Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3QDA6)

Drug Name
Polynoma-1 Drug Info
Synonyms Polyvalent melanoma vaccine, Vaccinoma
Indication
Disease Entry ICD 11 Status REF
Melanoma 2C30 Phase 2 [1]
Cross-matching ID
TTD Drug ID
DM3QDA6

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
MART-1 melanoma antigen (MLANA) TT362RB MAR1_HUMAN Not Available [1]
Melanoma-associated antigen 3 (MAGEA3) TTWSKHD MAGA3_HUMAN Not Available [1]
Tyrosinase (TYR) TTULVH8 TYRO_HUMAN Not Available [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Melanoma-associated antigen 3 (MAGEA3) DTT MAGEA3 5.456 3.433 5.396 5.802
Tyrosinase (TYR) DTT TYR 5.959 5.711 5.973 4.912
MART-1 melanoma antigen (MLANA) DTT MLANA 5.361 5.115 4.926 4.954
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Skin
The Studied Disease Melanoma [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Tyrosinase (TYR) DTT TYR 6.68E-04 2.54 1.15
MART-1 melanoma antigen (MLANA) DTT MLANA 3.29E-02 1.64 0.76
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 An immuno-oncology company developing a novel polyvalent antigen therapy for the treatment of melanoma. Polynoma. 2015.