Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM823CD)

Drug Name

2-(4-Diethylamino-but-2-ynyl)-isoindole-1,3-dione Drug Info

Synonyms

CHEMBL176400; F2147-1072; 7351-91-9; 2-(4-Diethylamino-but-2-ynyl)-isoindole-1,3-dione; SCHEMBL14676513; MolPort-023-212-106; DEWGBLHKQDVWLX-UHFFFAOYSA-N; BDBM50291598; ZINC28090831; AKOS024627738; MCULE-2799628954; 2-(4-(diethylamino)but-2-yn-1-yl)isoindoline-1,3-dione

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 44385509
TTD Drug ID: DM823CD

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Muscarinic acetylcholine receptor M1 (CHRM1)	TTZ9SOR	ACM1_HUMAN	Inhibitor	[1]
Muscarinic acetylcholine receptor M2 (CHRM2)	TTYEG6Q	ACM2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Muscarinic acetylcholine receptor M1 (CHRM1)	DTT	CHRM1	5.59E-01	0.19	0.41
Muscarinic acetylcholine receptor M2 (CHRM2)	DTT	CHRM2	5.59E-01	0.19	0.41

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Design of dual acting anticonvulsant-antimuscarinic succinimide and hydantoin derivatives, Bioorg. Med. Chem. Lett. 7(8):979-984 (1997).