Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM3YH4I)

Drug Name
D-Serine Drug Info
Synonyms
D-serine; 312-84-5; (R)-2-amino-3-hydroxypropanoic acid; (2R)-2-amino-3-hydroxypropanoic acid; Serine D-form; (R)-Serine; Serine, D-; d-(+)-serine; D-2-Amino-3-hydroxypropionic Acid; D-Serin; D-Ser; UNII-1K77H2Z9B1; EINECS 206-229-4; MFCD00004269; NSC 77689; (2R)-2-amino-3-hydroxy-propanoic acid; AI3-18476; CHEMBL285123; CHEBI:16523; MTCFGRXMJLQNBG-UWTATZPHSA-N; 1K77H2Z9B1; (R)-2-Amino-3-hydroxypropionic acid; DSN; NCGC00094363-03; D-Serine, 98%; D-2-Amino-3-hydroxypropanoic acid; NSC77689; serine d-; [3h]-d-serine; (2R)-serine
Cross-matching ID
PubChem CID
71077
ChEBI ID
CHEBI:16523
CAS Number
CAS 312-84-5
TTD Drug ID
DM3YH4I
VARIDT Drug ID
DR00047
INTEDE Drug ID
DR1922

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Glutamate receptor ionotropic NMDA 1 (NMDAR1) TTLD29N NMDZ1_HUMAN Inhibitor [1]
Strychnine-binding glycine receptor (GLRA1) TTF45NW GLRA1_HUMAN Inhibitor [1]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Alanine/serine/cysteine/threonine transporter 1 (SLC1A4) DTC54PX SATT_HUMAN Phase 4 [2]
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTW7AE3 AAAT_HUMAN Phase 4 [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
D-amino-acid oxidase (DAO) DERZQ2Y OXDA_HUMAN Phase 4 [3]
Serine racemase (SRR) DEKOQX7 SRR_HUMAN Phase 4 [4]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Glutamate receptor ionotropic NMDA 1 (NMDAR1) DTT GRIN1 3.828 2.744 3.392 3.307
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTP ASCT2 5.096 5.661 6.435 5.113
Alanine/serine/cysteine/threonine transporter 1 (SLC1A4) DTP ASCT1 6.684 6.087 6.002 6.201
D-amino-acid oxidase (DAO) DME DAO 8.208 6.176 6.616 6.158
Serine racemase (SRR) DME SRR 5.411 6.064 6.35 6.32
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Alanine/serine/cysteine/threonine transporter 2 (SLC1A5) DTP ASCT2 9.03E-01 2.99E-01 6.85E-01
Alanine/serine/cysteine/threonine transporter 1 (SLC1A4) DTP ASCT1 3.44E-01 1.94E-01 3.02E-01
D-amino-acid oxidase (DAO) DME DAO 1.85E-01 2.08E-01 1.02E+00
Serine racemase (SRR) DME SRR 6.64E-01 9.51E-03 4.57E-02
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Therapeutic Target Database. Nucleic Acids Res. 2002 Jan 1;30(1):412-5.
2 D-Serine Is a Substrate for Neutral Amino Acid Transporters ASCT1/SLC1A4 and ASCT2/SLC1A5, and Is Transported by Both Subtypes in Rat Hippocampal Astrocyte Cultures. PLoS One. 2016 Jun 7;11(6):e0156551.
3 Focus on the role of D-serine and D-amino acid oxidase in amyotrophic lateral sclerosis/motor neuron disease (ALS). Front Mol Biosci. 2018 Feb 13;5:8.
4 D-Serine made by serine racemase in Drosophila intestine plays a physiological role in sleep. Nat Commun. 2019 May 7;10(1):1986.