Details of the Drug Combinations

General Information of This Drug (ID: DMVM6QR)

Drug Name

Lacosamide DMVM6QR

Synonyms

Erlosamide; Harkoseride; Vimpat; Erlosamide [INN]; Lacosamide [USAN]; ADD 234037; SPM 927; ADD-234037; SPM-927; SPM-929; Erlosamide, Vimpat, Lacosamide; Lacosamide (USAN/INN); (2R)-2-(Acetylamino)-N-benzyl-3-methoxypropanamide; (2R)-2-(acetylamino)-N-benzyl-3-methoxypropanamide; (2R)-2-acetamido-N-benzyl-3-methoxypropanamide

Indication

Disease Entry	ICD 11	Status	REF
Convulsion	8A68.Z	Approved	[1]
Epilepsy	8A60-8A68	Approved	[2]
Diabetic neuropathy	8C0Z	Phase 3	[1]
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Therapeutic Class

Analgesics

Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

105 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Acamprosate + Lacosamide	DCTNDHJ	Acamprosate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Acetohexamide + Lacosamide	DCQZIIO	Acetohexamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amiloride + Lacosamide	DCXAA1J	Amiloride	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Amodiaquine + Lacosamide	DC5A445	Amodiaquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Anamorelin + Lacosamide	DCFOVG0	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Armodafinil + Lacosamide	DC9B1PP	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Baclofen + Lacosamide	DCI27B7	Baclofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
BHV-0223 + Lacosamide	DCI5MN0	BHV-0223	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Brincidofovir + Lacosamide	DCL79VI	Brincidofovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cerivastatin + Lacosamide	DC20KXZ	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Chlormezanone + Lacosamide	DCPHJWK	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cisatracurium + Lacosamide	DCPSBO7	Cisatracurium	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Cytarabine + Lacosamide	DCA2W4O	Cytarabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Dantrolene + Lacosamide	DC2L73L	Dantrolene	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Diethylcarbamazine + Lacosamide	DCNS1RU	Diethylcarbamazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Docetaxel + Lacosamide	DCMXP9E	Docetaxel	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Emetine + Lacosamide	DCIXIGJ	Emetine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Endoxifen + Lacosamide	DC1DCPH	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Epinephrine + Lacosamide	DCP2OJ4	Epinephrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Etomidate + Lacosamide	DCLXWAB	Etomidate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Ezetimibe + Lacosamide	DC0AE8Y	Ezetimibe	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Fomepizole + Lacosamide	DCQE8LK	Fomepizole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Furazolidone + Lacosamide	DCU5BET	Furazolidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Galantamine + Lacosamide	DCN8XP2	Galantamine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Gefitinib + Lacosamide	DC1NNE9	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Hyodeoxycholic acid + Lacosamide	DC5Y247	Hyodeoxycholic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Imatinib + Lacosamide	DCL90KB	Imatinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
L-165041 + Lacosamide	DC0Q3CA	L-165041	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Picoplatin	DC110EM	Picoplatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Gefitinib	DCK8QKG	Gefitinib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Aliskiren	DCONPDB	Aliskiren	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Lumefantrine	DCC0M2L	Lumefantrine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Furazolidone	DCQ79XV	Furazolidone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + LIAROZOLE	DC7DDEM	LIAROZOLE	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Trioxsalen	DCQPGI1	Trioxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Mephenytoin	DC0E5SI	Mephenytoin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Anamorelin	DC81SCR	Anamorelin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Triapine	DCVQM6A	Triapine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Everolimus	DC1RC1K	Everolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + 10-hydroxycamptothecin	DC25PFQ	10-hydroxycamptothecin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Chlorzoxazone	DC8DYAM	Chlorzoxazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Phenprocoumon	DCLKVS8	Phenprocoumon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Sulfinpyrazone	DC99BZH	Sulfinpyrazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Armodafinil	DCCCFPJ	Armodafinil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Zaleplon	DC7HIRM	Zaleplon	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Diphenidol	DCX2HQ9	Diphenidol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Bosentan	DCSK3Z6	Bosentan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + PF-02545920	DCXDCOV	PF-02545920	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Isoproterenol	DCDY2PP	Isoproterenol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Trifluoperazine	DCV56LR	Trifluoperazine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Diazoxide	DCX6K6P	Diazoxide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Fenoprofen	DCJ535S	Fenoprofen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Probenecid	DCYSGQU	Probenecid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Abacavir	DCCJLC5	Abacavir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Atenolol	DC2YF8W	Atenolol	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Artemisinin	