Details of the Drug-Related molecule(s) Expression Atlas

General Information of Drug (ID: DMCAR7B)

Drug Name
O-Sialic Acid Drug Info
Synonyms
alpha-Neu5Ac; N-acetyl-alpha-neuraminic acid; O-sialic acid; CHEBI:49026; N-Acetyl-a-neuraminic acid; UNII-04A90EXP8V; sialic acid; 04A90EXP8V; N-acetyl-alpha-neuraminate; NANA; 5-acetamido-3,5-dideoxy-D-glycero-alpha-D-galacto-non-2-ulopyranosonic acid; 131-48-6; SIA; (2R,4S,5R,6R)-5-acetamido-2,4-dihydroxy-6-[(1R,2R)-1,2,3-trihydroxypropyl]oxane-2-carboxylic acid; polysialic acid; Alpha-Sialoside; 4lkh; 2qwb; N-Acetyl-a-neuraminate; N-Acetyl-a-D-neuraminate; Epitope ID:136794; SCHEMBL79085; N-Acetyl-a-D-neuraminic acid
Indication
Disease Entry ICD 11 Status REF
Discovery agent N.A. Investigative [1]
Cross-matching ID
PubChem CID
444885
ChEBI ID
CHEBI:49026
CAS Number
CAS 21646-00-4
TTD Drug ID
DMCAR7B

Molecule(s) Related to This Drug


Drug Therapeutic Target (DTT)
DTT Name DTT ID UniProt ID MOA REF
E-selectin (SELE) TTAU4D6 LYAM2_HUMAN Inhibitor [1]
Influenza Neuraminidase (Influ NA) TT50QJ3 NRAM_I33A0 Inhibitor [1]
Liver carboxylesterase (CES1) TTMF541 EST1_HUMAN Inhibitor [1]
P-selectin (SELP) TTE5VG0 LYAM3_HUMAN Inhibitor [1]

The Expression Level of Molecule(s) in Normal Tissue of Major ADME-Related Organs

Molecule Molecule Type Gene Name Liver Colon Kidney Small Intestine
Liver carboxylesterase (CES1) DTT CES1 12.04 6.525 5.311 5.909
P-selectin (SELP) DTT SELP 7.304 7.427 7.315 7.849
E-selectin (SELE) DTT SELE 5.194 3.307 3.104 5.907
Molecule Expression Atlas in Normal Tissue of Major ADME-related organs

The Expression Level of Molecule(s) between Disease Section and Healthy Individual Tissue

The Studied Disease Discovery agent
ICD Disease Classification N.A.
Molecule Name Molecule Type Gene Name p-value Fold-Change Z-score
Liver carboxylesterase (CES1) DTT CES1 3.82E-08 1.86 1.9
Molecular Expression Atlas between Disease Section and Healthy Individual Tissue

References

1 The Protein Data Bank. Nucleic Acids Res. 2000 Jan 1;28(1):235-42.