136]

Indication(s) of Estetrol

Disease Entry	ICD 11	Status	REF
Autoimmune diabetes	5A10	Phase 2	[7]

Estetrol Interacts with 1 DTT Molecule(s)

DTT Name	DTT ID	UniProt ID	Mode of Action	REF
Estrogen receptor (ESR)	TTZAYWL	ESR1_HUMAN	Modulator	[137]

References

• [1] ClinicalTrials.gov (NCT04209543) Estetrol for the Treatment of Moderate to Severe Vasomotor Symptoms in Postmenopausal Women (E4Comfort Study I)
• [2] FDA Approved Drug Products from FDA Official Website. 2019. Application Number: (ANDA) 075906.
• [3] Progesterone FDA Label
• [4] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2377).
• [5] ClinicalTrials.gov (NCT00822900) Progesterone for the Treatment of Traumatic Brain Injury III. U.S. National Institutes of Health.
• [6] ClinicalTrials.gov (NCT04365127) Progesterone for the Treatment of COVID-19 in Hospitalized Men. U.S. National Institutes of Health.
• [7] ClinicalTrials.gov (NCT00563472) Feasibility Study Into the Contraceptive Effect of Estetrol. U.S. National Institutes of Health.
• [8] Progesterone regulation of implantation-related genes: new insights into the role of oestrogen. Cell Mol Life Sci. 2007 Apr;64(7-8):1009-32.
• [9] Gene expression in endometrial cancer cells (Ishikawa) after short time high dose exposure to progesterone. Steroids. 2008 Jan;73(1):116-28.
• [10] Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: implications for pathogenesis of ovarian cancer. BMC Cancer. 2007 Dec 11;7:223.
• [11] Progestins regulate genes that can elicit both proliferative and antiproliferative effects in breast cancer cells. Oncol Rep. 2008 Jun;19(6):1627-34.
• [12] Effect of ovarian steroids on gene expression profile in human uterine microvascular endothelial cells. Fertil Steril. 2009 Aug;92(2):709-21.
• [13] Unique transcriptome, pathways, and networks in the human endometrial fibroblast response to progesterone in endometriosis. Biol Reprod. 2011 Apr;84(4):801-15.
• [14] Endometrial receptivity is affected in women with high circulating progesterone levels at the end of the follicular phase: a functional genomics analysis. Hum Reprod. 2011 Jul;26(7):1813-25.
• [15] Effects of progesterone treatment on expression of genes involved in uterine quiescence. Reprod Sci. 2011 Aug;18(8):781-97.
• [16] The bradykinin-degrading aminopeptidase P is increased in women taking the oral contraceptive pill. J Renin Angiotensin Aldosterone Syst. 2008 Dec;9(4):221-5. doi: 10.1177/1470320308096405.
• [17] Perfluorooctanoic acid alters progesterone activity in human endometrial cells and induces reproductive alterations in young women. Chemosphere. 2020 Mar;242:125208. doi: 10.1016/j.chemosphere.2019.125208. Epub 2019 Oct 24.
• [18] Expression of estrogen-, progesterone-, and androgen-responsive genes in MCF-7 and MDA-MB-231 cells treated with o,p'-DDT, p,p'-DDT, or endosulfan. J Biochem Mol Toxicol. 2021 Jun;35(6):1-8. doi: 10.1002/jbt.22773. Epub 2021 Mar 16.
• [19] Progesterone up-regulates WT1 mRNA and protein, and alters the relative expression of WT1 transcripts in cultured endometrial stromal cells. J Soc Gynecol Investig. 2003 Dec;10(8):509-16. doi: 10.1016/s1071-5576(03)00147-3.
• [20] Population-based in vitro hazard and concentration-response assessment of chemicals: the 1000 genomes high-throughput screening study. Environ Health Perspect. 2015 May;123(5):458-66. doi: 10.1289/ehp.1408775. Epub 2015 Jan 13.
