Details of the Drug Combinations

General Information of This Drug (ID: DMWE60C)

Drug Name
Rufinamide   DMWE60C
Synonyms
106308-44-5; Inovelon; Banzel; 1-(2,6-Difluorobenzyl)-1H-1,2,3-triazole-4-carboxamide; CGP-33101; Cgp 33101; Xilep; 1-[(2,6-difluorophenyl)methyl]-1H-1,2,3-Triazole-4-carboxamide; RUF-331; UNII-WFW942PR79; RUF 331; 1-[(2,6-difluorophenyl)methyl]triazole-4-carboxamide; WFW942PR79; C10H8F2N4O; E 2080; POGQSBRIGCQNEG-UHFFFAOYSA-N; 1H-1,2,3-Triazole-4-carboxamide, 1-[(2,6-difluorophenyl)methyl]-; NCGC00165883-02; E2080; DSSTox_CID_26506; DSSTox_RID_81675; DSSTox_GSID_46506; Banzel; Banzel, Rufinamide; E-2080; SYN-111; Rufinamide (USAN/INN); Inovelon/Banzel
Indication
Disease Entry ICD 11 Status REF
Epilepsy 8A60-8A68 Approved (orphan drug) [1]
Pediatric lennox-gastaut syndrome 8A62.1 Approved [2]
Seizure disorder 8A6Z Approved [1]
Drug Type
Small molecular drug
Structure
3D MOL 2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

56 Investigative Drug Combination(s) Consisting of This drug
Normalized Drug Combination Synergy Score
Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.
DrugCom Name DrugCom ID Component Drug Indication REF
1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole + Rufinamide DCIOIDF 1-((2-chlorophenyl)diphenylmethyl)-1H-pyrazole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acamprosate + Rufinamide DC153ZX Acamprosate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Acetazolamide + Rufinamide DCJH91J Acetazolamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Arfolitixorin + Rufinamide DCJIHTV Arfolitixorin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
BIO-300 + Rufinamide DC1WWR0 BIO-300 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Chlormezanone + Rufinamide DC8X9PZ Chlormezanone Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Citalopram + Rufinamide DC2WO5E Citalopram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Dantrolene + Rufinamide DCZKCY8 Dantrolene Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diazoxide + Rufinamide DCRBXGT Diazoxide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Diethylcarbamazine + Rufinamide DCL78ZI Diethylcarbamazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Docetaxel + Rufinamide DC53AWL Docetaxel Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Doxapram + Rufinamide DCSN2OL Doxapram Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Leflunomide + Rufinamide DCSFMUJ Leflunomide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Levamisole + Rufinamide DCAVQUZ Levamisole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
LY03004 + Rufinamide DCYWBCL LY03004 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Maraviroc + Rufinamide DCKW4X6 Maraviroc Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Pramipexole + Rufinamide DCHZFSS Pramipexole Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Quinine + Rufinamide DCRDO7F Quinine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Mebutamate DCWENQE Mebutamate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Paromomycin DC13PCS Paromomycin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Epinephrine DCQSDVA Epinephrine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Vinblastine DC38YRV Vinblastine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Ramelteon DC0T47X Ramelteon Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Triapine DCM7IX4 Triapine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Pepstatin DCTDJSO Pepstatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Rifampin DCTXNM1 Rifampin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Metyrosine DCFGVWR Metyrosine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Efavirenz DC94CZ8 Efavirenz Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Guanfacine DCT3PA3 Guanfacine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Emetine DC8UQHN Emetine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + JZL195 DCNOX11 JZL195 Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Ciprofibrate DCZVYUF Ciprofibrate Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Mecamylamine DC9PY2N Mecamylamine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Niclosamide DCR5NMQ Niclosamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Allopurinol DCM6VWY Allopurinol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Idarubicin DCPGGGV Idarubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Methylene blue DCOQV94 Methylene blue Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Tropisetron DCU8WM0 Tropisetron Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Moricizine DC2DT5Z Moricizine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Trimethobenzamide DCWTFWY Trimethobenzamide Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Brincidofovir DCS23PA Brincidofovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Mycophenolic acid DCLI2O0 Mycophenolic acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Hydralazine DCSQP4U Hydralazine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Doxorubicin DCJSYEU Doxorubicin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Iloprost DC0C9X8 Iloprost Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Olmesartan medoxomil DC0QVET Olmesartan medoxomil Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Vorinostat DC88BMD Vorinostat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Cerivastatin DCON0QV Cerivastatin Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Aciclovir DCL1ACS Aciclovir Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Acetohydroxamic Acid DCAQ10R Acetohydroxamic Acid Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Cytarabine DCK91ZV Cytarabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Rufinamide + Cilostazol DCBIMLW Cilostazol Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Sivelestat + Rufinamide DCBKS3D Sivelestat Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Tiagabine + Rufinamide DC3L7OK Tiagabine Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trihexyphenidyl + Rufinamide DCR83GC Trihexyphenidyl Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
Trioxsalen + Rufinamide DCW0K9T Trioxsalen Chronic myelogenous leukemia (Cell Line: KBM-7) [3]
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⏷ Show the Full List of 56 DrugCom(s)

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 7470).
2 Clinical pipeline report, company report or official report of Eisai.
3 Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.