Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM90LWT)

Drug Name

1-Methyl-3-propyl-3,7-dihydro-purine-2,6-dione Drug Info

Synonyms

Xanthine, 1-methyl-3-propyl-; 1-methyl-3-propyl-7H-purine-2,6-dione; CHEMBL286976; 118024-67-2; 1H-Purine-2,6-dione, 3,7-dihydro-1-methyl-3-propyl-; 1H-Purine-2,6-dione,3,9-dihydro-3-methyl-1-propyl-; AC1L3BCB; 1-Methyl-3-propyl-3,7-dihydro-purine-2,6-dione; SCHEMBL9765669; CTK5D5561; ZINC4770328; BDBM50001509; AKOS030229248

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

Cross-matching ID

PubChem CID: 86344
ChEBI ID: CHEBI:145517
CAS Number: CAS 118024-67-2
TTD Drug ID: DM90LWT

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 4A (PDE4A)	TTZ97H5	PDE4A_HUMAN	Inhibitor	[1]
Phosphodiesterase 4D (PDE4D)	TTSKMI8	PDE4D_HUMAN	Inhibitor	[1]

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The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phosphodiesterase 4A (PDE4A)	DTT	PDE4A	4.1	2.787	2.379	3.433

Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease

Discovery agent

ICD Disease Classification

N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 4A (PDE4A)	DTT	PDE4A	9.26E-01	-3.01E-03	-0.01

Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1	Effects of alkyl substitutions of xanthine skeleton on bronchodilation. J Med Chem. 1992 Oct 30;35(22):4039-44.