Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DM9GRN8)

• Drug Name: 1-Butyl-3-methyl-3,7-dihydro-purine-2,6-dione Drug Info
• Synonyms: CHEMBL130503; 1-Butyl-3-methyl-3,7-dihydro-purine-2,6-dione; SCHEMBL7109948; 1H-Purine-2,6-dione, 1-butyl-3,9-dihydro-3-methyl-; XT-56; BDBM50001494

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 12905389
  TTD Drug ID: DM9GRN8

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Phosphodiesterase 4A (PDE4A)	TTZ97H5	PDE4A_HUMAN	Inhibitor	[1]
Phosphodiesterase 4D (PDE4D)	TTSKMI8	PDE4D_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Phosphodiesterase 4A (PDE4A)	DTT	PDE4A	4.1	2.787	2.379	3.433

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Phosphodiesterase 4A (PDE4A)	DTT	PDE4A	9.26E-01	-3.01E-03	-0.01

References

• [1] Effects of alkyl substitutions of xanthine skeleton on bronchodilation. J Med Chem. 1992 Oct 30;35(22):4039-44.