Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM8C3GN)

Drug Name
Denopamine Drug Info
Synonyms Kalgut (TN)
Indication
Disease Entry ICD 11 Status REF
Cardiac disease BA00-BE2Z Approved [1]
Cross-matching ID
PubChem CID
5311064
ChEBI ID
CHEBI:135359
CAS Number
CAS 71771-90-9
TTD Drug ID
DM8C3GN
VARIDT Drug ID
DR00901
INTEDE Drug ID
DR1970

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Dopamine D2 receptor (D2R) TTEX248 DRD2_HUMAN Modulator [2]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
UDP-glucuronosyltransferase 2B17 (UGT2B17) DEAZDL8 UDB17_HUMAN Phase 4 [3]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Dopamine D2 receptor (D2R) DTT DRD2 5.345 5.634 5.789 5.901
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME UGT2B17 7.667 8.992 1.322 9.125
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Cardiac disease
ICD Disease Classification BA00-BE2Z
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Dopamine D2 receptor (D2R) DTT DRD2 2.50E-02 -0.08 -0.49
UDP-glucuronosyltransferase 2B17 (UGT2B17) DME UGT2B17 1.78E-02 2.50E-02 1.84E-01
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 534).
2 Natural products as sources of new drugs over the last 25 years. J Nat Prod. 2007 Mar;70(3):461-77.
3 Regioselective glucuronidation of denopamine: marked species differences and identification of human udp-glucuronosyltransferase isoform. Drug Metab Dispos. 2005 Mar;33(3):403-12.