Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMAO80I)

Drug Name
Pralatrexate Drug Info
Synonyms Folotyn (TN)
Indication
Disease Entry ICD 11 Status REF
Breast cancer 2C60-2C65 Approved [1]
Peripheral T-cell lymphoma 2A90.C Approved [1]
Primary cutaneous peripheral T-cell lymphoma not otherwise specified Approved [2]
Cross-matching ID
PubChem CID
148121
ChEBI ID
CHEBI:71223
CAS Number
CAS 146464-95-1
TTD Drug ID
DMAO80I
VARIDT Drug ID
DR00041
INTEDE Drug ID
DR1320
ACDINA Drug ID
D01353

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
Polypeptide deformylase (PDF) TT9SL3Q DEFM_HUMAN Inhibitor [3]

Drug Transporter (DTP)
DTP Name DTP ID UniProt ID Highest Status REF
Folate transporter 1 (SLC19A1) DTOSN46 S19A1_HUMAN Approved [4]
Proton-coupled folate transporter (SLC46A1) DTDJEMI PCFT_HUMAN Approved [4]

Drug-Metabolizing Enzyme (DME)
DME Name DME ID UniProt ID Highest Status REF
Folylpolyglutamate synthase (FPGS) DECWT2V FOLC_HUMAN Approved [5]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Folate transporter 1 (SLC19A1) DTP FLOT1 5.536 4.129 3.818 6.44
Folylpolyglutamate synthase (FPGS) DME FPGS 7.887 6.284 7.086 6.635
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Breast cancer
ICD Disease Classification 2C60-2C65
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Polypeptide deformylase (PDF) DTT PDF 8.87E-16 -0.54 -0.86
Folate transporter 1 (SLC19A1) DTP FLOT1 3.94E-04 -1.44E-01 -3.83E-01
Proton-coupled folate transporter (SLC46A1) DTP PCFT 2.13E-02 -3.56E-02 -2.38E-01
Folylpolyglutamate synthase (FPGS) DME FPGS 4.94E-49 5.45E-01 1.87E+00
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 URL: http://www.guidetopharmacology.org Nucleic Acids Res. 2015 Oct 12. pii: gkv1037. The IUPHAR/BPS Guide to PHARMACOLOGY in 2016: towards curated quantitative interactions between 1300 protein targets and 6000 ligands. (Ligand id: 6840).
2 Pralatrexate FDA Label
3 Hughes B: 2009 FDA drug approvals. Nat Rev Drug Discov. 2010 Feb;9(2):89-92.
4 Antifolates in cancer therapy: structure, activity and mechanisms of drug resistance. Drug Resist Updat. 2012 Aug;15(4):183-210.
5 Pralatrexate : evaluation of clinical efficacy and toxicity in T-cell lymphoma. Expert Opin Pharmacother. 2013 Mar;14(4):515-23.