Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3XRJT)

Drug Name

PRAVADOLINE Drug Info

Synonyms

Pravadoline; 92623-83-1; (4-Methoxyphenyl)(2-methyl-1-(2-morpholinoethyl)-1H-indol-3-yl)methanone; UNII-P3JW662TWA; WIN 48098; P3JW662TWA; CHEMBL13178; NCGC00160396-01; DSSTox_RID_81361; DSSTox_CID_26127; DSSTox_GSID_46127; Pravadoline, Pravadoline Maleate; Pravadolina; Pravadolinum; (4-methoxyphenyl)-[2-methyl-1-(2-morpholin-4-ylethyl)indol-3-yl]methanone; SMR001550504; Pravadoline [INN]; CAS-92623-83-1; Pravadolinum [INN-Latin]; Pravadolina [INN-Spanish]; AC1Q5EGD; MLS006010335; MLS004774040; SCHEMBL488940; Pravadoline(WIN 48 09

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 56463
CAS Number: CAS 92623-83-1
TTD Drug ID: DM3XRJT

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Cannabinoid receptor 1 (CB1)	TT6OEDT	CNR1_HUMAN	Inhibitor	[1]
Cannabinoid receptor 2 (CB2)	TTMSFAW	CNR2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Cannabinoid receptor 2 (CB2)	DTT	CNR2	7.037	6.733	6.944	7.163
Cannabinoid receptor 1 (CB1)	DTT	CNR1	2.907	4.667	2.982	3.678

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Cannabinoid receptor 1 (CB1)	DTT	CNR1	5.59E-02	-0.22	-0.45
Cannabinoid receptor 1 (CB1)	DTT	CNR1	7.68E-01	-0.06	-0.46

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Morpholinoalkylindenes as antinociceptive agents: Novel cannabinoid receptor agonists, Bioorg. Med. Chem. Lett. 5(4):381-386 (1995).