Details of the Drug Combinations

General Information of This Drug (ID: DMWE2N4)

Drug Name
Auranofin   DMWE2N4
Synonyms
Ridaura; Ridauran; Ridaura (TN); SK&F 39162; SK&F-39162; Gold, (1-thio-.beta.-D-glucopyranosato)(triethylphosphine)-, 2,3,4,6-tetraacetate; (1-Thio-.beta.-D-glucopyranosato)(triethylphosphine)gold 2,3,4,6-tetraacetate
Indication
Disease Entry ICD 11 Status REF
Inflammatory arthritis FA2Z Approved [1]
Therapeutic Class
Antirheumatic Agents
Drug Type
Small molecular drug
Structure
3D MOL is unavailable 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

153 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole + Auranofin DCOA7RJ 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Abacavir + Auranofin DCQRZ23 Abacavir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ABT-263 + Auranofin DCA6KJW ABT-263 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Acamprosate + Auranofin DCZF35R Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Acetohydroxamic Acid + Auranofin DCWN3KB Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aciclovir + Auranofin DC77Z7N Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aliskiren + Auranofin DCDLX8Q Aliskiren Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Amantadine + Auranofin DCS7RA4 Amantadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Anamorelin + Auranofin DC8VWWT Anamorelin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Aprepitant + Auranofin DC5VV3J Aprepitant Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Asenapine + Auranofin DC4ZK74 Asenapine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Lefaxin DC08NAV Lefaxin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Sertraline DCQTPGP Sertraline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Triiodothyronine DCBB2FG Triiodothyronine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Gefitinib DCCTIUR Gefitinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Auranofin + Gefitinib DCFOYLP Gefitinib Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
Auranofin + Ruxolitinib DCMO455 Ruxolitinib Hodgkin lymphoma (Cell Line: L-1236) [2]
Auranofin + Kanamycin DCU5PFS Kanamycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Citalopram DCLC3EE Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Crotamiton DC7PQPU Crotamiton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Panobinostat DCWJJQ9 Panobinostat Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Auranofin + Miglustat DCM6WXG Miglustat Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Testosterone DC7DRRM Testosterone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Cinacalcet DCVQXCF Cinacalcet Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Doxapram DC7ERZ4 Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Marizomib DCOCGYW Marizomib Diffuse intrinsic pontine glioma (Cell Line: DIPG25) [2]
Auranofin + Phensuximide DC66FXU Phensuximide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Fluspirilene DCC1XSR Fluspirilene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Armodafinil DCC6TUG Armodafinil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Mifepristone DCN4FPD Mifepristone Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Auranofin + BIO-300 DCXL7HT BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Trazodone DCE7MMK Trazodone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Etonogestrel DCEVJQ9 Etonogestrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Fenoprofen DCORF7I Fenoprofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Tamoxifen DCRZ4KA Tamoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Idarubicin DCPYMXS Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Methocarbamol DC4HALH Methocarbamol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Probenecid DCJZGSV Probenecid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Bortezomib DCH8RJF Bortezomib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Tropisetron DC1C9WG Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Artemisinin DCI3QVT Artemisinin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Cefmenoxime DCT9Y8D Cefmenoxime Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Oxyphenbutazone DCG2BJE Oxyphenbutazone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Acarbose DCVK8VN Acarbose Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Chloroquine DCUKWGC Chloroquine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Naltrexone DCCX0UP Naltrexone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Quinine DC4C6TZ Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Pomalidomide DCZYYZS Pomalidomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Chlormezanone DCZ3GC6 Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Mycophenolic acid DCOE1P1 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Hydralazine DCP6VJX Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Pizotyline DCAG96U Pizotyline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Zileuton DC8WXO6 Zileuton Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Sumatriptan DCHP6LW Sumatriptan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Olmesartan medoxomil DCLWVFC Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Metaxalone DCVV5E6 Metaxalone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Busulfan DCGQN7D Busulfan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Enoxacin DC8XOTZ Enoxacin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Raltegravir DCTEL6A Raltegravir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + AS-1949490 DCPZ0XG AS-1949490 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Auranofin + Tetracycline DC3JYPC Tetracycline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Azatadine + Auranofin DCOOKSK Azatadine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Baclofen + Auranofin DCWVTLB Baclofen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bardoxolone methyl + Auranofin DCH5DPN Bardoxolone methyl Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Bardoxolone methyl + Auranofin DCXQRXB Bardoxolone methyl Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
Benserazide + Auranofin DCOZY58 Benserazide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bepridil + Auranofin DCINEYX Bepridil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
BHV-0223 + Auranofin DC75DFZ BHV-0223 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Bosentan + Auranofin DC4W1O8 Bosentan Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Buspirone + Auranofin DCURMO6 Buspirone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Carfilzomib + Auranofin DCV60XW Carfilzomib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Carglumic acid + Auranofin DCN4WC4 Carglumic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cerivastatin + Auranofin DCC5VF3 Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cevimeline + Auranofin DCBI4CW Cevimeline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chlorambucil + Auranofin DCCWSNN Chlorambucil Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Chloroquine + Auranofin DC0SY6B Chloroquine Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Chloroquine + Auranofin DC7B49O Chloroquine Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
Cilastatin + Auranofin DCO2O66 Cilastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cisatracurium + Auranofin DC671AO Cisatracurium Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Clopidogrel + Auranofin DCQQCD5 Clopidogrel Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Cytarabine + Auranofin DCHJQ1E Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Daporinad + Auranofin DC1SDH3 Daporinad Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Dihydroergotamine + Auranofin DCB6O31 Dihydroergotamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Endoxifen + Auranofin DCRLHPZ Endoxifen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Entacapone + Auranofin DCN0A6C Entacapone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
