Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM0LKHV)

• Drug Name: B7-2/GM-CSF Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Dementia	6D80-6D86	Phase 1	[1]
Dyslipidemia	5C80-5C81	Phase 1	[2]
Schizophrenia	6A20	Phase 1	[1]
Solid tumour/cancer	2A00-2F9Z	Phase 1	[3]

• Cross-matching ID:
  PubChem CID: 9862248
  ChEBI ID: CHEBI:79988
  CAS Number: CAS 211110-63-3
  TTD Drug ID: DM0LKHV

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Agonist	[4]
Thyroid hormone receptor (THR)	TTQWUPT	NOUNIPROTAC	Agonist	[5]

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• ICD Disease Classification: 06 Mental, behavioural or neurodevelopmental disorder
• Disease Class: ICD-11: 6A20 Schizophrenia
• The Studied Tissue: Pre-frontal cortex
• The Studied Disease: Schizophrenia [ICD-11:6A20]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M1 (CHRM1)	DTT	CHRM1	8.42E-02	-0.38	-0.24
Muscarinic acetylcholine receptor M1 (CHRM1)	DTT	CHRM1	2.55E-01	0.14	0.37

References

• [1] Trusted, scientifically sound profiles of drug programs, clinical trials, safety reports, and company deals, written by scientists. Springer. 2015. Adis Insight (drug id 800028844)
• [2] URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2639).
• [3] GM-CSF-Secreting Vaccines for Solid Tumors: Moving Forward. Discov Med. 2010 July; 10(50): 52-60.
• [4] Clinical pipeline report, company report or official report of GlaxoSmithKline (2009).
• [5] Sobetirome: a case history of bench-to-clinic drug discovery and development. Heart Fail Rev. 2010 Mar;15(2):177-82.