Details of the Drug Combinations

General Information of This Drug (ID: DMZ0DMY)

Drug Name

LY2874455 DMZ0DMY

Synonyms

LY2874455; 1254473-64-7; LY-2874455; UNII-E9M363811V; CHEMBL3828009; E9M363811V; AK186860; LY 2874455; (R,E)-2-(4-(2-(5-(1-(3,5-Dichloropyridin-4-yl)-ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol; C21H19Cl2N5O2; (R,E)-2-(4-(2-(5-(1-(3,5-dichloropyridin-4-yl)ethoxy)-1H-indazol-3-yl)vinyl)-1H-pyrazol-1-yl)ethanol; GKJCVYLDJWTWQU-CXLRFSCWSA-N; SCHEMBL298446; SCHEMBL298445; QCR-90; GTPL8104; DTXSID20154776; MolPort-044-724-281; MolPort-023-219-117; EX-A1340; BCP04756; ZINC73069242; BDBM50189781; 2529AH; s7057; AKOS027251051

Indication

Disease Entry	ICD 11	Status	REF
Solid tumour/cancer	2A00-2F9Z	Phase 2	[1]
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Drug Type

Small molecular drug

Structure

3D MOL

2D MOL

List of Combinatorial Drugs (CBD) Containing This Drug

29 Investigative Drug Combination(s) Consisting of This drug

Normalized Drug Combination Synergy Score

Synergy scores were normalized using Min-Max Scaling to facilitate visual comparisons.

DrugCom Name	DrugCom ID	Component Drug	Indication	REF
(-)-englerin A + LY2874455	DCEZP78	(-)-englerin A	Ewing sarcoma (Cell Line: TC-71)	[2]
ABT-263 + LY2874455	DCIDPT7	ABT-263	Ewing sarcoma (Cell Line: TC-71)	[3]
Bardoxolone methyl + LY2874455	DC1AFS0	Bardoxolone methyl	Ewing sarcoma (Cell Line: TC-71)	[2]
Cantharidin + LY2874455	DC5L5CG	Cantharidin	Ewing sarcoma (Cell Line: TC-71)	[2]
Efaproxyn + LY2874455	DC37QNW	Efaproxyn	Ewing sarcoma (Cell Line: TC-71)	[2]
Everolimus + LY2874455	DCME4KT	Everolimus	Ewing sarcoma (Cell Line: TC-71)	[2]
Exherin + LY2874455	DCS2FMJ	Exherin	Ewing sarcoma (Cell Line: TC-71)	[2]
JQ1 + LY2874455	DCK29BS	JQ1	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + JQ1	DCYKKPZ	JQ1	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Carfilzomib	DCD2LNT	Carfilzomib	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Artemether	DCELQYC	Artemether	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Panobinostat	DCFXLFG	Panobinostat	Diffuse intrinsic pontine glioma (Cell Line: DIPG25)	[2]
LY2874455 + Panobinostat	DC135T0	Panobinostat	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Eltanexor oral	DC4QZ5J	Eltanexor oral	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + AZD8055	DCL8ZEO	AZD8055	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Formononetin	DC6NV5U	Formononetin	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + GDC-0084	DCOCQV8	GDC-0084	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Lenvatinib	DCNYEMT	Lenvatinib	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Exherin	DCJNDX2	Exherin	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + SCH 727965	DCEJHBP	SCH 727965	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + THAPSIGARGIN	DCHLTPJ	THAPSIGARGIN	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + PHA-739358	DCJJJ0I	PHA-739358	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Vincristine	DCQ2TLV	Vincristine	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Pelitinib	DCDCH9E	Pelitinib	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Lestaurtinib	DCNAMQ9	Lestaurtinib	Ewing sarcoma (Cell Line: TC-71)	[2]
LY2874455 + Romidepsin	DCCKF4O	Romidepsin	Ewing sarcoma (Cell Line: TC-71)	[2]
Nintedanib + LY2874455	DC8537I	Nintedanib	Ewing sarcoma (Cell Line: TC-71)	[2]
Panobinostat + LY2874455	DCENLG2	Panobinostat	Ewing sarcoma (Cell Line: TC-71)	[2]
Ym155 + LY2874455	DCC8XGE	Ym155	Ewing sarcoma (Cell Line: TC-71)	[2]
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⏷ Show the Full List of 29 DrugCom(s)

References

1	URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 8104).
2	Recurrent recessive mutation in deoxyguanosine kinase causes idiopathic noncirrhotic portal hypertension.Hepatology. 2016 Jun;63(6):1977-86. doi: 10.1002/hep.28499. Epub 2016 Mar 31.
3	Loss of function mutations in VARS encoding cytoplasmic valyl-tRNA synthetase cause microcephaly, seizures, and progressive cerebral atrophy.Hum Genet. 2018 Apr;137(4):293-303. doi: 10.1007/s00439-018-1882-3. Epub 2018 Apr 24.