Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM2HRKE)

Drug Name

Pentosan Polysulfate Drug Info

Synonyms

Elmiron; Pentosan sulfuric polyester; Polypentose sulfate; Elmiron (TN); Xylan,hydrogen sulfate; [(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfooxyoxan-2-yl]oxy-3-sulfooxyoxan-4-yl] hydrogen sulfate

Indication

Disease Entry	ICD 11	Status	REF
Interstitial cystitis	GC00.3	Approved	[1]
Painful bladder syndrome	MG30.50	Approved	[1]

Therapeutic Class

Anticoagulants

Cross-matching ID

PubChem CID: 37720
CAS Number: CAS 37300-21-3
TTD Drug ID: DM2HRKE
ACDINA Drug ID: D00516

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Fibroblast growth factor-4 (FGF4)	TTCEKVZ	FGF4_HUMAN	Modulator	[2]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Fibroblast growth factor-4 (FGF4)	DTT	FGF4	7.239	6.847	6.564	7.131

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification

16 Disease of the genitourinary system

Disease Class

ICD-11: GA10 Endometriosis

The Studied Tissue

Bladder tissue

The Studied Disease

Interstitial cystitis [ICD-11:GA10]

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Fibroblast growth factor-4 (FGF4)	DTT	FGF4	1.74E-01	0.04	0.45

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020193.
2	Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services.