Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMBK67H)

• Drug Name: 4-isothiocyanatobenzenesulfonamide Drug Info
• Synonyms: 4-Isothiocyanatobenzenesulfonamide; 51908-29-3; 4-isothiocyanatobenzene-1-sulfonamide; 4-Isothiocyanato-benzenesulfonamide; Benzenesulfonamide, 4-isothiocyanato-; CHEMBL144818; IMDUFDNFSJWYQT-UHFFFAOYSA-N; 4-Isothiocyanatobenzene sulfonamide; 4-Icsa; AC1LAVHK; SCHEMBL1476527; CTK4J5100; DTXSID90199871; MolPort-000-156-692; KS-00000HK9; ZINC2571868; ALBB-003064; 4-(Isothiocyanato)benzenesulfonamide; Benzenesulfonamide,4-isothiocyanato-; GEO-03379; BDBM50094812; ANW-51072; STK501629; 4-(aminosulfonyl)phenylisothiocyanate; SBB046978

Indication

Disease Entry	ICD 11	Status	REF
Discovery agent	N.A.	Investigative	[1]

• Cross-matching ID:
  PubChem CID: 521359
  CAS Number: CAS 51908-29-3
  TTD Drug ID: DMBK67H

Molecule(s) Related to This Drug

Drug Therapeutic Target (DTT)

DTT Name	DTT ID	UniProt ID	MOA	REF
Carbonic anhydrase I (CA-I)	TTHQPL7	CAH1_HUMAN	Inhibitor	[1]
Carbonic anhydrase II (CA-II)	TTANPDJ	CAH2_HUMAN	Inhibitor	[1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule	Molecule Type	Gene Name	Liver	Colon	Kidney	Small Intestine
Carbonic anhydrase I (CA-I)	DTT	CA1	5.564	11.952	6.146	7.235
Carbonic anhydrase II (CA-II)	DTT	CA2	8.796	10.933	9.395	9.819

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

• The Studied Disease: Discovery agent
• ICD Disease Classification: N.A.

Molecule Name	Molecule Type	Gene Name	p-value	Fold-Change	Z-score
Carbonic anhydrase I (CA-I)	DTT	CA1	5.23E-14	-0.11	-0.41
Carbonic anhydrase II (CA-II)	DTT	CA2	7.95E-08	0.52	0.33

References

• [1] Carbonic anhydrase inhibitors: the first on-resin screening of a 4-sulfamoylphenylthiourea library. J Med Chem. 2004 Oct 7;47(21):5224-9.