DCDEV17	Artemisinin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Trimethobenzamide	DC0R3U1	Trimethobenzamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Maprotiline	DCKHU2B	Maprotiline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Oxyphenbutazone	DCENPPB	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Leflunomide	DC1Q13S	Leflunomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Quinine	DCWRD2D	Quinine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Chlormezanone	DC8Y1UZ	Chlormezanone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Endoxifen	DCFOTQ5	Endoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Mycophenolic acid	DCPA9DG	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Oxandrolone	DCR0ZAM	Oxandrolone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Mefloquine	DCW3BOR	Mefloquine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Doxorubicin	DCZHVR8	Doxorubicin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Zileuton	DCHL0WN	Zileuton	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Auranofin	DCRN4KB	Auranofin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Cerivastatin	DCEVILY	Cerivastatin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Aciclovir	DCICNUA	Aciclovir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Raltegravir	DCZD34V	Raltegravir	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Acetohydroxamic Acid	DCKUI6S	Acetohydroxamic Acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Azatadine	DCD1V2G	Azatadine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + Nitrosoglutathione	DCDMPHL	Nitrosoglutathione	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Lacosamide + L-165041	DCDQMMT	L-165041	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Loperamide + Lacosamide	DCBAN9W	Loperamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Maraviroc + Lacosamide	DCEKLDG	Maraviroc	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methotrexate + Lacosamide	DCXEWHA	Methotrexate	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methoxsalen + Lacosamide	DC2IIDC	Methoxsalen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Methylene blue + Lacosamide	DCOD7ZM	Methylene blue	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Metyrosine + Lacosamide	DC7U95P	Metyrosine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Miconazole + Lacosamide	DC4IYMP	Miconazole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Mycophenolic acid + Lacosamide	DC73JB3	Mycophenolic acid	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Novobiocin + Lacosamide	DC5UQLW	Novobiocin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Olmesartan medoxomil + Lacosamide	DCI6MNL	Olmesartan medoxomil	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Oxyphenbutazone + Lacosamide	DC06RT8	Oxyphenbutazone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Paromomycin + Lacosamide	DC8L6IQ	Paromomycin	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pazopanib + Lacosamide	DCPA3RT	Pazopanib	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pentamidine + Lacosamide	DC6A4CR	Pentamidine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PFK-158 + Lacosamide	DC5EDNT	PFK-158	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pizotyline + Lacosamide	DCX0WN4	Pizotyline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
PMID28460551-Compound-2 + Lacosamide	DCJFI8V	PMID28460551-Compound-2	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pomalidomide + Lacosamide	DCSVV1D	Pomalidomide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pramipexole + Lacosamide	DC1MS8O	Pramipexole	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Pyrazinamide + Lacosamide	DCG31D1	Pyrazinamide	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Sulfapyridine + Lacosamide	DCKTJH1	Sulfapyridine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tacrolimus + Lacosamide	DCEIJM5	Tacrolimus	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tamoxifen + Lacosamide	DC9V95H	Tamoxifen	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Testolactone + Lacosamide	DC28I2O	Testolactone	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Theophylline + Lacosamide	DCTMMK7	Theophylline	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Tiagabine + Lacosamide	DCFYQ75	Tiagabine	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Topotecan + Lacosamide	DC4R1QU	Topotecan	Chronic myelogenous leukemia (Cell Line: KBM-7)	[4]
Trihexyphenidyl + Lacosamide	DC8FL4M	Trihexyphenidyl	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
Vorinostat + Lacosamide	DCO8UTY	Vorinostat	Chronic myelogenous leukemia (Cell Line: KBM-7)	[3]
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⏷ Show the Full List of 105 DrugCom(s)

3 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Levetiracetam + Lacosamide	DC8IOQB	Levetiracetam	Epilepsy	[5]
Diclofenac + Lacosamide	DCDMX1S	Diclofenac	Sciatica Acute	[6]
Ibuprofen + Lacosamide	DCBRHFG	Ibuprofen	Effect of Drug	[7]
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References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7472).
2	Antibodies and venom peptides: new modalities for ion channels. Nat Rev Drug Discov. 2019 May;18(5):339-357.
3	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
4	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
5	ClinicalTrials.gov (NCT01345058) Add on Lacosamide Versus High Dose Monotherapy
6	ClinicalTrials.gov (NCT05626140) COMPARISON OF EFFICACY OF DIFFERENT DRUG COMBINATIONS IN ACUTE SCIATICA
7	ClinicalTrials.gov (NCT05632133) The Lacosamide's Effect on Calcitonin Gene-related Peptide in Migraine Patients