• [21] ADReCS-Target: target profiles for aiding drug safety research and application. Nucleic Acids Res. 2018 Jan 4;46(D1):D911-D917. doi: 10.1093/nar/gkx899.
• [22] Luteinizing hormone-stimulated pituitary adenylate cyclase-activating polypeptide system and its role in progesterone production in human luteinized granulosa cells. Endocr J. 2010;57(2):127-34. doi: 10.1507/endocrj.k09e-077. Epub 2009 Nov 19.
• [23] Clinical pipeline report, company report or official report of lipocine.
• [24] Comparative studies on in vitro methods for evaluating in vivo function of MDR1 P-glycoprotein. Pharm Res. 2001 Dec;18(12):1660-8.
• [25] Sterol transport by the human breast cancer resistance protein (ABCG2) expressed in Lactococcus lactis. J Biol Chem. 2003 Jun 6;278(23):20645-51.
• [26] Contribution of human hepatic cytochrome P450 isoforms to regioselective hydroxylation of steroid hormones. Xenobiotica. 1998 Jun;28(6):539-47.
• [27] Summary of information on human CYP enzymes: human P450 metabolism data. Drug Metab Rev. 2002 Feb-May;34(1-2):83-448.
• [28] Allelic variants of human cytochrome P450 1A1 (CYP1A1): effect of T461N and I462V substitutions on steroid hydroxylase specificity. Pharmacogenetics. 2000 Aug;10(6):519-30.
• [29] Progestagenic effects of tibolone are target gene-specific in human endometrial cells. J Soc Gynecol Investig. 2006 Sep;13(6):459-65.
• [30] Effect of genetic polymorphism on the metabolism of endogenous neuroactive substances, progesterone and p-tyramine, catalyzed by CYP2D6. Brain Res Mol Brain Res. 2004 Oct 22;129(1-2):117-23.
• [31] Steroid hormone hydroxylase specificities of eleven cDNA-expressed human cytochrome P450s. Arch Biochem Biophys. 1991 Oct;290(1):160-6.
• [32] Human glutathione transferase A3-3, a highly efficient catalyst of double-bond isomerization in the biosynthetic pathway of steroid hormones. J Biol Chem. 2001 Aug 31;276(35):33061-5.
• [33] Human prostate CYP3A5: identification of a unique 5'-untranslated sequence and characterization of purified recombinant protein. Biochem Biophys Res Commun. 1999 Jul 14;260(3):676-81.
• [34] The role of cytochrome P450 3A (CYP3A) isoform(s) in oxidative metabolism of testosterone and benzphetamine in human adult and fetal liver. J Steroid Biochem Mol Biol. 1993 Jan;44(1):61-7.
• [35] Progesterone and testosterone hydroxylation by cytochromes P450 2C19, 2C9, and 3A4 in human liver microsomes. Arch Biochem Biophys. 1997 Oct 1;346(1):161-9.
• [36] Catalytic properties of polymorphic human cytochrome P450 1B1 variants. Carcinogenesis. 1999 Aug;20(8):1607-13.
• [37] Broad substrate specificity of human cytochrome P450 46A1 which initiates cholesterol degradation in the brain. Biochemistry. 2003 Dec 9;42(48):14284-92.
• [38] Human cytochrome P450 21A2, the major steroid 21-hydroxylase: structure of the enzyme progesterone substrate complex and rate-limiting C-H bond cleavage. J Biol Chem. 2015 May 22;290(21):13128-43.
• [39] Human 3-alpha hydroxysteroid dehydrogenase type 3 (3alpha-HSD3): the V54L mutation restricting the steroid alternative binding and enhancing the 20alpha-HSD activity. J Steroid Biochem Mol Biol. 2014 May;141:135-43.
• [40] Engineering of CYP106A2 for steroid 9alpha- and 6beta-hydroxylation. Steroids. 2017 Apr;120:41-48.
• [41] acillus megaterium SF185 spores exert protective effects against oxidative stress in vivo and in vitro. Sci Rep. 2019 Aug 19;9(1):12082.
