Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0DIEZ)

Drug Name
UNI-rhIL-11 Drug Info
Synonyms Recombinant human interleukin 11 (thrombocytopenia), Uni-Bio Science Group; RhIL-11 (thrombocytopenia), Uni-Bio Science Group
Indication
Disease Entry ICD 11 Status REF
Thrombocytopenia 3B64 Phase 3 [1]
Cross-matching ID
TTD Drug ID
DM0DIEZ

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Interleukin 11 receptor alpha (IL11RA) TTZPLJS I11RA_HUMAN Modulator [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Interleukin 11 receptor alpha (IL11RA) DTT IL11RA 6.248 6.525 4.591 6.246
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 03 Disease of the blood or blood-forming organs
Disease Class ICD-11: 3B64 Thrombocytopenia
The Studied Tissue Whole blood
The Studied Disease Thrombocytopenia [ICD-11:3B64]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Interleukin 11 receptor alpha (IL11RA) DTT IL11RA 1.95E-01 0.44 0.53
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 ClinicalTrials.gov (NCT01663441) A Phase Study of Genetically Modified Recombinant Human Interleukin-11. U.S. National Institutes of Health.
2 Clinical study of rhIL-11 for prevention and treatment of chemotherapy-induced thrombocytopenia. Ai Zheng. 2002 Aug;21(8):892-5.