Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM7V025)

Drug Name
N-Phenyl-1H-indole-2-carboxamide Drug Info
Synonyms
N-Phenyl-1H-indole-2-carboxamide; Indole, derivative of; 1H-Indole-2-carboxamide, N-phenyl-; CHEMBL454487; 17954-05-1; Indole-2-carboxanilide; AC1LBUC7; MLS000701794; SCHEMBL7208136; CTK0E3276; DTXSID20343340; MolPort-001-788-903; ARBMSJKZZZWLOE-UHFFFAOYSA-N; HMS2544M17; ZINC384465; BDBM50273485; N-Phenyl-1H-indole-2-carboxamide #; AKOS008463534; MCULE-4430477478; SMR000229823; AB00566179-06; AP-122/41076197
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
589138
CAS Number
CAS 17954-05-1
TTD Drug ID
DM7V025

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Monoamine oxidase type A (MAO-A) TT3WG5C AOFA_HUMAN Inhibitor [1]
Monoamine oxidase type B (MAO-B) TTGP7BY AOFB_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Monoamine oxidase type B (MAO-B) DTT MAOB 9.367 6.907 8.237 8.409
Monoamine oxidase type A (MAO-A) DTT MAOA 7.207 8.159 9.043 7.711
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Monoamine oxidase type B (MAO-B) DTT MAOB 2.65E-02 1.12E-02 0.07
Monoamine oxidase type A (MAO-A) DTT MAOA 8.14E-01 0.05 0.1
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Synthesis, structure-activity relationships and molecular modeling studies of new indole inhibitors of monoamine oxidases A and B. Bioorg Med Chem. 2008 Nov 15;16(22):9729-40.