Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5IUN8)

Drug Name
12B9m Drug Info
Indication
Disease Entry ICD 11 Status REF
Anaemia 3A90 Preclinical [1]
Cross-matching ID
TTD Drug ID
DM5IUN8

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Hepcidin (HAMP) TTPCG5T HEPC_HUMAN Inhibitor [2]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Hepcidin (HAMP) DTT HAMP 10.14 3.018 4.372 4.315
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Anaemia
ICD Disease Classification 3A90
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Hepcidin (HAMP) DTT HAMP 5.37E-01 0.18 0.47
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Targeting iron metabolism in drug discovery and delivery. Nat Rev Drug Discov. 2017 Jun;16(6):400-423.
2 Pharmacokinetics of anti-hepcidin monoclonal antibody Ab 12B9m and hepcidin in cynomolgus monkeys. AAPS J. 2010 Dec;12(4):646-57.