Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM86HTZ)

Drug Name

2-Hydroxycinnamic acid Drug Info

Synonyms

2-Hydroxy Cinnamic Acid; 3-(2-hydroxyphenyl)prop-2-enoic acid; Orthocumarsaure; ACMC-1BBQC; AC1L1YJR; 2-HYDROXYCINNAMICACID; CTK1F7842; CTK1H2007; CTK1B5135; PMOWTIHVNWZYFI-UHFFFAOYSA-N; MolPort-006-109-312; HMS3604C08; KS-00000X9C; EINECS 209-500-5; AKOS026677434; MCULE-7485332494; SY048367; FT-0612592; FT-0612591; MFCD00004379 (97%); 2-Propenoic acid, 3-(hydroxyphenyl)-, (Z)-; 2-Propenoic acid, 3-(hydroxyphenyl)-, (2E)-; 38094-41-6

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 637540
ChEBI ID: CHEBI:18125
CAS Number: CAS 614-60-8
TTD Drug ID: DM86HTZ

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Carbonic anhydrase inhibitors. Antioxidant polyphenols effectively inhibit mammalian isoforms I-XV. Bioorg Med Chem Lett. 2010 Sep 1;20(17):5050-3.