• [42] Human glutathione S-transferase A (GSTA) family genes are regulated by steroidogenic factor 1 (SF-1) and are involved in steroidogenesis. FASEB J. 2013 Aug;27(8):3198-208. doi: 10.1096/fj.12-222745. Epub 2013 May 6.
• [43] Isoform-specific regulation of cytochromes P450 expression by estradiol and progesterone. Drug Metab Dispos. 2013 Feb;41(2):263-9.
• [44] Progestin effects on expression of AKR1C1-AKR1C3, SRD5A1 and PGR in the Z-12 endometriotic epithelial cell line. Chem Biol Interact. 2013 Feb 25;202(1-3):218-25.
• [45] Extraadrenal 21-hydroxylation by CYP2C19 and CYP3A4: effect on 21-hydroxylase deficiency. J Clin Endocrinol Metab. 2009 Jan;94(1):89-95. doi: 10.1210/jc.2008-1174. Epub 2008 Oct 28.
• [46] Localization of breast cancer resistance protein (Bcrp) in endocrine organs and inhibition of its transport activity by steroid hormones. Cell Tissue Res. 2012 Aug;349(2):551-63. doi: 10.1007/s00441-012-1417-5. Epub 2012 May 13.
• [47] P-glycoprotein (P-gp/MDR1)-mediated efflux of sex-steroid hormones and modulation of P-gp expression in vitro. Pharm Res. 2004 Jul;21(7):1284-93.
• [48] Progesterone increases csk homologous kinase in HMC-1560 human mast cells and reduces cell proliferation. J Cell Biochem. 2007 Dec 1;102(5):1271-80. doi: 10.1002/jcb.21357.
• [49] Steroid profiling in H295R cells to identify chemicals potentially disrupting the production of adrenal steroids. Toxicology. 2017 Apr 15;381:51-63.
• [50] Hecate-CGbeta conjugate and gonadotropin suppression shows two distinct mechanisms of action in the treatment of adrenocortical tumors in transgenic mice expressing Simian Virus 40 T antigen under inhibin-alpha promoter. Endocr Relat Cancer. 2009 Jun;16(2):549-64. doi: 10.1677/ERC-08-0232. Epub 2009 Mar 4.
• [51] ECC-1 human endometrial cells as a model system to study dioxin disruption of steroid hormone function. In Vitro Cell Dev Biol Anim. 1999 Apr;35(4):183-9.
• [52] Expression and pharmacological profile of the human organic cation transporters hOCT1, hOCT2 and hOCT3. Br J Pharmacol. 2002 Jul;136(6):829-36.
• [53] Differential signal transduction of progesterone and medroxyprogesterone acetate in human endothelial cells. Endocrinology. 2004 Dec;145(12):5745-56.
• [54] The pregnane X receptor regulates gene expression in a ligand- and promoter-selective fashion. Mol Endocrinol. 2005 May;19(5):1170-80.
• [55] Interaction of progestins with the human multidrug resistance-associated protein 2 (MRP2). Drug Metab Dispos. 2005 Nov;33(11):1576-9.
• [56] Further insights into the regulation of human FAAH by progesterone and leptin implications for endogenous levels of anandamide and apoptosis of immune and neuronal cells. Neurotoxicology. 2005 Oct;26(5):811-7.
• [57] Regulation of catechol-O-methyltransferase expression in human myometrial cells. Obstet Gynecol. 2006 Dec;108(6):1439-47.
• [58] Effect of the interaction between lipoxygenase pathway and progesterone on the regulation of hydroxysteroid 11-Beta dehydrogenase 2 in cultured human term placental trophoblasts. Biol Reprod. 2008 Mar;78(3):514-20.
• [59] Influence of progesterone on endometrial nitric oxide synthase expression. Fertil Steril. 2009 May;91(5 Suppl):2157-62.
• [60] Molecular interactions of progesterone derivatives with 5 alpha-reductase types 1 and 2 and androgen receptors. Steroids. 2010 Jul;75(7):499-505.