ETHISTERONE + Auranofin DCJL2YV ETHISTERONE Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ezetimibe + Auranofin DC2167M Ezetimibe Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Flavonoid derivative 1 + Auranofin DC4PY5Q Flavonoid derivative 1 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fomepizole + Auranofin DCHPH8Z Fomepizole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
FORMESTANE + Auranofin DCRLRZJ FORMESTANE Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Fosfomycin + Auranofin DCY18O7 Fosfomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Furazolidone + Auranofin DCAECZ5 Furazolidone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Galantamine + Auranofin DCYNZCX Galantamine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GDC-0980/RG7422 + Auranofin DC2FVKV GDC-0980/RG7422 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
GINKGOLIDE A + Auranofin DCYI6N4 GINKGOLIDE A Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GSK2194069 + Auranofin DCWUPTJ GSK2194069 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
GYKI-52466 + Auranofin DCT1WFS GYKI-52466 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ibutilide + Auranofin DCBZXZO Ibutilide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imatinib + Auranofin DCM257B Imatinib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Imipramine + Auranofin DCVA9HM Imipramine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Isoproterenol + Auranofin DCBKPNT Isoproterenol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
K-134 + Auranofin DCVSGSP K-134 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
L-165041 + Auranofin DCAHP24 L-165041 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lacosamide + Auranofin DCRN4KB Lacosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Leflunomide + Auranofin DCGQKKA Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Linagliptin + Auranofin DCRG845 Linagliptin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Lubiprostone + Auranofin DCXUQFX Lubiprostone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
LY03004 + Auranofin DC1W5J2 LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maprotiline + Auranofin DC190SR Maprotiline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Maraviroc + Auranofin DCBD8VA Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Mebutamate + Auranofin DCF9UOP Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Memantine + Auranofin DCTBN7D Memantine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Methylene blue + Auranofin DC72V6L Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Metyrosine + Auranofin DC3V8HV Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Moricizine + Auranofin DCST63J Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Nitisinone + Auranofin DCIO8IO Nitisinone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
NVP-AUY922 + Auranofin DC7OUGB NVP-AUY922 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Oseltamivir + Auranofin DC1IFBW Oseltamivir Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Palbociclib + Auranofin DC2KFVR Palbociclib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
Palbociclib + Auranofin DCKAKVD Palbociclib Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
Paromomycin + Auranofin DCKAR7C Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pazopanib + Auranofin DCZOPZN Pazopanib Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PD-0325901 + Auranofin DCRXA9P PD-0325901 Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
PD-0325901 + Auranofin DCK92WD PD-0325901 Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
Pentamidine + Auranofin DCXR1SF Pentamidine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PF-02545920 + Auranofin DCR28OS PF-02545920 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PFK-158 + Auranofin DC4AIDO PFK-158 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PHA-739358 + Auranofin DCSE9P1 PHA-739358 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Phenprocoumon + Auranofin DC4SDAF Phenprocoumon Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28460551-Compound-2 + Auranofin DC19W1G PMID28460551-Compound-2 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
PMID28870136-Compound-43 + Auranofin DCIFVWX PMID28870136-Compound-43 Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Pramipexole + Auranofin DCYHAE7 Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Procarbazine + Auranofin DCGZDXZ Procarbazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Repaglinide + Auranofin DC3BUS8 Repaglinide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Ribavirin-TP + Auranofin DC0GJM9 Ribavirin-TP Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Silver sulfadiazine + Auranofin DCUS5GD Silver sulfadiazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Spironolactone + Auranofin DC4MRVS Spironolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tacrolimus + Auranofin DCKL783 Tacrolimus Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terameprocol + Auranofin DCPCSO3 Terameprocol Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Terazosin + Auranofin DCA4ZXJ Terazosin Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Testolactone + Auranofin DCQEEN9 Testolactone Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
THAPSIGARGIN + Auranofin DCC1CT0 THAPSIGARGIN Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [2]
THAPSIGARGIN + Auranofin DCU3QFD THAPSIGARGIN Primitive neuroectodermal tumor (Cell Line: TC-32) [2]
Theophylline + Auranofin DC4SJV8 Theophylline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Tolazoline + Auranofin DC9ZU3F Tolazoline Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trametinib + Auranofin DCHMZEG Trametinib Diffuse intrinsic pontine glioma (Cell Line: SU-DIPG-XIII) [3]
Triamterene + Auranofin DCDR3D1 Triamterene Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trifluoperazine + Auranofin DCO2I3K Trifluoperazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Triflupromazine + Auranofin DC3ZX8D Triflupromazine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trimethobenzamide + Auranofin DCADOJG Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Trioxsalen + Auranofin DCRB17R Trioxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Valproic Acid + Auranofin DCGD3CK Valproic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
Vinblastine + Auranofin DC6082E Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [2]
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⏷ Show the Full List of 153 DrugCom(s)
2 Clinical Trial Drug Combination(s) Consisting of This drug
DrugCom Name DrugCom ID Component Drug Indication REF
Sirolimus + Auranofin DCPB4V0 Sirolimus Extensive Stage Small Cell Lung Carcinoma [4]
Sirolimus + Auranofin DCYDVDR Sirolimus Recurrent Non-small Cell Lung Cancer [5]
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References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6306).
2 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3 Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.
4 ClinicalTrials.gov (NCT01737502) Sirolimus and Auranofin in Treating Patients With Advanced or Recurrent Non-Small Cell Lung Cancer or Small Cell Lung Cancer
5 ClinicalTrials.gov (NCT02126527) Auranofin and Sirolimus in Treating Patients With Advanced Solid Tumors or Recurrent Non-Small Cell Lung Cancer