Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM5XMI9)

Drug Name
4-Methylamino-benzenesulfonamide Drug Info
Synonyms
4-(Methylamino)Benzenesulfonamide; 4-(methylamino)benzene-1-sulfonamide; 16891-79-5; 4-Methylamino-benzenesulfonamide; CHEMBL174847; AC1Q40XN; SCHEMBL3521509; p-methylaminobenzene sulphonamide; CTK4D3153; DTXSID40562172; FJVAYUUWTJKKNC-UHFFFAOYSA-N; MolPort-004-759-881; Benzenesulfonamide,4-(methylamino)-; ZINC28098746; BDBM50160668; Benzenesulfonamide, 4-(methylamino)-; AKOS009323835; MCULE-7909074599; NE62186; DA-09438; KB-289209; FT-0749810; EN300-58198
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
14612854
CAS Number
CAS 16891-79-5
TTD Drug ID
DM5XMI9

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]
Carbonic anhydrase XII (CA-XII) TTSYM0R CAH12_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase XII (CA-XII) DTT CA12 6.015 9.06 10.222 5.773
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase XII (CA-XII) DTT CA12 3.29E-21 1.27 1.02
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Carbonic anhydrase inhibitors. Inhibition of the transmembrane isozyme XII with sulfonamides-a new target for the design of antitumor and antiglauc... Bioorg Med Chem Lett. 2005 Feb 15;15(4):963-9.