Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMB49UP)

Drug Name
2-(4-Bromo-phenyl)-1-methyl-ethylamine Drug Info
Synonyms
1-(4-bromophenyl)propan-2-amine; 13235-83-1; 4-bromoamphetamine; Para-Bromoamphetamine; BRN 3240553; Benzeneethanamine, 4-bromo-alpha-methyl-, (+-)-; 2-(4-Bromo-phenyl)-1-methyl-ethylamine; CHEMBL61355; (+-)-4-Bromo-alpha-methylbenzeneethanamine; 18455-37-3; 1-(4-Bromobenzyl)ethylamine; 4-Ba; AC1L4F4G; 3-12-00-02675 (Beilstein Handbook Reference); SCHEMBL164716; CTK0I1684; SMNXUMMCCOZPPN-UHFFFAOYSA-N; 1-(4-bromophenyl)propane-2-amine; BDBM50005252; AKOS022180693; AKOS000160383; 1-Methyl-2-(4-bromophenyl)ethanamine
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
205668
CAS Number
CAS 13235-83-1
TTD Drug ID
DMB49UP

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
5-HT 1A receptor (HTR1A) TTSQIFT 5HT1A_HUMAN Inhibitor [1]
5-HT 1D receptor (HTR1D) TT6MSOK 5HT1D_HUMAN Inhibitor [1]
5-HT 2A receptor (HTR2A) TTJQOD7 5HT2A_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
5-HT 1A receptor (HTR1A) DTT HTR1A 4.661 5.289 3.053 3.472
5-HT 2A receptor (HTR2A) DTT HTR2A 4.84 4.904 4.652 4.129
5-HT 1D receptor (HTR1D) DTT HTR1D 3.307 1.263 2.585 5.833
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
5-HT 1A receptor (HTR1A) DTT HTR1A 2.18E-01 -0.11 -0.51
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 5-HT1 and 5-HT2 binding characteristics of 1-(2,5-dimethoxy-4-bromophenyl)-2-aminopropane analogues. J Med Chem. 1986 Feb;29(2):194-9.