Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM83951)

Drug Name

AG-E-85378 Drug Info

Synonyms

N-(4-Chlorophenyl)-2-[(pyridin-4-ylmethyl)amino]benzamide; 269390-69-4; VEGFR Tyrosine Kinase Inhibitor II; VEGF Receptor Tyrosine Kinase Inhibitor II; CHEMBL101683; 3hng; AG-E-85378; ZINC8732; SCHEMBL3005186; GTPL6056; N-(4-chlorophenyl)-2-(pyridin-4-ylmethylamino)benzamide; CTK4F8762; DTXSID60430900; MolPort-044-561-457; HMS3229O07; IN1017; BDBM50132151; AKOS030580576; DB07288; CCG-206804; NCGC00387770-01; ACM269390694; RT-016223; KB-299355; J-016613; N-(4-Chlorophenyl)-2-(4-pyridinylmethylamino)benzamide

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 9797919
CAS Number: CAS 269390-69-4
TTD Drug ID: DM83951

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Vascular endothelial growth factor receptor 2 (KDR)	TTUTJGQ	VGFR2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Vascular endothelial growth factor receptor 2 (KDR)	DTT	KDR	1.98E-01	0.11	0.2

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Discovery of N-phenyl nicotinamides as potent inhibitors of Kdr. Bioorg Med Chem Lett. 2007 Nov 1;17(21):6003-8.