Details of the Drug Combinations

General Information of This Drug (ID: DMVU687)

• Drug Name: Esketamine (DMVU687)
• Synonyms: (S)-Ketamine; l-Ketamine; (S)-(-)-Ketamine; 33643-46-8; S-Ketamine; UNII-50LFG02TXD; 50LFG02TXD; (S)-2-(o-chlorophenyl)-2-(methylamino)cyclohexanone; CHEBI:60799; esketamine HCl; (2S)-2-(2-chlorophenyl)-2-(methylamino)cyclohexanone; cyclohexanone, 2-(2-chlorophenyl)-2-(methylamino)-, (2S)-; 6740-88-1 (Parent); Esketamine [USAN:INN:BAN]; S-Ketamin; S-(-)-Ketamine; Esketamine (USAN/INN); AC1L4AD8; DSSTox_CID_27787; DSSTox_RID_82562; DSSTox_GSID_47810; SCHEMBL5512024; GTPL9152; CHEMBL395091; DTXSID6047810; YQEZ

Indication

Depression; ICD 11: 6A70-6A7Z; Status: Phase 3 [1]

List of Combinatorial Drugs (CBD) Containing This Drug

9 Clinical Trial Drug Combination(s) Consisting of This drug

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
Ketamine + Esketamine	DCN4IIW	Ketamine	Treatment Resistant Depression	[2]
Mometasone + Esketamine	DC8OJ0X	Mometasone	Allergic Rhinitis	[3]
Oxymetazoline + Esketamine	DC7AM0S	Oxymetazoline	Allergic Rhinitis	[3]
Propofol + Esketamine	DC80MV1	Propofol	Drug Effect	[4]
Propofol + Esketamine	DCWGBII	Propofol	Pain	[5]
Propofol + Esketamine	DCZB2CW	Propofol	Patients With Septic Shock Admitted to the ICU on Invasive Mechanical Ventilation	[6]
Remimazolam + Esketamine	DCV6J8R	Remimazolam	Drug Effect	[4]
Remimazolam + Esketamine	DCAB46G	Remimazolam	Anesthesia	[7]
Ketamine + Esketamine	DCMABAL	Ketamine	Major Depressive Disorder	[8]

References

• [1] Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
• [2] ClinicalTrials.gov (NCT04480918) University of Iowa Interventional Psychiatry Service Patient Registry
• [3] ClinicalTrials.gov (NCT02154334) Study to Assess the Effects of Allergic Rhinitis and Co-administration of Mometasone or Oxymetazoline on the Pharmacokinetics, Safety, and Tolerability of Intranasal Esketamine
• [4] ClinicalTrials.gov (NCT05686863) Remiazolam Combined With Esketamine in Painless Bidirectional Endoscopy in Children
• [5] ClinicalTrials.gov (NCT04691076) Effect of Low-dose Esketamine Combined With Target-controlled Infusion of Propofol for Painless Gastrointestinal Endoscopy
• [6] ClinicalTrials.gov (NCT05551910) Comparison of Analgesic and Sedative Effects of Esmketamine and Remifentanil Combined With Propofol Respectively in Septic Shock Patients With Invasive Mechanical Ventilation
• [7] ClinicalTrials.gov (NCT05635955) Remimazolam Versus Propofol for Painless Abortion
• [8] ClinicalTrials.gov (NCT05450432) Long-Term Maintenance With Ketamine and Esketamine for Reduction of Suicide in High-Risk Patients With Depression