• [61] Effect of prolonged in vivo administration of progesterone in pregnancy on myometrial gene expression, peripheral blood leukocyte activation, and circulating steroid hormone levels. Reprod Sci. 2011 May;18(5):435-46.
• [62] Dienogest inhibits aromatase and cyclooxygenase-2 expression and prostaglandin E?production in human endometriotic stromal cells in spheroid culture. Fertil Steril. 2012 Feb;97(2):477-82.
• [63] Potential hazards to embryo implantation: A human endometrial in vitro model to identify unwanted antigestagenic actions of chemicals. Toxicol Appl Pharmacol. 2012 May 1;260(3):232-40.
• [64] Early identification of clinically relevant drug interactions with the human bile salt export pump (BSEP/ABCB11). Toxicol Sci. 2013 Dec;136(2):328-43.
• [65] Expression and modulation of progesterone induced blocking factor (PIBF) and innate immune factors in human leukemia cell lines by progesterone and mifepristone. Leuk Lymphoma. 2007 Aug;48(8):1610-7. doi: 10.1080/10428190701471999.
• [66] Influence of the estrous cycle on clock gene expression in reproductive tissues: effects of fluctuating ovarian steroid hormone levels. Steroids. 2010 Mar;75(3):203-12. doi: 10.1016/j.steroids.2010.01.007. Epub 2010 Jan 22.
• [67] HOXA10 regulates endometrial GABAA {pi} receptor expression and membrane translocation. Am J Physiol Endocrinol Metab. 2010 Apr;298(4):E889-93. doi: 10.1152/ajpendo.00577.2009. Epub 2010 Jan 26.
• [68] Progesterone promotes differentiation of human cord blood fetal T cells into T regulatory cells but suppresses their differentiation into Th17 cells. J Immunol. 2011 Aug 15;187(4):1778-87. doi: 10.4049/jimmunol.1003919. Epub 2011 Jul 18.
• [69] Recruitment of uterine NK cells: induction of CXC chemokine ligands 10 and 11 in human endometrium by estradiol and progesterone. J Immunol. 2004 Dec 1;173(11):6760-6. doi: 10.4049/jimmunol.173.11.6760.
• [70] Modulation of human beta-defensin-2 expression by 17beta-estradiol and progesterone in vaginal epithelial cells. Cytokine. 2010 Feb;49(2):209-14. doi: 10.1016/j.cyto.2009.09.005. Epub 2009 Oct 9.
• [71] Triclosan and bisphenol a affect decidualization of human endometrial stromal cells. Mol Cell Endocrinol. 2016 Feb 15;422:74-83. doi: 10.1016/j.mce.2015.11.017. Epub 2015 Nov 19.
• [72] Ovarian steroids, mitogen-activated protein kinases, and/or aspartic proteinases cooperate to control endometrial remodeling by regulating gene expression in the stroma and glands. Endocrinology. 2010 Sep;151(9):4515-26. doi: 10.1210/en.2009-1398. Epub 2010 Jul 21.
• [73] Dickkopf-1, an inhibitor of Wnt signaling, is regulated by progesterone in human endometrial stromal cells. J Clin Endocrinol Metab. 2006 Apr;91(4):1453-61. doi: 10.1210/jc.2005-0769. Epub 2006 Jan 31.
• [74] Progesterone rise on HCG day in GnRH antagonist/rFSH stimulated cycles affects endometrial gene expression. Reprod Biomed Online. 2011 Mar;22(3):263-71. doi: 10.1016/j.rbmo.2010.11.002. Epub 2010 Nov 13.
• [75] High levels of caveolar cholesterol inhibit progesterone-induced genomic actions in human and guinea pig gallbladder muscle. Am J Physiol Gastrointest Liver Physiol. 2009 Apr;296(4):G948-54. doi: 10.1152/ajpgi.90699.2008. Epub 2009 Feb 12.
• [76] Progestin regulates chemokine (C-X-C motif) ligand 14 transcript level in human endometrium. Mol Hum Reprod. 2010 Mar;16(3):170-7. doi: 10.1093/molehr/gap100. Epub 2009 Nov 10.
