Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM4EY5S)

Drug Name
2,4-dichloro-5-sulfamoylbenzoic acid Drug Info
Synonyms
2,4-Dichloro-5-sulfamoylbenzoic acid; 2736-23-4; Lasamide; 5-(Aminosulfonyl)-2,4-dichlorobenzoic acid; 2,4-Dichloro-5-sulfamoyl-benzoic acid; 2,4-Dichloro-5-sulphamoylbenzoic acid; UNII-LEG53TF0SN; 2,4-Dichloro-5-sulfamylbenzoic acid; Benzoic acid, 5-(aminosulfonyl)-2,4-dichloro-; EINECS 220-358-3; LEG53TF0SN; 3-Sulfamoyl-4,6-dichlorobenzoic acid; BENZOIC ACID, 2,4-DICHLORO-5-SULFAMOYL-; BRN 2219046; 5-Carboxy-2,4-dichlorobenzenesulfonamide; 5-Aminosulfonyl-2,4-dichlorobenzoic acid; M 12325
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
17655
CAS Number
CAS 2736-23-4
TTD Drug ID
DM4EY5S

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis, characterization and antiglaucoma activity of a novel proton transfer compound and a mixed-ligand Zn(II) complex. Bioorg Med Chem. 2010 Jan 15;18(2):930-8.