Details of the Drug
General Information of Drug (ID: DM2HRKE)
Drug Name |
Pentosan polysulfate
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Synonyms |
Elmiron; Pentosan sulfuric polyester; Polypentose sulfate; Elmiron (TN); Xylan,hydrogen sulfate; [(2R,3R,4S,5R)-2-hydroxy-5-[(2S,3R,4S,5R)-5-hydroxy-3,4-disulfooxyoxan-2-yl]oxy-3-sulfooxyoxan-4-yl] hydrogen sulfate
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Indication |
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Therapeutic Class |
Anticoagulants
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Drug Type |
Small molecular drug
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Structure | ||||||||||||||||||||||||
3D MOL | 2D MOL | |||||||||||||||||||||||
#Ro5 Violations (Lipinski): 4 | Molecular Weight (mw) | 602.5 | ||||||||||||||||||||||
Topological Polar Surface Area (xlogp) | -5.6 | |||||||||||||||||||||||
Rotatable Bond Count (rotbonds) | 10 | |||||||||||||||||||||||
Hydrogen Bond Donor Count (hbonddonor) | 6 | |||||||||||||||||||||||
Hydrogen Bond Acceptor Count (hbondacc) | 21 | |||||||||||||||||||||||
ADMET Property | ||||||||||||||||||||||||
Chemical Identifiers |
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Cross-matching ID | ||||||||||||||||||||||||
Molecular Interaction Atlas of This Drug
Drug Therapeutic Target (DTT) |
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Molecular Interaction Atlas (MIA) | |||||||||||||||||||||||||||
Molecular Expression Atlas of This Drug
ICD Disease Classification | 16 Disease of the genitourinary system | |||||||||||||||||||||||
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Disease Class | ICD-11: GA10 Endometriosis | |||||||||||||||||||||||
The Studied Tissue | Bladder tissue | |||||||||||||||||||||||
The Studied Disease | Interstitial cystitis [ICD-11:GA10] | |||||||||||||||||||||||
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Molecular Expression Atlas (MEA) | ||||||||||||||||||||||||
Drug-Drug Interaction (DDI) Information of This Drug
Coadministration of a Drug Treating the Disease Different from Pentosan polysulfate (Comorbidity)
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Drug Inactive Ingredient(s) (DIG) and Formulation(s) of This Drug
References
1 | FDA Approved Drug Products from FDA Official Website. 2009. Application Number: (NDA) 020193. | ||||
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2 | FDA approval: ado-trastuzumab emtansine for the treatment of patients with HER2-positive metastatic breast cancer. Clin Cancer Res. 2014 Sep 1;20(17):4436-41. | ||||
3 | Trend Analysis of a Database of Intravenous Pharmacokinetic Parameters in Humans for 1352 Drug Compounds | ||||
4 | Drugs@FDA. U.S. Food and Drug Administration. U.S. Department of Health & Human Services. | ||||
5 | Angiogenic gene therapy with adenovirus 5 fibroblast growth factor-4 (Ad5FGF-4): a new option for the treatment of coronary artery disease. Am J Cardiol. 2003 Nov 7;92(9B):24N-31N. | ||||
6 | Alferminogene tadenovec, an angiogenic FGF4 gene therapy for coronary artery disease. IDrugs. 2008 Apr;11(4):283-93. | ||||
7 | Effects of Ad5FGF-4 in patients with angina: an analysis of pooled data from the AGENT-3 and AGENT-4 trials. J Am Coll Cardiol. 2007 Sep 11;50(11):1038-46. | ||||
8 | Product Information. Brukinsa (zanubrutinib). BeiGene USA, Inc, San Mateo, CA. | ||||
9 | Product Information. Panhematin (hemin). Recordati Rare Diseases Inc, Lebanon, NJ. | ||||