• [77] Progesterone pre-treatment potentiates EGF pathway signaling in the breast cancer cell line ZR-75. Breast Cancer Res Treat. 2005 Nov;94(2):171-83. doi: 10.1007/s10549-005-7726-6.
• [78] Thrombotic predisposition associated with oral contraceptives. Obstet Gynecol. 1973 Mar;41(3):427-35.
• [79] The impact of luteal phase support on gene expression of extracellular matrix protein and adhesion molecules in the human endometrium during the window of implantation following controlled ovarian stimulation with a GnRH antagonist protocol. Fertil Steril. 2010 Nov;94(6):2264-71. doi: 10.1016/j.fertnstert.2010.01.068. Epub 2010 Mar 12.
• [80] Progesterone and 17beta-estradiol enhance regulatory responses to human papillomavirus type 16 virus-like particles in peripheral blood mononuclear cells from healthy women. Clin Vaccine Immunol. 2010 Apr;17(4):609-17. doi: 10.1128/CVI.00441-09. Epub 2010 Feb 3.
• [81] Progesterone-dependent release of transforming growth factor-beta1 from epithelial cells enhances the endometrial decidualization by turning on the Smad signalling in stromal cells. Mol Hum Reprod. 2005 Nov;11(11):801-8. doi: 10.1093/molehr/gah240. Epub 2006 Jan 10.
• [82] Progesterone but not estradiol 17beta potentiates local GH secretions by hormone-dependent breast cancer explants. An in vitro study. Exp Clin Endocrinol Diabetes. 2005 Feb;113(2):127-32. doi: 10.1055/s-2004-830556.
• [83] Progesterone and calcitriol attenuate inflammatory cytokines CXCL1 and CXCL2 in ovarian and endometrial cancer cells. J Cell Biochem. 2012 Oct;113(10):3143-52. doi: 10.1002/jcb.24191.
• [84] Elucidating progesterone effects in breast cancer: cross talk with PDGF signaling pathway in smooth muscle cell. J Cell Biochem. 2007 Jan 1;100(1):174-83. doi: 10.1002/jcb.21045.
• [85] Characterization of Oryzias latipes glucocorticoid receptors and their unique response to progestins. J Appl Toxicol. 2015 Mar;35(3):302-9. doi: 10.1002/jat.3020. Epub 2014 Jul 23.
• [86] Human sex hormone-binding globulin binding affinities of 125 structurally diverse chemicals and comparison with their binding to androgen receptor, estrogen receptor, and -fetoprotein. Toxicol Sci. 2015 Feb;143(2):333-48. doi: 10.1093/toxsci/kfu231. Epub 2014 Oct 27.
• [87] Progesterone inhibits human endothelial cell proliferation through a p53-dependent pathway. Cell Mol Life Sci. 2008 Nov;65(23):3839-50. doi: 10.1007/s00018-008-8441-3.
• [88] Glucocorticoid regulation of human pulmonary surfactant protein-B (SP-B) mRNA stability is independent of activated glucocorticoid receptor. Am J Physiol Lung Cell Mol Physiol. 2011 Jun;300(6):L940-50. doi: 10.1152/ajplung.00420.2010. Epub 2011 Mar 11.
• [89] Transactivation via the human glucocorticoid and mineralocorticoid receptor by therapeutically used steroids in CV-1 cells: a comparison of their glucocorticoid and mineralocorticoid properties. Eur J Endocrinol. 2004 Sep;151(3):397-406. doi: 10.1530/eje.0.1510397.
• [90] Reduced expression of progesterone receptor-B in the endometrium of women with endometriosis and in cocultures of endometrial cells exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. Fertil Steril. 2005 Jul;84(1):67-74. doi: 10.1016/j.fertnstert.2005.01.113.
• [91] A Gene Expression Biomarker Identifies Chemical Modulators of Estrogen Receptor in an MCF-7 Microarray Compendium. Chem Res Toxicol. 2021 Feb 15;34(2):313-329. doi: 10.1021/acs.chemrestox.0c00243. Epub 2021 Jan 6.
