Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM76GZ0)

Drug Name
Angiotensin-(1-7) Drug Info
Synonyms Ang (1-7); Angiotensin (1-7); Angiotensin-(1-7) (cancer); Angiotensin-(1-7) (cancer), Wake Forest University
Indication
Disease Entry ICD 11 Status REF
Sarcoma 2A60-2C35 Phase 3 [1]
Chemotherapy-induced nausea MD90 Phase 2 [2]
Duchenne dystrophy 8C70 Phase 2 [3]
Lymphoma 2A80-2A86 Phase 2 [2]
Muscular dystrophy 8C70 Phase 1 [3]
Cross-matching ID
PubChem CID
123805
ChEBI ID
CHEBI:55438
CAS Number
CAS 39386-80-6
TTD Drug ID
DM76GZ0
INTEDE Drug ID
DR1903

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Proto-oncogene Mas (MAS) TTOISYB MAS_HUMAN Agonist [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Angiotensin-converting enzyme 2 (ACE2) DEGPI81 ACE2_HUMAN Phase 3 [5]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Proto-oncogene Mas (MAS) DTT MAS1 6.09 4.358 6.274 6.248
Angiotensin-converting enzyme 2 (ACE2) DME ACE2 5.213 5.722 6.793 9.692
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

ICD Disease Classification 02 Neoplasm
Disease Class ICD-11: 2C82 Prostate cancer
The Studied Tissue Muscle tissue
The Studied Disease Sarcoma [ICD-11:2C82]
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Proto-oncogene Mas (MAS) DTT MAS1 2.91E-75 -0.43 -1.38
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 582).
2 ClinicalTrials.gov (NCT01121120) Acceleration of Platelet Recovery Following Autologous Peripheral Blood Stem Cell Transplant (PBSC) in Hodgkin, Non-Hodgkin Lymphoma or Multiple Myeloma Patients. U.S. National Institutes of Health.
3 Clinical pipeline report, company report or official report of the Pharmaceutical Research and Manufacturers of America (PhRMA)
4 New therapeutic pathways in the RAS. J Renin Angiotensin Aldosterone Syst. 2012 Dec;13(4):505-8.
5 Metabolism of angiotensin-(1-7) by angiotensin-converting enzyme. Hypertension. 1998 Jan;31(1 Pt 2):362-7.