Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7UK56)

Drug Name

1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3) Drug Info

Synonyms

FPP 028; 86969-15-5; BRN 5552278; 4-Ethyl-4,7-dihydro-2-phenylpyrazolo(1,5-a)pyrimidin-7-one; FPP-028; 4-Ethyl-2-phenyl-pyrazolo(1,5-a)pyrimidin-7(4H)-one; 4,7-Dihydro-4-ethyl-2-phenyl-pyrazolo(1,5-a)pyrimidin-7-one; Pyrazolo(1,5-a)pyrimidin-7(4H)-one, 4-ethyl-2-phenyl-; AC1Q6I4H; CHEMBL45806; AC1L375B; 4-ethyl-2-phenylpyrazolo[1,5-a]pyrimidin-7(4h)-one; CTK5F7460; DTXSID70236016; ZINC5957034; LS-129307; 4-ethyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 135819
CAS Number: CAS 86969-15-5
TTD Drug ID: DM7UK56

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.966	5.133	5.358	6.128

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	The anti-angiogenic effects of 1-furan-2-yl-3-pyridin-2-yl-propenone are mediated through the suppression of both VEGF production and VEGF-induced ... Vascul Pharmacol. 2009 Mar-Apr;50(3-4):123-31.