• [92] Differential regulation of glucose transporter expression by estrogen and progesterone in Ishikawa endometrial cancer cells. J Endocrinol. 2004 Sep;182(3):467-78. doi: 10.1677/joe.0.1820467.
• [93] [Regulation of orphan receptor ERR alpha by estrogen and progesterone in endometrial carcinoma cell line]. Beijing Da Xue Xue Bao Yi Xue Ban. 2005 Jun 18;37(3):281-3.
• [94] Expression of cystic fibrosis transmembrane conductance regulator in human endometrium. Hum Reprod. 2004 Dec;19(12):2933-41. doi: 10.1093/humrep/deh507. Epub 2004 Oct 7.
• [95] Progesterone increases tissue factor gene expression, procoagulant activity, and invasion in the breast cancer cell line ZR-75-1. J Clin Endocrinol Metab. 2005 Feb;90(2):1181-8. doi: 10.1210/jc.2004-0857. Epub 2004 Nov 23.
• [96] [Mifepristone inhibits the progesterone-induced expressions of HLA-G, -E, -F genes in trophoblasts during first trimester]. Zhonghua Yi Xue Za Zhi. 2012 Jan 3;92(1):15-7.
• [97] The expression pattern of MUC1 glycoforms and other biomarkers of endometrial receptivity in fertile and infertile women. Mol Reprod Dev. 2005 Oct;72(2):216-29. doi: 10.1002/mrd.20307.
• [98] Progesterone induction of chondroitin sulfate proteoglycan aggrecan expression in human endometrial epithelial cells. J Steroid Biochem Mol Biol. 2010 Oct;122(4):159-63. doi: 10.1016/j.jsbmb.2010.07.004. Epub 2010 Jul 29.
• [99] Progesterone enhances HLA-G gene expression in JEG-3 choriocarcinoma cells and human cytotrophoblasts in vitro. Hum Reprod. 2006 Jan;21(1):46-51. doi: 10.1093/humrep/dei305. Epub 2005 Oct 6.
• [100] Progesterone decreases bone morphogenetic protein (BMP) 7 expression and BMP7 inhibits decidualization and proliferation in endometrial stromal cells. Hum Reprod. 2010 Mar;25(3):751-6. doi: 10.1093/humrep/dep455. Epub 2010 Jan 18.
• [101] Identification of ATF-3, caveolin-1, DLC-1, and NM23-H2 as putative antitumorigenic, progesterone-regulated genes for ovarian cancer cells by gene profiling. Oncogene. 2005 Mar 3;24(10):1774-87. doi: 10.1038/sj.onc.1207991.
• [102] Differential effects of estrogen and progesterone on potassium channels expressed in Xenopus oocytes. Steroids. 2008 Mar;73(3):272-9. doi: 10.1016/j.steroids.2007.10.010. Epub 2007 Nov 4.
• [103] Progesterone induces the fibulin-1 expression in human endometrial stromal cells. Hum Reprod. 2005 Jun;20(6):1447-55. doi: 10.1093/humrep/deh841. Epub 2005 Mar 17.
• [104] Differential expression of calreticulin, a reticuloplasmin in primate endometrium. Hum Reprod. 2009 Sep;24(9):2205-16. doi: 10.1093/humrep/dep187. Epub 2009 May 21.
• [105] Progesterone modulation of alpha5 nAChR subunits influences anxiety-related behavior during estrus cycle. Genes Brain Behav. 2009 Jun;8(4):398-406. doi: 10.1111/j.1601-183X.2009.00476.x. Epub 2009 Feb 11.
• [106] Gonadal steroids regulate GABAA receptor subunit mRNA expression in NT2-N neurons. Brain Res Mol Brain Res. 2005 Aug 18;138(2):105-15. doi: 10.1016/j.molbrainres.2004.10.047.
