General Information of This Drug (ID: DMVY4GN)

Drug Name
Testolactone   DMVY4GN
Synonyms
Fludestrin; Teolit; Teslac; Teslak; Testolacton; Testolactona; Testolactonum; Testolattone; Bristol Myers SquibbBrand of Testolactone; Testolattone [DCIT]; SQ 9538; Bristol-Myers Squibb Brand of Testolactone; DELTA1-Dehydrotestolactone; DELTA1-Dehydrotestololactone; DELTA1-Testololactone; SQ-9538; TESLAC (TN);Teslac (TN); Testolactona [INN-Spanish]; Testolactone [USAN:INN]; Testolactonum [INN-Latin]; Delta(1)-Dehydrotestolactone; Delta(1)-Testolactone; Delta(1)-Testololactone; Delta(1)-testololactone; Delta-1-testololactone; Testolactone (USP/INN); D-Homo-17A-oxaandrosta-1,4-diene-3,17-dione; D-homo-17a-oxaandrosta-1,4-diene-3,17-dione; (4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-3,4,4a,5,6,10a,10b,11,12,12a-decahydro-2H-naphtho[2,1-f]chromene-2,8(4bH)-dione; (4aS,4bR,10aR,10bS,12aS)-10a,12a-dimethyl-4,4a,4b,5,6,10b,11,12-octahydro-3H-naphtho[2,1-f]chromene-2,8-dione; 1 Dehydrotestolactone; 1,2,3,4,4a,4b,7,9,10,10a-Decahydro-2-hydroxy-2,4b-dimethyl-7-oxo-1-phenanthrenepropionic acid delta-lactone; 1,2-Dehydrotestololactone; 1,2-Didehydrotestololactone; 1,2-didehydrotestololactone; 1-Dehydrotestolactone; 1-Dehydrotestololactone; 1-dehydrotestololactone; 13,17-Secoandrosta-1,4-dien-17-oic acid, 13-hydroxy-3-oxo-, .delta.-lactone; 13,17-Secoandrosta-1,4-dien-17-oic acid, 13-hydroxy-3-oxo-, delta-lactone; 13,17-Secoandrosta-1,4-dien-17-oic acid, 13-hydroxy-3-oxo-, delta-lactone (8CI); 13,17-Secoandrosta-1,4-dien-17-oic acid, 13-hydroxy-3-oxo-, lactone; 13,17-Secoandrosta-1,4-dien-17-oic acid, 13.alpha.-hydroxy-3-oxo-, .delta.-lactone; 13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid .delta.-lactone; 13-Hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid delta-lactone; 13-hydroxy-3-oxo-13,17-secoandrosta-1,4-dien-17-oic acid delta-lactone; 17a-Oxa-D-homoandrosta-1,4-diene-3,17-dione; 17alpha-Oxo-D-homo-1,4-androstadiene-3,17-dione; 2H-Phenanthro[2,1-b]pyran-2,8(4bH)-dione, 3,4,4a,5,6,10a,10b,11,12,12a-decahydro-10a,12a-dimethyl-, lactone; 3-oxo-13,17-secoandrosta-1,4-dieno-17,13alpha-lactone
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Therapeutic Class
Anticancer Agents
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

63 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
Aciclovir + Testolactone DCE7ZCH Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acitretin + Testolactone DC6MZ8Z Acitretin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Arfolitixorin + Testolactone DCC48AP Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Armodafinil + Testolactone DCWS59A Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bepridil + Testolactone DCRFTRU Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BIO-300 + Testolactone DCVJ7LB BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bortezomib + Testolactone DC8CNZR Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Brincidofovir + Testolactone DCAX0PL Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Testolactone DC6KBF5 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Citalopram + Testolactone DCJG099 Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Diphenidol + Testolactone DCUUTPB Diphenidol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Endoxifen + Testolactone DC70H1G Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Epinephrine + Testolactone DCJ414H Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Estramustine + Testolactone DCIPOBI Estramustine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ETHISTERONE + Testolactone DCUHC6H ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fenoprofen + Testolactone DCITJWQ Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + Testolactone DC5MBQ8 Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Testolactone DC9FRM2 GSK2194069 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Hyodeoxycholic acid + Testolactone DCZSZ9J Hyodeoxycholic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Testolactone DCDD0QH Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
IT-141 + Testolactone DCOIBPS IT-141 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Testolactone DCAXIZ7 K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lefaxin + Testolactone DCBRSLM Lefaxin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Leflunomide + Testolactone DCMSD3V Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Testolactone DC1DDJB Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylergonovine + Testolactone DCDU6IQ Methylergonovine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Niclosamide + Testolactone DC5P7A9 Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PF-02545920 + Testolactone DCT2GVA PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pizotyline + Testolactone DCXK2NA Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + Testolactone DCABBPS PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ribavirin-TP + Testolactone DC9YQ3L Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tamoxifen + Testolactone DC04DYR Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terazosin + Testolactone DCWJF6L Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Aliskiren DCM9NK9 Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Dantrolene DC1DIMB Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Diethylcarbamazine DCJZM31 Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Triapine DCOLF3J Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Everolimus DC5UNUE Everolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Metyrosine DC4ECWN Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Guanfacine DCCMF15 Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Chlorzoxazone DC4B2B6 Chlorzoxazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Docetaxel DCXO70E Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Sulfinpyrazone DC2XW1G Sulfinpyrazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Armodafinil DCE8QMH Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Ciprofibrate DCIH7CX Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Sitagliptin DCT3ZFE Sitagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Pentamidine DC4RFDK Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Tiagabine DCXQSTN Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Atenolol DCXG487 Atenolol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Pramipexole DCGISJ7 Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Clascoterone DC3SGDK Clascoterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Trimethobenzamide DCCB62U Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Maprotiline DC2N1DE Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Oxyphenbutazone DCQLDVI Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Quinine DCT12F7 Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Mycophenolic acid DCFU9LA Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Lacosamide DC28I2O Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Auranofin DCQEEN9 Auranofin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + FORMESTANE DCBJEW1 FORMESTANE Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Vorinostat DCT8VYY Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Cytarabine DC23NB0 Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Theophylline + Testolactone DCGY17F Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triflupromazine + Testolactone DCL52DY Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 63 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7303).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.