Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM27HMT)

Drug Name

4,9-Dihydro-3H-beta-carboline Drug Info

Synonyms

4894-26-2; 4,9-dihydro-3H-Pyrido[3,4-b]indole; 4,9-dihydro-3H-beta-carboline; 3H-Pyrido(3,4-b)indole, 4,9-dihydro-; 3,4-dihydro-beta-carboline; CHEMBL266221; 4,9-Dihydro-3H-pyrido(3,4-b)indole; 3H-Pyrido[3,4-b]indole, 4,9-dihydro-; AC1L3RVU; 3,4-dihydrobeta-carboline; SCHEMBL678673; CTK7D1379; DTXSID20197643; ZINC332024; BDBM50136506; SBB062953; FCH841675; AKOS006272808; ACM4894262; 3H,4H,9H-PYRIDO[3,4-B]INDOLE; TX-010240; FT-0698471

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 145772
CAS Number: CAS 4894-26-2
TTD Drug ID: DM27HMT

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Monoamine oxidase type A (MAO-A)	TT3WG5C	AOFA_HUMAN	Inhibitor	[1]
Monoamine oxidase type B (MAO-B)	TTGP7BY	AOFB_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Monoamine oxidase type B (MAO-B)	DTT	MAOB	9.367	6.907	8.237	8.409
Monoamine oxidase type A (MAO-A)	DTT	MAOA	7.207	8.159	9.043	7.711

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Monoamine oxidase type B (MAO-B)	DTT	MAOB	2.65E-02	1.12E-02	0.07
Monoamine oxidase type A (MAO-A)	DTT	MAOA	8.14E-01	0.05	0.1

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Pyrazino[1,2-a]indoles as novel high-affinity and selective imidazoline I(2) receptor ligands. Bioorg Med Chem Lett. 2004 Feb 23;14(4):1003-5.