• [107] Identification of a novel corticotropin-releasing hormone type 1beta-like receptor variant lacking Exon 13 in human pregnant myometrium regulated by estradiol-17beta and progesterone. Endocrinology. 2010 Oct;151(10):4959-68. doi: 10.1210/en.2010-0622. Epub 2010 Aug 11.
• [108] [Effects of estradiol and progesterone on the expression of insulin receptor substrate in human osteoblasts]. Zhonghua Yi Xue Za Zhi. 2005 Mar 23;85(11):743-6.
• [109] The DEK oncogene is a target of steroid hormone receptor signaling in breast cancer. PLoS One. 2012;7(10):e46985. doi: 10.1371/journal.pone.0046985. Epub 2012 Oct 10.
• [110] Progesterone and human placental lactogen inhibit leptin secretion on cultured trophoblast cells from human placentas at term. Gynecol Endocrinol. 2005 Jul;21(1):27-32. doi: 10.1080/09513590500099305.
• [111] The human myometrium differentially expresses mTOR signalling components before and during pregnancy: evidence for regulation by progesterone. J Steroid Biochem Mol Biol. 2014 Jan;139:166-72. doi: 10.1016/j.jsbmb.2013.02.017. Epub 2013 Mar 26.
• [112] Progesterone and 1,25-dihydroxyvitamin D? inhibit endometrial cancer cell growth by upregulating semaphorin 3B and semaphorin 3F. Mol Cancer Res. 2011 Nov;9(11):1479-92. doi: 10.1158/1541-7786.MCR-11-0213. Epub 2011 Sep 20.
• [113] Expression of endometrial glycogen synthase kinase-3beta protein throughout the menstrual cycle and its regulation by progesterone. Mol Hum Reprod. 2006 Sep;12(9):543-9. doi: 10.1093/molehr/gal065. Epub 2006 Aug 1.
• [114] Conditional regulation of the human CYP4X1 and CYP4Z1 genes. Arch Biochem Biophys. 2005 Apr 15;436(2):377-85. doi: 10.1016/j.abb.2005.02.022.
• [115] Regulation of human organic anion transporter 4 by progesterone and protein kinase C in human placental BeWo cells. Am J Physiol Endocrinol Metab. 2007 Jul;293(1):E57-61. doi: 10.1152/ajpendo.00696.2006. Epub 2007 Mar 6.
• [116] Bisphenol A prevents MCF-7 breast cell apoptosis via the inhibition of progesterone receptor transactivation. J Biochem Mol Toxicol. 2023 Jul;37(7):e23367. doi: 10.1002/jbt.23367. Epub 2023 Apr 3.
• [117] Regulation of estrogen receptor (ER) levels in MCF-7 cells by progesterone metabolites. J Steroid Biochem Mol Biol. 2007 Nov-Dec;107(3-5):172-9. doi: 10.1016/j.jsbmb.2007.05.030. Epub 2007 Jun 22.
• [118] Adiponectin Reverses the Proliferative Effects of Estradiol and IGF-1 in Human Epithelial Ovarian Cancer Cells by Downregulating the Expression of Their Receptors. Horm Cancer. 2018 Jun;9(3):166-174. doi: 10.1007/s12672-018-0331-z. Epub 2018 Mar 30.
• [119] A novel protein Depp, which is induced by progesterone in human endometrial stromal cells activates Elk-1 transcription factor. Mol Hum Reprod. 2005 Jul;11(7):471-6. doi: 10.1093/molehr/gah186.
• [120] Regulation of A Disintegrin And Metalloproteinase with ThromboSpondin repeats-1 expression in human endometrial stromal cells by gonadal steroids involves progestins, androgens, and estrogens. J Clin Endocrinol Metab. 2006 Dec;91(12):4825-35. doi: 10.1210/jc.2006-1567. Epub 2006 Oct 3.
• [121] Role of HERV-W syncytin-1 in placentation and maintenance of human pregnancy. Appl Immunohistochem Mol Morphol. 2009 Jul;17(4):319-28. doi: 10.1097/PAI.0b013e31819640f9.
