Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9GOTA)

Drug Name
4-(2-Phenylacetamido)-3-chlorobenzenesulfonamide Drug Info
Synonyms
BRN 2157920; N-(4-(Aminosulfonyl)-2-chlorophenyl)benzeneacetamide; 3-Chloro-4-phenacetamido-benzenesulfonamide; Benzeneacetamide, N-(4-(aminosulfonyl)-2-chlorophenyl)-; 68252-75-5; AC1MHICQ; sulfonamide deriv., 7e; SCHEMBL8222515; CHEMBL583971; CTK5C7613; BDBM35737; DTXSID70218418; LS-28479; 3-Chloro-4-(phenylacetylamino)benzenesulfonamide
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
3051968
CAS Number
CAS 68252-75-5
TTD Drug ID
DM9GOTA

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Carbonic anhydrase (CA) TTUNARX NOUNIPROTAC Inhibitor [1]
Carbonic anhydrase I (CA-I) TTHQPL7 CAH1_HUMAN Inhibitor [1]
Carbonic anhydrase II (CA-II) TTANPDJ CAH2_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Carbonic anhydrase I (CA-I) DTT CA1 5.564 11.952 6.146 7.235
Carbonic anhydrase II (CA-II) DTT CA2 8.796 10.933 9.395 9.819
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Carbonic anhydrase I (CA-I) DTT CA1 5.23E-14 -0.11 -0.41
Carbonic anhydrase II (CA-II) DTT CA2 7.95E-08 0.52 0.33
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 Carbonic anhydrase inhibitors. Aromatic/heterocyclic sulfonamides incorporating phenacetyl, pyridylacetyl and thienylacetyl tails act as potent inh... Bioorg Med Chem. 2009 Jul 15;17(14):4894-9.