Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5RE71)

• Drug Name: 1-(2-Chloro-phenyl)-piperazine Drug Info
• Synonyms: 1-(2-Chlorophenyl)piperazine; 39512-50-0; 1-(2-Chloro-phenyl)-piperazine; Piperazine, 1-(2-chlorophenyl)-; CHEMBL9841; 1-(2-chlorophenyl) piperazine; PWZDJIUQHUGFRJ-UHFFFAOYSA-N; 1-(o-CHLOROPHENYL)PIPERAZINE; (2-chlorophenyl)piperazine; Chlorphenylpiperazin; EINECS 254-480-3; PubChem14571; AC1Q3KEP; ACMC-1AIF1; ortho-chlorophenylpiperazine; AC1L9A0W; DSSTox_RID_97408; DSSTox_CID_31523; N-(o-Chlorophenyl)piperazine; DSSTox_GSID_57734; N-(2-Chlorophenyl)piperazine; KSC224M6P; SCHEMBL230424; N-(o-chlorophenyl)-piperazine

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 415628
  CAS Number: CAS 39512-50-0
  TTD Drug ID: DM5RE71

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
5-HT 1A receptor (HTR1A)	TTSQIFT	5HT1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1A (ADRA1A)	TTNGILX	ADA1A_HUMAN	Inhibitor	[1]
Adrenergic receptor alpha-1D (ADRA1D)	TT34BHT	ADA1D_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
5-HT 1A receptor (HTR1A)	DTT	HTR1A	4.661	5.289	3.053	3.472
Adrenergic receptor alpha-1A (ADRA1A)	DTT	ADRA1A	3.154	3.853	4.129	2.963

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
5-HT 1A receptor (HTR1A)	DTT	HTR1A	2.18E-01	-0.11	-0.51

References

• [1] Pyrimido[5,4-b]indole derivatives. 1. A new class of potent and selective alpha 1 adrenoceptor ligands. J Med Chem. 1991 Jun;34(6):1850-4.