Details of the Drug

General Information of Drug (ID: DM7UK56)

• Drug Name: 1-furan-2-yl-3-pyridin-2-yl-propenone (FPP-3)
• Synonyms: FPP 028; 86969-15-5; BRN 5552278; 4-Ethyl-4,7-dihydro-2-phenylpyrazolo(1,5-a)pyrimidin-7-one; FPP-028; 4-Ethyl-2-phenyl-pyrazolo(1,5-a)pyrimidin-7(4H)-one; 4,7-Dihydro-4-ethyl-2-phenyl-pyrazolo(1,5-a)pyrimidin-7-one; Pyrazolo(1,5-a)pyrimidin-7(4H)-one, 4-ethyl-2-phenyl-; AC1Q6I4H; CHEMBL45806; AC1L375B; 4-ethyl-2-phenylpyrazolo[1,5-a]pyrimidin-7(4h)-one; CTK5F7460; DTXSID70236016; ZINC5957034; LS-129307; 4-ethyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-one

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Drug Type: Small molecular drug
• #Ro5 Violations (Lipinski): 0:
  Molecular Weight (mw); 239.27
  Logarithm of the Partition Coefficient (xlogp); 2.5
  Rotatable Bond Count (rotbonds); 2
  Hydrogen Bond Donor Count (hbonddonor); 0
  Hydrogen Bond Acceptor Count (hbondacc); 3
• Chemical Identifiers:
  Formula: C14H13N3O
  IUPAC Name: 4-ethyl-2-phenylpyrazolo[1,5-a]pyrimidin-7-one
  Canonical SMILES: CCN1C=CC(=O)N2C1=CC(=N2)C3=CC=CC=C3
  InChI: InChI=1S/C14H13N3O/c1-2-16-9-8-14(18)17-13(16)10-12(15-17)11-6-4-3-5-7-11/h3-10H,2H2,1H3
  InChIKey: JEWOUZIOCRUZPT-UHFFFAOYSA-N
• Cross-matching ID:
  PubChem CID: 135819
  CAS Number: 86969-15-5
  TTD ID: D0B0XK

Molecular Interaction Atlas of This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Arachidonate 5-lipoxygenase (5-LOX)	TT2J34L	LOX5_HUMAN	Inhibitor	[1]

Molecular Expression Atlas of This Drug

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Arachidonate 5-lipoxygenase (5-LOX)	DTT	ALOX5	4.15E-01	-0.06	-0.15

References

• [1] The anti-angiogenic effects of 1-furan-2-yl-3-pyridin-2-yl-propenone are mediated through the suppression of both VEGF production and VEGF-induced ... Vascul Pharmacol. 2009 Mar-Apr;50(3-4):123-31.