Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3QX0R)

Drug Name
PMID30124346-Compound-60TABLE5 Drug Info
Indication
Disease Entry ICD 11 Status REF
Dyskinesia MB47.4 Patented [1]
Parkinson disease 8A00.0 Patented [2]
Cross-matching ID
TTD Drug ID
DM3QX0R

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Ligand [1]
Adrenergic receptor (ADR) TTVIREA NOUNIPROTAC Ligand [1]
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Ligand [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 1A receptor (HTR1A) DTT HTR1A 4.661 5.289 3.053 3.472
Dopamine D2 receptor (D2R) DTT DRD2 5.345 5.634 5.789 5.901
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Dyskinesia
ICD Disease Classification MB47.4
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 1A receptor (HTR1A) DTT HTR1A 1.49E-05 -0.22 -0.58
Dopamine D2 receptor (D2R) DTT DRD2 2.50E-02 -0.08 -0.49
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 5-HT1A receptor ligands and their therapeutic applications: review of new patents.Expert Opin Ther Pat. 2018 Sep;28(9):679-689.
2 mGlu5 negative allosteric modulators: a patent review (2013 - 2016).Expert Opin Ther Pat. 2017 Jun;27(6):691-706.