Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1NG5W)

Drug Name
Hydrogen peroxide Drug Info
Synonyms
perhydrol; oxydol; 7722-84-1; Superoxol; Interox; Hydrogen dioxide; hydroperoxide; Peroxaan; Inhibine; Kastone; Hioxyl; Albone; Albone 35; Dihydrogen dioxide; Albone DS; T-Stuff; Lensept; Perone; Elawox; Albone 70; Perone 50; Albone 50; Albone 35CG; Albone 70CG; Albone 50CG; H2O2; Hydrogen peroxide (H2O2); Peroxide; Peroxan; Hydrogen peroxide, 30%; Hydrogen dioxide solution; Hydrogen peroxide, 90%; Perone 35; Perone 30; Hydrogen peroxide, solution; Waterstofperoxyde; Wasserstoffperoxid; Hydrogen peroxide, 3%; Caswell No. 486AA
Indication
Disease Entry ICD 11 Status REF
Infectious disease 1A00-CA43.1 Approved [1]
Cross-matching ID
PubChem CID
784
ChEBI ID
CHEBI:16240
CAS Number
CAS 7722-84-1
TTD Drug ID
DM1NG5W
INTEDE Drug ID
DR0832

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
PTPN1 messenger RNA (PTPN1 mRNA) TTELIN2 PTN1_HUMAN Inhibitor [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Cytochrome P450 2D6 (CYP2D6) DECB0K3 CP2D6_HUMAN Approved [3]
Cytochrome P450 1B1 (CYP1B1) DE9QHP6 CP1B1_HUMAN Approved [4]
Cellular glutathione peroxidase (GPX1) DESZ5G9 GPX1_HUMAN Approved [5]
Catalase (CAT) DE1XPGH CATA_HUMAN Approved [5]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
PTPN1 messenger RNA (PTPN1 mRNA) DTT PTPN1 3.667 2.293 2.609 4.573
Cellular glutathione peroxidase (GPX1) DME GPX1 9.814 9.005 10.169 8.807
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 3.307 5.005 3.921 5.327
Cytochrome P450 1B1 (CYP1B1) DME CYP1B1 5.098 5.256 8.133 6.2
Catalase (CAT) DME CAT 9.488 7.293 7.69 7.201
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Infectious disease
ICD Disease Classification 1A00-CA43.1
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
PTPN1 messenger RNA (PTPN1 mRNA) DTT PTPN1 9.44E-01 7.21E-03 0.08
Cellular glutathione peroxidase (GPX1) DME GPX1 6.69E-01 2.17E-01 9.80E-01
Cytochrome P450 2D6 (CYP2D6) DME CYP2D6 7.04E-01 -2.88E-01 -5.42E-01
Cytochrome P450 1B1 (CYP1B1) DME CYP1B1 1.55E-03 8.10E-01 2.53E+00
Catalase (CAT) DME CAT 1.65E-01 -1.38E-02 -3.03E-02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 2448).
2 Periodinates: a new class of protein tyrosine phosphatase inhibitors. Bioorg Med Chem Lett. 1999 Feb 8;9(3):353-6.
3 Engineering of cytochrome P450 3A4 for enhanced peroxide-mediated substrate oxidation using directed evolution and site-directed mutagenesis. Drug Metab Dispos. 2006 Dec;34(12):1958-65.
4 NADPH- and hydroperoxide-supported 17beta-estradiol hydroxylation catalyzed by a variant form (432L, 453S) of human cytochrome P450 1B1. J Steroid Biochem Mol Biol. 2000 Sep;74(1-2):11-8.
5 Catalase and glutathione peroxidase are equally active in detoxification of hydrogen peroxide in human erythrocytes. Blood. 1989 Jan;73(1):334-9.