Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM1W7LV)

Drug Name

CAR-T cells targeting MAGE-A1 Drug Info

Indication

Disease Entry	ICD 11	Status	REF
Lung cancer	2C25.0	Phase 1/2	[1]

Cross-matching ID

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Melanoma-associated antigen 1 (MAGEA1)	TT63M7Q	MAGA1_HUMAN	CAR-T-Cell-Therapy	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Melanoma-associated antigen 1 (MAGEA1)	DTT	MAGEA1	1.433	1.536	2.138	2.848

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Lung cancer

ICD Disease Classification

2C25.0

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Melanoma-associated antigen 1 (MAGEA1)	DTT	MAGEA1	6.96E-12	0.59	1.39

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	ClinicalTrials.gov (NCT03356808) Antigen-specific T Cells Against Lung Cancer