Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM6WYGC)

Drug Name
Sodium trithiocarbonate Drug Info
Synonyms
Sodium trithiocarbonate; Carbonotrithioic acid, disodium salt; disodium carbonotrithioate; UNII-Y01PT1AS4O; 534-18-9; Y01PT1AS4O; Carbonotrithioic acid, sodium salt (1:2); CHEMBL471245; EINECS 208-592-4; Sodium Carbonotrithioate; disodium trithiocarbonate; AC1Q1UXB; AC1L2RHE; AC1MC2O4; SCHEMBL1492384; DTXSID7060203; Trithiocarbonic acid disodium salt; USAIOOFEIMNEDN-UHFFFAOYSA-L; AKOS006229270; AN-21294
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
101753
CAS Number
CAS 534-18-9
TTD Drug ID
DM6WYGC

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]
Carbonic anhydrase IV (CA-IV) TTZHA0O CAH4_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase IV (CA-IV) DTT CA4 1.58E-77 -2.02 -1.77
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Carbonic anhydrase inhibitors. Inhibition of cytosolic isoforms I, II, III, VII and XIII with less investigated inorganic anions. Bioorg Med Chem Lett. 2009 Apr 1;19(7):1855-7.