• [122] Delayed puberty in spontaneously hypertensive rats involves a primary ovarian failure independent of the hypothalamic KiSS-1/GPR54/GnRH system. Endocrinology. 2009 Jun;150(6):2889-97. doi: 10.1210/en.2008-1381. Epub 2009 Feb 19.
• [123] Corticotropin-releasing hormone inhibits progesterone production in cultured human placental trophoblasts. J Mol Endocrinol. 2006 Dec;37(3):533-40.
• [124] Heterozygous mutation in the cholesterol side chain cleavage enzyme (p450scc) gene in a patient with 46,XY sex reversal and adrenal insufficiency. J Clin Endocrinol Metab. 2001 Aug;86(8):3820-5. doi: 10.1210/jcem.86.8.7748.
• [125] Analysis of androgen receptor and anti-Mllerian hormone pathways in human granulosa cells under luteinizing hormone treatment. Reprod Biol Endocrinol. 2013 Feb 21;11:11. doi: 10.1186/1477-7827-11-11.
• [126] The crystal structure of human Delta4-3-ketosteroid 5beta-reductase defines the functional role of the residues of the catalytic tetrad in the steroid double bond reduction mechanism. Biochemistry. 2008 Aug 12;47(32):8261-70. doi: 10.1021/bi800572s. Epub 2008 Jul 15.
• [127] Gonadotrophin stimulation of non-luteinized granulosa cells increases steroid production and the expression of enzymes involved in estrogen and progesterone synthesis. Hum Reprod. 2007 Feb;22(2):401-6. doi: 10.1093/humrep/del408. Epub 2006 Nov 10.
• [128] Steroid signalling in the ovarian surface epithelium. Trends Endocrinol Metab. 2005 Sep;16(7):327-33.
• [129] Single nucleotide polymorphisms in the human corticosteroid-binding globulin promoter alter transcriptional activity. Sci China Life Sci. 2012 Aug;55(8):699-708. doi: 10.1007/s11427-012-4365-0. Epub 2012 Aug 30.
• [130] Human steroidogenic factor-1 (hSF-1) regulates progesterone biosynthesis and growth of ovarian surface epithelial cancer cells. J Steroid Biochem Mol Biol. 2010 Mar;119(1-2):14-25. doi: 10.1016/j.jsbmb.2009.11.006. Epub 2010 Jan 4.
• [131] Human types 1 and 3 3 alpha-hydroxysteroid dehydrogenases: differential lability and tissue distribution. J Clin Endocrinol Metab. 2001 Feb;86(2):841-6. doi: 10.1210/jcem.86.2.7216.
• [132] [Stimulation of HCG, estrogen and progesterone production in isolated trophoblast cells by glycodelin A or its N-glycans]. Z Geburtshilfe Neonatol. 2005 Apr;209(2):59-64. doi: 10.1055/s-2005-864115.
• [133] Melatonin exerts direct inhibitory actions on ACTH responses in the human adrenal gland. Horm Metab Res. 2011 May;43(5):337-42. doi: 10.1055/s-0031-1271693. Epub 2011 Feb 17.
• [134] Effects of the insecticide amitraz, an alpha2-adrenergic receptor agonist, on human luteinized granulosa cells. Hum Reprod. 2005 Nov;20(11):3018-25. doi: 10.1093/humrep/dei194. Epub 2005 Aug 5.
• [135] AKR1C4 gene variant associated with low euthymic serum progesterone and a history of mood irritability in males with bipolar disorder. J Affect Disord. 2011 Sep;133(1-2):346-51. doi: 10.1016/j.jad.2011.04.009. Epub 2011 May 12.
• [136] Functional characterization of mutant CYP17 genes isolated from a 17 alpha-hydroxylase/17,20-lyase-deficient patient. Metabolism. 2004 Dec;53(12):1527-31. doi: 10.1016/j.metabol.2004.05.018.
• [137] Clinical pipeline report, company report or official report of Pantarhei Bioscience.